SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ctp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2002_1
(SERUM ALBUMIN)		 3ctp PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Alkaliphilus
metalliredigens) 		4 / 9 ILE A 229
ALA A 243
VAL A 246
LYS A 251
 None
 1.04A 2vufB-3ctpA:
undetectable		 2vufB-3ctpA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 3ctp PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Alkaliphilus
metalliredigens) 		4 / 5 LEU A 297
ILE A  82
ILE A 298
GLY A 119
 None
 0.72A 3bufA-3ctpA:
undetectable		 3bufA-3ctpA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3ctp PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Alkaliphilus
metalliredigens) 		3 / 3 TYR A 157
ASP A 155
ASP A 310
 None
 0.86A 3ou7B-3ctpA:
2.3		 3ou7B-3ctpA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 3ctp PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Alkaliphilus
metalliredigens) 		5 / 12 ILE A 178
LEU A 279
ILE A 257
LEU A 250
ILE A 235
 None
 1.01A 3tq9A-3ctpA:
undetectable		 3tq9A-3ctpA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGA_A_ACTA1131_0
(LYSOZYME C)		 3ctp PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Alkaliphilus
metalliredigens) 		3 / 3 ASN A 239
ASP A 213
ASN A  72
 XLF  A 401 (-3.8A)
XLF  A 401 ( 4.3A)
XLF  A 401 (-3.0A)
 0.75A 4agaA-3ctpA:
undetectable		 4agaA-3ctpA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 3ctp PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Alkaliphilus
metalliredigens) 		4 / 7 THR A 280
GLY A 265
VAL A 237
GLY A 234
 None
 0.87A 4forA-3ctpA:
undetectable		 4forA-3ctpA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3ctp PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Alkaliphilus
metalliredigens) 		3 / 3 ASP A 240
ARG A 124
THR A 281
 None
XLF  A 401 (-4.0A)
None
 0.80A 4i13A-3ctpA:
undetectable		 4i13A-3ctpA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 3ctp PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Alkaliphilus
metalliredigens) 		3 / 3 SER A 125
TYR A 131
PRO A  68
 None
 0.96A 4k8cA-3ctpA:
3.0		 4k8cA-3ctpA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3ctp PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Alkaliphilus
metalliredigens) 		3 / 3 SER A 125
TYR A 131
PRO A  68
 None
 0.97A 4kahB-3ctpA:
2.3		 4kahB-3ctpA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3ctp PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Alkaliphilus
metalliredigens) 		3 / 3 SER A 125
TYR A 131
PRO A  68
 None
 0.97A 4kanA-3ctpA:
2.6		 4kanA-3ctpA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3ctp PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Alkaliphilus
metalliredigens) 		3 / 3 SER A 125
TYR A 131
PRO A  68
 None
 0.96A 4kanB-3ctpA:
2.3		 4kanB-3ctpA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3ctp PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Alkaliphilus
metalliredigens) 		3 / 3 SER A 125
TYR A 131
PRO A  68
 None
 0.97A 4kbeB-3ctpA:
3.0		 4kbeB-3ctpA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3ctp PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Alkaliphilus
metalliredigens) 		3 / 3 SER A 125
TYR A 131
PRO A  68
 None
 0.96A 4lbgA-3ctpA:
2.2		 4lbgA-3ctpA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3ctp PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Alkaliphilus
metalliredigens) 		3 / 3 SER A 125
TYR A 131
PRO A  68
 None
 0.97A 4lbgB-3ctpA:
2.4		 4lbgB-3ctpA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3ctp PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Alkaliphilus
metalliredigens) 		3 / 3 ASP A 240
ARG A 124
THR A 281
 None
XLF  A 401 (-4.0A)
None
 0.80A 4p3rA-3ctpA:
undetectable		 4p3rA-3ctpA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 3ctp PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Alkaliphilus
metalliredigens) 		4 / 6 ARG A 124
ARG A 190
ASP A 213
ASP A 267
 XLF  A 401 (-4.0A)
XLF  A 401 (-2.8A)
XLF  A 401 ( 4.3A)
XLF  A 401 (-2.8A)
 1.08A 4xqeA-3ctpA:
3.4		 4xqeA-3ctpA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 3ctp PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Alkaliphilus
metalliredigens) 		4 / 6 ARG A 124
ARG A 190
ASP A 213
ASP A 267
 XLF  A 401 (-4.0A)
XLF  A 401 (-2.8A)
XLF  A 401 ( 4.3A)
XLF  A 401 (-2.8A)
 1.09A 4xqeB-3ctpA:
2.2		 4xqeB-3ctpA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 3ctp PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Alkaliphilus
metalliredigens) 		4 / 8 ARG A 124
ARG A 190
ASP A 213
ASP A 267
 XLF  A 401 (-4.0A)
XLF  A 401 (-2.8A)
XLF  A 401 ( 4.3A)
XLF  A 401 (-2.8A)
 1.10A 4xqgA-3ctpA:
undetectable		 4xqgA-3ctpA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 3ctp PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Alkaliphilus
metalliredigens) 		4 / 8 ARG A 124
ARG A 190
ASP A 213
ASP A 267
 XLF  A 401 (-4.0A)
XLF  A 401 (-2.8A)
XLF  A 401 ( 4.3A)
XLF  A 401 (-2.8A)
 1.11A 4xqgB-3ctpA:
3.0		 4xqgB-3ctpA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 3ctp PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Alkaliphilus
metalliredigens) 		4 / 8 LEU A 112
LEU A  95
THR A  92
TYR A  91
 None
 1.13A 5hbsA-3ctpA:
undetectable		 5hbsA-3ctpA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 3ctp PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Alkaliphilus
metalliredigens) 		6 / 12 ASP A 155
ILE A 312
VAL A 315
ASP A 310
LEU A 189
ALA A 186
 None
None
None
None
None
XLF  A 401 ( 3.9A)
 1.43A 6bq4A-3ctpA:
4.1		 6bq4A-3ctpA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 3ctp PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Alkaliphilus
metalliredigens) 		6 / 12 ASP A 155
ILE A 312
VAL A 315
ASP A 310
LEU A 189
ALA A 186
 None
None
None
None
None
XLF  A 401 ( 3.9A)
 1.43A 6bq4B-3ctpA:
3.1		 6bq4B-3ctpA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 3ctp PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Alkaliphilus
metalliredigens) 		4 / 9 PHE A 194
HIS A 166
LEU A 189
SER A 153
 None
 0.87A 6c2mD-3ctpA:
undetectable		 6c2mD-3ctpA:
15.75