SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3csv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_A_MTXA301_1
(PTERIDINE REDUCTASE)		 3csv AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Ruegeria
sp.
TM1040) 		5 / 12 PRO A 129
LEU A  68
TYR A  67
LEU A 119
LEU A 120
 None
None
EDO  A 346 (-4.3A)
None
None
 1.25A 1e7wA-3csvA:
undetectable		 1e7wA-3csvA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3csv AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Ruegeria
sp.
TM1040) 		5 / 12 VAL A 208
GLY A 207
LEU A  93
PHE A 211
VAL A  46
 None
None
CL  A 335 ( 4.1A)
None
None
 1.23A 1fduC-3csvA:
undetectable		 1fduC-3csvA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 3csv AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Ruegeria
sp.
TM1040) 		4 / 4 LEU A 174
PRO A 136
LEU A 139
ARG A 268
 None
None
None
EDO  A 347 ( 4.3A)
 1.30A 1hrkB-3csvA:
undetectable		 1hrkB-3csvA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 3csv AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Ruegeria
sp.
TM1040) 		3 / 3 ARG A 219
THR A 128
VAL A 183
 None
 1.01A 1hxbA-3csvA:
undetectable		 1hxbA-3csvA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 3csv AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Ruegeria
sp.
TM1040) 		4 / 4 LEU A 174
PRO A 136
LEU A 139
ARG A 268
 None
None
None
EDO  A 347 ( 4.3A)
 1.32A 2hrcB-3csvA:
undetectable		 2hrcB-3csvA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 3csv AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Ruegeria
sp.
TM1040) 		4 / 7 PHE A 189
LEU A 226
LEU A 227
ARG A 258
 None
 0.96A 2jn3A-3csvA:
undetectable		 2jn3A-3csvA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3csv AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Ruegeria
sp.
TM1040) 		5 / 12 LEU A 226
PHE A 189
LEU A 223
HIS A 245
VAL A 252
 None
 0.91A 2pnjB-3csvA:
undetectable		 2pnjB-3csvA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3csv AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Ruegeria
sp.
TM1040) 		4 / 4 LEU A 174
PRO A 136
LEU A 139
ARG A 268
 None
None
None
EDO  A 347 ( 4.3A)
 1.35A 2pnjB-3csvA:
undetectable		 2pnjB-3csvA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 3csv AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Ruegeria
sp.
TM1040) 		3 / 3 ARG A 219
THR A 128
VAL A 183
 None
 0.80A 2q64A-3csvA:
undetectable		 2q64A-3csvA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 3csv AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Ruegeria
sp.
TM1040) 		4 / 6 HIS A 218
GLN A 267
LEU A 178
LEU A 174
 None
 1.12A 3bgdA-3csvA:
undetectable		 3bgdA-3csvA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 3csv AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Ruegeria
sp.
TM1040) 		4 / 7 PHE A  11
LEU A  89
LEU A  37
LEU A  47
 None
 0.88A 3bgdB-3csvA:
undetectable		 3bgdB-3csvA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_1
(GUANINE DEAMINASE)		 3csv AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Ruegeria
sp.
TM1040) 		5 / 12 LEU A 120
LEU A 119
HIS A 186
ALA A 126
SER A 225
 None
None
None
EDO  A 346 ( 4.2A)
None
 0.99A 4aqlA-3csvA:
undetectable		 4aqlA-3csvA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)		 3csv AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Ruegeria
sp.
TM1040) 		3 / 3 ARG A   4
ASP A  57
GLN A  59
 None
None
ZN  A 333 ( 4.0A)
 0.85A 4azsA-3csvA:
3.3		 4azsA-3csvA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		 3csv AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Ruegeria
sp.
TM1040) 		3 / 3 ARG A 232
ARG A 231
ILE A 102
 None
EDO  A 345 ( 4.1A)
None
 0.87A 4b7qC-3csvA:
undetectable		 4b7qC-3csvA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3csv AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Ruegeria
sp.
TM1040) 		5 / 10 LEU A 279
ILE A 289
ILE A 275
GLY A 274
PHE A 291
 None
None
EDO  A 345 ( 4.8A)
None
None
 0.88A 4fakA-3csvA:
undetectable		 4fakA-3csvA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 3csv AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Ruegeria
sp.
TM1040) 		4 / 6 GLU A 167
ARG A 163
ARG A 271
ARG A 144
 None
EDO  A 339 (-3.2A)
EDO  A 342 ( 3.1A)
EDO  A 339 (-3.3A)
 1.17A 5l6eA-3csvA:
undetectable
5l6eB-3csvA:
undetectable		 5l6eA-3csvA:
21.39
5l6eB-3csvA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3csv AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Ruegeria
sp.
TM1040) 		4 / 6 LEU A 216
ASP A 181
ARG A 133
GLN A 127
 None
 1.31A 6g31J-3csvA:
undetectable		 6g31J-3csvA:
12.01