SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ctz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		3 / 3 ARG A 429
THR A 425
VAL A 427
 None
 0.93A 1hxbA-3ctzA:
undetectable		 1hxbA-3ctzA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 7 SER A 416
ALA A 418
TYR A 420
ALA A 366
 None
 1.02A 1k5qA-3ctzA:
undetectable
1k5qB-3ctzA:
undetectable		 1k5qA-3ctzA:
16.75
1k5qB-3ctzA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 12 LEU A 408
LEU A 406
ALA A 363
ALA A 366
ALA A 362
 None
 0.99A 1rbpA-3ctzA:
undetectable		 1rbpA-3ctzA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_L_URFL2071_1
(URIDINE
PHOSPHORYLASE)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 7 GLY A 492
GLN A 419
ILE A 519
VAL A 491
 None
 1.08A 1rxcL-3ctzA:
undetectable		 1rxcL-3ctzA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 5 TRP A 207
ILE A 315
LEU A 495
ALA A 206
 None
 1.17A 1xvaA-3ctzA:
undetectable
1xvaB-3ctzA:
undetectable		 1xvaA-3ctzA:
20.59
1xvaB-3ctzA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 7 SER A 479
LEU A 476
GLY A 450
ILE A 567
 None
 0.99A 2bdmA-3ctzA:
undetectable		 2bdmA-3ctzA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 11 LEU A 235
ILE A 263
VAL A 247
LEU A 211
SER A 224
 None
 1.36A 2bxeA-3ctzA:
undetectable		 2bxeA-3ctzA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2001_1
(SERUM ALBUMIN)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 12 ILE A 414
PHE A 381
TYR A 420
VAL A 427
LEU A 341
 None
P6G  A 628 ( 4.0A)
None
None
None
 1.27A 2bxeB-3ctzA:
undetectable		 2bxeB-3ctzA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 6 ILE A  64
TYR A 128
MET A 132
LEU A 136
 None
 0.66A 2einN-3ctzA:
undetectable
2einW-3ctzA:
undetectable		 2einN-3ctzA:
21.45
2einW-3ctzA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		3 / 3 ARG A 429
THR A 425
VAL A 427
 None
 0.92A 2q64A-3ctzA:
undetectable		 2q64A-3ctzA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		3 / 3 ARG A 429
THR A 425
VAL A 427
 None
 0.89A 2qakA-3ctzA:
undetectable		 2qakA-3ctzA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		3 / 3 ASP A 238
THR A 156
GLU A 160
 None
 0.75A 2zifB-3ctzA:
undetectable		 2zifB-3ctzA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 12 VAL A 458
SER A 556
LEU A 557
THR A 558
ASN A 550
 None
 1.00A 3a35A-3ctzA:
undetectable		 3a35A-3ctzA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 12 VAL A 458
SER A 556
LEU A 557
THR A 558
ASN A 550
 None
 0.95A 3a35B-3ctzA:
undetectable		 3a35B-3ctzA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3B_A_RBFA191_1
(LUMAZINE PROTEIN)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 12 VAL A 458
SER A 556
LEU A 557
THR A 558
ASN A 550
 None
 0.90A 3a3bA-3ctzA:
undetectable		 3a3bA-3ctzA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 6 ILE A  64
TYR A 128
MET A 132
LEU A 136
 None
 0.60A 3ag1N-3ctzA:
undetectable
3ag1W-3ctzA:
undetectable		 3ag1N-3ctzA:
21.45
3ag1W-3ctzA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 10 ASP A 337
ALA A 418
VAL A 565
LEU A 344
PHE A 345
 None
 1.34A 3ay0A-3ctzA:
undetectable		 3ay0A-3ctzA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 6 LEU A 235
VAL A 265
LEU A 166
ASP A 240
 None
 0.87A 3cs9D-3ctzA:
undetectable		 3cs9D-3ctzA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 7 LYS A 319
GLU A 204
ASP A 203
SER A 291
 None
 1.41A 3dzgA-3ctzA:
undetectable		 3dzgA-3ctzA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 4 LEU A  13
MET A  86
ILE A 124
ASP A  47
 None
 1.30A 3hecA-3ctzA:
undetectable		 3hecA-3ctzA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 12 ILE A 263
PHE A 209
LEU A 211
ILE A 237
SER A 224
 None
 1.13A 3k2hB-3ctzA:
undetectable		 3k2hB-3ctzA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 12 SER A 479
LEU A 448
PHE A 444
ILE A 572
LEU A 577
 None
 1.25A 3ko0G-3ctzA:
undetectable
3ko0H-3ctzA:
undetectable
3ko0I-3ctzA:
undetectable
3ko0J-3ctzA:
undetectable		 3ko0G-3ctzA:
9.50
3ko0H-3ctzA:
9.50
3ko0I-3ctzA:
9.50
3ko0J-3ctzA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 11 SER A 479
LEU A 577
LEU A 448
PHE A 444
ILE A 572
 None
 1.24A 3ko0A-3ctzA:
undetectable
3ko0B-3ctzA:
undetectable
3ko0I-3ctzA:
undetectable
3ko0J-3ctzA:
undetectable		 3ko0A-3ctzA:
9.50
3ko0B-3ctzA:
9.50
3ko0I-3ctzA:
9.50
3ko0J-3ctzA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 12 SER A 479
LEU A 577
LEU A 448
PHE A 444
ILE A 572
 None
 1.23A 3ko0M-3ctzA:
undetectable
3ko0N-3ctzA:
undetectable
3ko0O-3ctzA:
undetectable
3ko0P-3ctzA:
undetectable		 3ko0M-3ctzA:
9.50
3ko0N-3ctzA:
9.50
3ko0O-3ctzA:
9.50
3ko0P-3ctzA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_A_URFA254_1
(URIDINE
PHOSPHORYLASE)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 6 GLY A 492
GLN A 419
ILE A 519
VAL A 491
 None
 1.09A 3kvvA-3ctzA:
undetectable		 3kvvA-3ctzA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_B_URFB254_1
(URIDINE
PHOSPHORYLASE)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 6 GLY A 492
GLN A 419
ILE A 519
VAL A 491
 None
 1.07A 3kvvB-3ctzA:
undetectable		 3kvvB-3ctzA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_C_URFC254_1
(URIDINE
PHOSPHORYLASE)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 6 GLY A 492
GLN A 419
ILE A 519
VAL A 491
 None
 1.05A 3kvvC-3ctzA:
undetectable		 3kvvC-3ctzA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_D_URFD254_1
(URIDINE
PHOSPHORYLASE)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 6 GLY A 492
GLN A 419
ILE A 519
VAL A 491
 None
 1.13A 3kvvD-3ctzA:
undetectable		 3kvvD-3ctzA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_E_URFE254_1
(URIDINE
PHOSPHORYLASE)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 6 GLY A 492
GLN A 419
ILE A 519
VAL A 491
 None
 1.11A 3kvvE-3ctzA:
undetectable		 3kvvE-3ctzA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 6 GLY A 492
GLN A 419
ILE A 519
VAL A 491
 None
 1.10A 3kvvF-3ctzA:
undetectable		 3kvvF-3ctzA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 12 VAL A 298
SER A 299
SER A 291
LEU A 202
HIS A  38
 None
 1.25A 3m7rA-3ctzA:
undetectable		 3m7rA-3ctzA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 8 PRO A 121
TYR A 296
PRO A 125
GLN A  39
 None
 1.09A 3oyaA-3ctzA:
2.8		 3oyaA-3ctzA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P73_A_ACTA275_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		3 / 3 ILE A 233
VAL A 182
ARG A 186
 None
 0.75A 3p73A-3ctzA:
undetectable		 3p73A-3ctzA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 12 GLN A  81
PHE A  56
GLY A  58
GLY A  55
ALA A  51
 None
 0.87A 3sudB-3ctzA:
undetectable		 3sudB-3ctzA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 8 VAL A 247
LEU A 251
LEU A 253
ILE A 237
 None
 0.74A 3u5kA-3ctzA:
undetectable		 3u5kA-3ctzA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 7 VAL A 247
LEU A 251
LEU A 253
ILE A 237
 None
 0.80A 3u5kB-3ctzA:
undetectable		 3u5kB-3ctzA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 8 VAL A 247
LEU A 251
LEU A 253
ILE A 237
 None
 0.71A 3u5kC-3ctzA:
undetectable		 3u5kC-3ctzA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		3 / 3 ASP A 579
LYS A 580
ASP A 583
 None
 0.82A 4a7tA-3ctzA:
undetectable		 4a7tA-3ctzA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 5 VAL A 247
LEU A 251
LEU A 253
ILE A 237
 None
 0.73A 4a9jA-3ctzA:
undetectable		 4a9jA-3ctzA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_B_TYLB1187_1
(BROMODOMAIN
CONTAINING 2)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 5 VAL A 247
LEU A 251
LEU A 253
ILE A 237
 None
 0.78A 4a9jB-3ctzA:
undetectable		 4a9jB-3ctzA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 5 VAL A 247
LEU A 251
LEU A 253
ILE A 237
 None
 0.78A 4a9jC-3ctzA:
undetectable		 4a9jC-3ctzA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_F_URFF1301_1
(URIDINE
PHOSPHORYLASE)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 6 GLY A 492
