SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cuq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3cuq VACUOLAR-SORTING
PROTEIN SNF8
(Homo
sapiens) 		4 / 8 SER A  88
VAL A  93
TYR A  98
PRO A  79
 None
 1.02A 1fduB-3cuqA:
undetectable		 1fduB-3cuqA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 3cuq VACUOLAR-SORTING
PROTEIN SNF8
VACUOLAR
PROTEIN-SORTING-ASSO
CIATED PROTEIN 36
(Homo
sapiens;
Homo
sapiens) 		5 / 12 LEU A 154
LEU B 272
VAL B 273
ILE B 252
LEU B 294
 None
 1.04A 1s19A-3cuqA:
undetectable		 1s19A-3cuqA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 3cuq VACUOLAR-SORTING
PROTEIN SNF8
VACUOLAR
PROTEIN-SORTING-ASSO
CIATED PROTEIN 36
(Homo
sapiens;
Homo
sapiens) 		5 / 12 LEU A 154
VAL B 273
ILE B 252
LEU B 294
LEU B 301
 None
 0.98A 1s19A-3cuqA:
undetectable		 1s19A-3cuqA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 3cuq VACUOLAR-SORTING
PROTEIN SNF8
(Homo
sapiens) 		4 / 7 SER A 171
ILE A 145
ILE A 148
LYS A 149
 None
 0.97A 1sbrB-3cuqA:
undetectable		 1sbrB-3cuqA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3cuq VACUOLAR
PROTEIN-SORTING-ASSO
CIATED PROTEIN 25
(Homo
sapiens) 		4 / 8 PHE C 175
LEU C 149
LEU C 150
ALA C 162
 None
 0.64A 2vcvP-3cuqC:
undetectable		 2vcvP-3cuqC:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 3cuq VACUOLAR-SORTING
PROTEIN SNF8
(Homo
sapiens) 		5 / 12 ILE A 105
LEU A 151
ILE A 148
ALA A 147
LEU A 124
 None
 1.06A 3a50A-3cuqA:
undetectable		 3a50A-3cuqA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 3cuq VACUOLAR-SORTING
PROTEIN SNF8
(Homo
sapiens) 		5 / 12 ILE A 105
LEU A 151
ILE A 148
VAL A 128
LEU A 124
 None
 1.16A 3a51D-3cuqA:
undetectable		 3a51D-3cuqA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)		 3cuq VACUOLAR
PROTEIN-SORTING-ASSO
CIATED PROTEIN 25
(Homo
sapiens) 		3 / 3 CYH C  41
HIS C  44
PHE C   5
 None
 1.14A 3cr4X-3cuqC:
undetectable		 3cr4X-3cuqC:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)		 3cuq VACUOLAR
PROTEIN-SORTING-ASSO
CIATED PROTEIN 25
(Homo
sapiens) 		4 / 6 LEU C  36
SER C  39
LEU C  43
LEU C  59
 None
 1.01A 3f33A-3cuqC:
undetectable		 3f33A-3cuqC:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 3cuq VACUOLAR
PROTEIN-SORTING-ASSO
CIATED PROTEIN 36
VACUOLAR-SORTING
PROTEIN SNF8
(Homo
sapiens) 		4 / 7 LEU B 249
LEU B 352
LEU B 257
LEU A 109
 None
 0.91A 3g8iA-3cuqB:
undetectable		 3g8iA-3cuqB:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3cuq VACUOLAR
PROTEIN-SORTING-ASSO
CIATED PROTEIN 36
(Homo
sapiens) 		4 / 7 VAL B 273
VAL B 269
LEU B 266
SER B 265
 None
 0.83A 3hs6B-3cuqB:
undetectable		 3hs6B-3cuqB:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 3cuq VACUOLAR
PROTEIN-SORTING-ASSO
CIATED PROTEIN 36
VACUOLAR
PROTEIN-SORTING-ASSO
CIATED PROTEIN 25
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ASP C  24
ASN C  22
SER B 339
 None
 0.89A 3lslA-3cuqC:
undetectable
3lslD-3cuqC:
undetectable		 3lslA-3cuqC:
20.83
3lslD-3cuqC:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3cuq VACUOLAR-SORTING
PROTEIN SNF8
VACUOLAR
PROTEIN-SORTING-ASSO
CIATED PROTEIN 36
(Homo
sapiens;
Homo
sapiens) 		5 / 12 GLY A  94
GLY A  85
LEU A 100
ASP A  95
PRO B 284
 None
 1.14A 4blvA-3cuqA:
undetectable		 4blvA-3cuqA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 3cuq VACUOLAR
PROTEIN-SORTING-ASSO
CIATED PROTEIN 25
(Homo
sapiens) 		3 / 3 ASN C 121
LEU C 130
PHE C 176
 None
 0.66A 4dajB-3cuqC:
undetectable		 4dajB-3cuqC:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 3cuq VACUOLAR
PROTEIN-SORTING-ASSO
CIATED PROTEIN 25
(Homo
sapiens) 		4 / 6 PHE C 175
ALA C 162
GLY C 108
LEU C 153
 None
 0.86A 4dubB-3cuqC:
undetectable		 4dubB-3cuqC:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 3cuq VACUOLAR
PROTEIN-SORTING-ASSO
CIATED PROTEIN 25
(Homo
sapiens) 		4 / 8 ASN C 121
GLN C 120
GLY C 119
SER C 118
 None
 0.96A 4f93B-3cuqC:
3.7		 4f93B-3cuqC:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_1
