SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cu2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3cu2 RIBULOSE-5-PHOSPHATE
3-EPIMERASE
(Histophilus
somni) 		5 / 11 CYH A 131
LEU A 154
THR A 155
THR A  96
ILE A 151
 None
 1.25A 1pkvA-3cu2A:
undetectable
1pkvB-3cu2A:
undetectable		 1pkvA-3cu2A:
17.54
1pkvB-3cu2A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 3cu2 RIBULOSE-5-PHOSPHATE
3-EPIMERASE
(Histophilus
somni) 		3 / 3 TRP A 212
LEU A 213
LYS A 204
 None
 0.88A 1yajK-3cu2A:
2.0		 1yajK-3cu2A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_1
(PROTEASE)		 3cu2 RIBULOSE-5-PHOSPHATE
3-EPIMERASE
(Histophilus
somni) 		6 / 12 GLY A  91
ALA A  92
ASP A  72
GLY A  61
ILE A  60
VAL A  83
 None
 1.44A 2ieoA-3cu2A:
undetectable		 2ieoA-3cu2A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 3cu2 RIBULOSE-5-PHOSPHATE
3-EPIMERASE
(Histophilus
somni) 		4 / 8 ASP A  45
ASP A 192
LEU A 154
LEU A  54
 NI  A 238 (-2.5A)
NI  A 238 (-2.6A)
None
None
 1.08A 2q0iA-3cu2A:
undetectable		 2q0iA-3cu2A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_2
(PROTEASE)		 3cu2 RIBULOSE-5-PHOSPHATE
3-EPIMERASE
(Histophilus
somni) 		6 / 12 GLY A  91
ALA A  92
ASP A  72
GLY A  61
ILE A  60
VAL A  83
 None
 1.47A 2q5kB-3cu2A:
undetectable		 2q5kB-3cu2A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)		 3cu2 RIBULOSE-5-PHOSPHATE
3-EPIMERASE
(Histophilus
somni) 		5 / 12 LEU A 153
VAL A 150
ARG A 184
HIS A  43
MET A 195
 None
None
None
NI  A 238 (-3.3A)
None
 1.36A 4olmA-3cu2A:
undetectable		 4olmA-3cu2A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 3cu2 RIBULOSE-5-PHOSPHATE
3-EPIMERASE
(Histophilus
somni) 		4 / 5 LEU A  42
VAL A  57
VAL A  87
ARG A 159
 None
 1.06A 4r7iA-3cu2A:
undetectable		 4r7iA-3cu2A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 3cu2 RIBULOSE-5-PHOSPHATE
3-EPIMERASE
(Histophilus
somni) 		5 / 12 ILE A 148
GLY A 129
THR A  96
LEU A 145
VAL A 176
 None
 1.22A 5hw4A-3cu2A:
undetectable		 5hw4A-3cu2A:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 3cu2 RIBULOSE-5-PHOSPHATE
3-EPIMERASE
(Histophilus
somni) 		5 / 12 ILE A 148
GLY A 129
THR A  96
LEU A 145
VAL A 176
 None
 1.22A 5hw4C-3cu2A:
undetectable		 5hw4C-3cu2A:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 3cu2 RIBULOSE-5-PHOSPHATE
3-EPIMERASE
(Histophilus
somni) 		5 / 12 VAL A  87
ILE A  19
TRP A  24
VAL A  73
PHE A  44
 None
 1.26A 6ap6B-3cu2A:
2.4		 6ap6B-3cu2A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 3cu2 RIBULOSE-5-PHOSPHATE
3-EPIMERASE
(Histophilus
somni) 		3 / 3 ASP A 192
SER A 217
SER A  21
 NI  A 238 (-2.6A)
None
None
 0.80A 6mxtA-3cu2A:
undetectable		 6mxtA-3cu2A:
19.57