GLN A 419
ILE A 519
VAL A 491
 None
 1.16A 4e1vF-3ctzA:
undetectable		 4e1vF-3ctzA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		3 / 3 PHE A 494
VAL A 539
ILE A 519
 None
 0.62A 4emaA-3ctzA:
0.0		 4emaA-3ctzA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 10 ALA A  16
LEU A  13
VAL A  53
ILE A  64
ALA A  63
 None
 1.02A 4j14A-3ctzA:
undetectable		 4j14A-3ctzA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		3 / 3 GLY A 525
GLU A 523
THR A 487
 None
MN  A 624 ( 2.5A)
None
 0.47A 4kouA-3ctzA:
undetectable		 4kouA-3ctzA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		3 / 3 TYR A 296
ARG A 307
SER A 299
 None
 1.08A 4lf7I-3ctzA:
undetectable
4lf7J-3ctzA:
undetectable		 4lf7I-3ctzA:
11.41
4lf7J-3ctzA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		3 / 3 TYR A 296
ARG A 307
SER A 299
 None
 1.08A 4lf8I-3ctzA:
undetectable
4lf8J-3ctzA:
undetectable		 4lf8I-3ctzA:
11.41
4lf8J-3ctzA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 6 ASP A 120
VAL A 151
ASP A 152
ALA A  37
 None
 1.14A 4nedA-3ctzA:
undetectable		 4nedA-3ctzA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 12 LEU A   9
ALA A  63
ILE A  65
ALA A  70
ILE A  32
 None
 0.64A 4o2bD-3ctzA:
undetectable		 4o2bD-3ctzA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		3 / 3 ARG A 473
ASP A 482
TRP A 477
 None
 1.18A 4xdqA-3ctzA:
undetectable		 4xdqA-3ctzA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		3 / 3 PHE A 345
ILE A 414
ASP A 364
 None
 0.65A 5cswA-3ctzA:
undetectable		 5cswA-3ctzA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 8 ILE A 124
TYR A 128
GLY A 118
LEU A 107
 None
 0.71A 5esfA-3ctzA:
undetectable		 5esfA-3ctzA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 12 LEU A   9
ALA A  63
ILE A  65
ALA A  70
ILE A  32
 None
 0.67A 5eypB-3ctzA:
undetectable		 5eypB-3ctzA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_B_RBFB201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 12 ASP A 337
GLY A 417
VAL A 377
TYR A 420
ASN A 219
 None
 1.39A 5kbwB-3ctzA:
undetectable		 5kbwB-3ctzA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 7 ILE A  64
TYR A 128
MET A 132
LEU A 136
 None
 0.45A 5xdqA-3ctzA:
undetectable
5xdqJ-3ctzA:
undetectable		 5xdqA-3ctzA:
21.45
5xdqJ-3ctzA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 7 ILE A  64
TYR A 128
MET A 132
LEU A 136
 None
 0.42A 5xdqN-3ctzA:
1.9
5xdqW-3ctzA:
undetectable		 5xdqN-3ctzA:
21.45
5xdqW-3ctzA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 12 LEU A   9
ALA A  63
ILE A  65
ALA A  70
ILE A  32
 None
 0.73A 5xiwB-3ctzA:
undetectable		 5xiwB-3ctzA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 12 LEU A   9
ALA A  63
ILE A  65
ALA A  70
ILE A  32
 None
 0.66A 5xiwD-3ctzA:
undetectable		 5xiwD-3ctzA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 8 VAL A 247
LEU A 251
LEU A 253
ILE A 237
 None
 0.76A 5y1yA-3ctzA:
undetectable		 5y1yA-3ctzA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		3 / 3 ILE A 154
ASN A 149
CYH A  46
 None
 0.90A 6bp4A-3ctzA:
undetectable		 6bp4A-3ctzA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 12 HIS A 485
VAL A 565
ARG A 535
VAL A 427
ASP A 415
 P6G  A 628 (-3.5A)
None
P6G  A 628 ( 4.3A)
None
MN  A 625 (-1.9A)
 1.32A 6bxlB-3ctzA:
undetectable		 6bxlB-3ctzA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 9 PHE A 444
VAL A 447
HIS A 451
ASP A 482
 None
 0.96A 6c2mD-3ctzA:
undetectable		 6c2mD-3ctzA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		3 / 3 THR A  74
ALA A  82
LYS A  84
 None
 0.67A 6fgcA-3ctzA:
undetectable		 6fgcA-3ctzA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		3 / 3 THR A  74
ALA A  82
LYS A  84
 None
 0.68A 6fgdA-3ctzA:
undetectable		 6fgdA-3ctzA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 7 ILE A  64
TYR A 128
MET A 132
LEU A 136
 None
 0.55A 6nmpA-3ctzA:
undetectable
6nmpJ-3ctzA:
undetectable		 6nmpA-3ctzA:
21.45
6nmpJ-3ctzA:
7.66