(ADENOSINE KINASE)		 3cuq VACUOLAR-SORTING
PROTEIN SNF8
(Homo
sapiens) 		6 / 12 CYH A 108
LEU A 100
GLY A 159
ALA A 147
LEU A 144
GLY A 155
 None
 1.45A 4n09C-3cuqA:
undetectable		 4n09C-3cuqA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3cuq VACUOLAR
PROTEIN-SORTING-ASSO
CIATED PROTEIN 36
VACUOLAR-SORTING
PROTEIN SNF8
(Homo
sapiens) 		4 / 5 TYR A  97
ARG A 146
ASP A  70
VAL B 192
 None
 1.28A 4nkvB-3cuqA:
undetectable		 4nkvB-3cuqA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 3cuq VACUOLAR
PROTEIN-SORTING-ASSO
CIATED PROTEIN 36
(Homo
sapiens) 		3 / 3 MET B 264
GLU B 268
LEU B 272
 None
 0.51A 4v2oB-3cuqB:
undetectable		 4v2oB-3cuqB:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 3cuq VACUOLAR
PROTEIN-SORTING-ASSO
CIATED PROTEIN 36
(Homo
sapiens) 		4 / 5 PHE B 306
ARG B 304
ILE B 263
GLU B 320
 None
 1.44A 4zzcC-3cuqB:
0.0
4zzcD-3cuqB:
0.0		 4zzcC-3cuqB:
21.12
4zzcD-3cuqB:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE401_0
(PROTON-GATED ION
CHANNEL)		 3cuq VACUOLAR
PROTEIN-SORTING-ASSO
CIATED PROTEIN 36
(Homo
sapiens) 		4 / 5 ARG B 304
ILE B 263
GLU B 320
PHE B 306
 None
 1.45A 4zzcA-3cuqB:
0.0
4zzcE-3cuqB:
0.0		 4zzcA-3cuqB:
21.12
4zzcE-3cuqB:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 3cuq VACUOLAR-SORTING
PROTEIN SNF8
VACUOLAR
PROTEIN-SORTING-ASSO
CIATED PROTEIN 36
(Homo
sapiens;
Homo
sapiens) 		5 / 10 GLY A 155
GLY B 309
SER B 308
LEU B 351
GLU B 355
 None
 1.18A 5hwkA-3cuqA:
undetectable		 5hwkA-3cuqA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 3cuq VACUOLAR-SORTING
PROTEIN SNF8
VACUOLAR
PROTEIN-SORTING-ASSO
CIATED PROTEIN 36
(Homo
sapiens;
Homo
sapiens) 		5 / 10 GLY A 155
GLY B 309
SER B 308
LEU B 351
GLU B 355
 None
 1.18A 5hwkB-3cuqA:
undetectable		 5hwkB-3cuqA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 3cuq VACUOLAR
PROTEIN-SORTING-ASSO
CIATED PROTEIN 36
(Homo
sapiens) 		4 / 6 GLU B 314
ARG B 302
LEU B 303
ARG B 304
 None
 1.10A 5l6eA-3cuqB:
undetectable
5l6eB-3cuqB:
undetectable		 5l6eA-3cuqB:
22.27
5l6eB-3cuqB:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 3cuq VACUOLAR-SORTING
PROTEIN SNF8
(Homo
sapiens) 		5 / 12 LEU A 236
ALA A 222
LEU A 213
ALA A 187
ILE A 198
 None
 1.07A 5nm5B-3cuqA:
undetectable		 5nm5B-3cuqA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3cuq VACUOLAR-SORTING
PROTEIN SNF8
VACUOLAR
PROTEIN-SORTING-ASSO
CIATED PROTEIN 36
(Homo
sapiens;
Homo
sapiens) 		5 / 12 GLY B 225
TRP A  87
SER B 283
TYR A  98
ARG B 232
 None
 1.31A 5ttgA-3cuqB:
undetectable		 5ttgA-3cuqB:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUZ_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3cuq VACUOLAR-SORTING
PROTEIN SNF8
VACUOLAR
PROTEIN-SORTING-ASSO
CIATED PROTEIN 36
(Homo
sapiens;
Homo
sapiens) 		5 / 12 GLY B 225
TRP A  87
SER B 283
TYR A  98
ARG B 232
 None
 1.29A 5tuzB-3cuqB:
undetectable		 5tuzB-3cuqB:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3cuq VACUOLAR-SORTING
PROTEIN SNF8
VACUOLAR
PROTEIN-SORTING-ASSO
CIATED PROTEIN 36
(Homo
sapiens;
Homo
sapiens) 		5 / 12 GLY B 225
TRP A  87
SER B 283
TYR A  98
ARG B 232
 None
 1.30A 5v9jA-3cuqB:
undetectable		 5v9jA-3cuqB:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSF_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3cuq VACUOLAR-SORTING
PROTEIN SNF8
VACUOLAR
PROTEIN-SORTING-ASSO
CIATED PROTEIN 36
(Homo
sapiens;
Homo
sapiens) 		5 / 12 GLY B 225
TRP A  87
SER B 283
TYR A  98
ARG B 232
 None
 1.28A 5vsfB-3cuqB:
undetectable		 5vsfB-3cuqB:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)		 3cuq VACUOLAR-SORTING
PROTEIN SNF8
(Homo
sapiens) 		4 / 6 ARG A 208
MET A 178
ASN A 177
ASP A 179
 None
 1.47A 6dhbA-3cuqA:
undetectable		 6dhbA-3cuqA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 3cuq VACUOLAR-SORTING
PROTEIN SNF8
(Homo
sapiens) 		5 / 12 ILE A 169
LEU A 184
GLY A 117
ASN A 115
ALA A 174
 None
 1.27A 6r2eH-3cuqA:
undetectable		 6r2eH-3cuqA:
23.62