SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3csw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)		 3csw PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 7 PHE A 243
ALA A 220
LEU A 217
VAL A 170
 None
 0.84A 1hk2A-3cswA:
undetectable		 1hk2A-3cswA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 3csw PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 8 TYR A  37
LEU A 199
LEU A 264
GLU A 257
 None
 1.04A 1i7zA-3cswA:
undetectable		 1i7zA-3cswA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)		 3csw PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Thermotoga
maritima) 		3 / 3 THR A 252
PRO A 250
THR A 254
 None
 0.78A 209dC-3cswA:
undetectable		 209dC-3cswA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 3csw PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 8 ILE A 154
ARG A 193
ILE A 147
ASN A 169
VAL A 170
 None
None
None
PLP  A 300 (-3.7A)
None
 1.38A 2nniA-3cswA:
undetectable		 2nniA-3cswA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3csw PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 5 LEU A  34
VAL A 153
LEU A 155
ARG A 145
 None
None
None
CIT  A 302 (-4.3A)
 1.06A 2oiqA-3cswA:
undetectable		 2oiqA-3cswA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 3csw PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 12 SER A 242
PHE A 243
GLY A 112
THR A 111
VAL A 233
 None
 1.15A 2zifA-3cswA:
undetectable		 2zifA-3cswA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 3csw PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 12 SER A 242
PHE A 243
GLY A 112
THR A 111
VAL A 233
 None
 1.11A 2zifB-3cswA:
undetectable		 2zifB-3cswA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 3csw PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 12 GLY A 165
VAL A 115
ALA A 143
GLU A 146
LEU A 155
 None
None
None
CIT  A 302 (-3.4A)
None
 1.06A 3mteB-3cswA:
undetectable		 3mteB-3cswA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 3csw PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 12 GLY A 165
VAL A 115
ALA A 143
GLU A 146
LEU A 155
 None
None
None
CIT  A 302 (-3.4A)
None
 0.94A 3p2kB-3cswA:
undetectable		 3p2kB-3cswA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 3csw PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 7 LEU A 238
VAL A 235
LEU A 109
ASP A 152
 None
 0.73A 3rgfA-3cswA:
undetectable		 3rgfA-3cswA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC2_1
(CYTOCHROME P450 2D6)		 3csw PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 10 LEU A 178
THR A 180
VAL A 207
LEU A 199
PHE A 259
 None
 1.40A 3tbgC-3cswA:
undetectable		 3tbgC-3cswA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_1
(PROTEASE)		 3csw PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 9 LEU A  34
ALA A  77
ASP A  78
LEU A   2
ILE A  86
 None
 1.29A 3wsjA-3cswA:
undetectable		 3wsjA-3cswA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_ADNA2414_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3csw PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 6 GLU A  32
PHE A  69
PHE A  66
TYR A  45
 None
 1.47A 4uciA-3cswA:
undetectable		 4uciA-3cswA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3csw PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 7 GLU A  32
PHE A  69
PHE A  66
TYR A  45
 None
 1.48A 4uciB-3cswA:
undetectable		 4uciB-3cswA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 3csw PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Thermotoga
maritima) 		3 / 3 ARG A  85
PHE A  42
LEU A 104
 None
 0.93A 5x1bC-3cswA:
undetectable		 5x1bC-3cswA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)		 3csw PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 6 GLU A 216
ARG A 210
VAL A 170
PRO A 181
 None
 1.46A 6fgdA-3cswA:
undetectable		 6fgdA-3cswA:
22.76