SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ct4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_2
(HMG-COA REDUCTASE)		 3ct4 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Lactococcus
lactis) 		5 / 11 GLU A 270
SER A 194
LEU A 193
ALA A 192
LEU A 191
 None
 1.47A 1hwkB-3ct4A:
undetectable		 1hwkB-3ct4A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_A_ADNA1245_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3ct4 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Lactococcus
lactis) 		5 / 9 MET A 121
GLY A 110
GLU A 116
MET A 117
SER A  82
 None
 1.40A 1pk7A-3ct4A:
3.6		 1pk7A-3ct4A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_A_RABA645_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3ct4 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Lactococcus
lactis) 		5 / 10 MET A 121
GLY A 110
GLU A 116
MET A 117
SER A  82
 None
 1.39A 1pw7A-3ct4A:
3.8		 1pw7A-3ct4A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3ct4 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Lactococcus
lactis) 		3 / 3 GLU A 246
GLU A 285
LEU A 308
 None
 0.72A 1v8bA-3ct4A:
undetectable		 1v8bA-3ct4A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 3ct4 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Lactococcus
lactis) 		5 / 12 GLY A 190
ALA A 139
ILE A 138
VAL A 260
ALA A 153
 None
 1.42A 1vq1A-3ct4A:
undetectable		 1vq1A-3ct4A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3ct4 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Lactococcus
lactis) 		5 / 9 LEU A 313
LEU A 319
PHE A 291
LEU A 157
ILE A 311
 None
 1.03A 2f78B-3ct4A:
undetectable		 2f78B-3ct4A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3ct4 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Lactococcus
lactis) 		5 / 9 LEU A 313
LEU A 319
PHE A 291
LEU A 157
ILE A 311
 None
 0.98A 2f7aB-3ct4A:
undetectable		 2f7aB-3ct4A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3ct4 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Lactococcus
lactis) 		5 / 10 LEU A 313
LEU A 319
PHE A 291
LEU A 157
ILE A 311
 None
 1.05A 2f8dA-3ct4A:
undetectable		 2f8dA-3ct4A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3ct4 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Lactococcus
lactis) 		5 / 10 LEU A 313
LEU A 319
PHE A 291
LEU A 157
ILE A 311
 None
 1.03A 2f8dB-3ct4A:
undetectable		 2f8dB-3ct4A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3ct4 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Lactococcus
lactis) 		5 / 12 LEU A 193
GLY A 305
GLY A 262
LEU A 191
LEU A 236
 None
 1.11A 3cjtG-3ct4A:
undetectable		 3cjtG-3ct4A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_K_SAMK302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3ct4 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Lactococcus
lactis) 		5 / 12 LEU A 193
GLY A 305
SER A 300
LEU A 191
LEU A 236
 None
 1.31A 3cjtK-3ct4A:
undetectable		 3cjtK-3ct4A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_A_GW6A1_2
(GLUCOCORTICOID
RECEPTOR)		 3ct4 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Lactococcus
lactis) 		5 / 9 LEU A 306
LEU A 191
MET A 303
ALA A 265
TYR A 297
 None
 1.50A 3cldA-3ct4A:
0.0		 3cldA-3ct4A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_A_LURA201_1
(TRANSTHYRETIN)		 3ct4 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Lactococcus
lactis) 		4 / 4 LYS A 176
LEU A 102
ALA A 179
VAL A 183
 None
 1.35A 4ik6A-3ct4A:
undetectable		 4ik6A-3ct4A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3ct4 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Lactococcus
lactis) 		5 / 12 LEU A 281
ASP A 277
MET A 275
PHE A 274
ILE A 258
 None
 0.95A 4pghD-3ct4A:
undetectable		 4pghD-3ct4A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 3ct4 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Lactococcus
lactis) 		5 / 9 ASN A 107
ILE A 133
GLY A 151
THR A 188
VAL A 183
 None
 1.21A 4r20B-3ct4A:
undetectable		 4r20B-3ct4A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 3ct4 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Lactococcus
lactis) 		3 / 3 LYS A 187
ASP A 137
ILE A 258
 None
 0.59A 5kc4E-3ct4A:
undetectable		 5kc4E-3ct4A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 3ct4 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Lactococcus
lactis) 		5 / 10 PRO A  83
LEU A 103
ALA A  91
ILE A  92
ILE A  37
 None
 1.05A 5mvmD-3ct4A:
undetectable
5mvmE-3ct4A:
undetectable		 5mvmD-3ct4A:
15.77
5mvmE-3ct4A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 3ct4 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Lactococcus
lactis) 		5 / 12 ALA A  99
GLY A 100
GLN A 131
LEU A 103
GLU A 116
 None
 1.06A 5nwuA-3ct4A:
undetectable		 5nwuA-3ct4A:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)		 3ct4 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Lactococcus
lactis) 		5 / 12 ALA A  95
LEU A  50
VAL A  75
CYH A  76
PHE A 115
 None
 1.40A 5vlmB-3ct4A:
undetectable		 5vlmB-3ct4A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_0
(REGULATORY PROTEIN
TETR)		 3ct4 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Lactococcus
lactis) 		5 / 12 ALA A  95
LEU A  50
VAL A  75
CYH A  76
PHE A 115
 None
 1.37A 5vlmD-3ct4A:
1.1		 5vlmD-3ct4A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 3ct4 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Lactococcus
lactis) 		5 / 12 ALA A  95
LEU A  50
VAL A  75
CYH A  76
PHE A 115
 None
 1.43A 5vlmE-3ct4A:
undetectable		 5vlmE-3ct4A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_0
(CARNOSINE
N-METHYLTRANSFERASE)		 3ct4 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Lactococcus
lactis) 		5 / 12 GLY A 262
GLY A 305
ASN A 296
SER A 300
MET A 303
 None
 1.31A 5yf0A-3ct4A:
undetectable		 5yf0A-3ct4A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3ct4 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Lactococcus
lactis) 		5 / 12 TYR A 225
ILE A 189
ILE A 138
ASP A 137
ARG A 150
 None
 1.39A 6ca3A-3ct4A:
undetectable		 6ca3A-3ct4A:
12.46