SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cux'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 3cux MALATE SYNTHASE
(Bacillus
anthracis) 		4 / 7 TRP A 363
GLY A 272
LEU A 245
LYS A 212
 None
None
MG  A   1 ( 4.9A)
MG  A   1 ( 4.2A)
 0.85A 1gtiD-3cuxA:
undetectable		 1gtiD-3cuxA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 3cux MALATE SYNTHASE
(Bacillus
anthracis) 		4 / 7 TYR A 209
VAL A 312
GLU A  90
LEU A  84
 None
 1.01A 1j96B-3cuxA:
5.1		 1j96B-3cuxA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 3cux MALATE SYNTHASE
(Bacillus
anthracis) 		5 / 12 THR A 362
GLY A 325
GLY A 272
ASP A 360
ASN A 378
 None
 1.15A 1n2xA-3cuxA:
undetectable		 1n2xA-3cuxA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_A_DVAA6_0
(GRAMICIDIN A)		 3cux MALATE SYNTHASE
(Bacillus
anthracis) 		3 / 3 ALA A 452
VAL A 454
TRP A 457
 None
 0.77A 1nt5A-3cuxA:
undetectable		 1nt5A-3cuxA:
3.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_B_DVAB6_0
(GRAMICIDIN A)		 3cux MALATE SYNTHASE
(Bacillus
anthracis) 		3 / 3 ALA A 452
VAL A 454
TRP A 457
 None
 0.77A 1nt5B-3cuxA:
undetectable		 1nt5B-3cuxA:
3.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 3cux MALATE SYNTHASE
(Bacillus
anthracis) 		3 / 3 ASP A 275
THR A 248
GLU A 218
 MG  A   1 (-3.3A)
None
None
 0.81A 1pj7A-3cuxA:
undetectable		 1pj7A-3cuxA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_1
(ESTROGEN RECEPTOR)		 3cux MALATE SYNTHASE
(Bacillus
anthracis) 		5 / 12 ALA A 504
GLU A 503
LEU A 507
LEU A 429
GLY A 433
 None
 0.92A 2jfaB-3cuxA:
undetectable		 2jfaB-3cuxA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PK4_A_ACAA100_1
(HUMAN PLASMINOGEN
KRINGLE 4)		 3cux MALATE SYNTHASE
(Bacillus
anthracis) 		4 / 7 ASP A 117
ASP A 443
PHE A 278
ARG A 451
 MG  A   1 ( 4.7A)
None
None
None
 1.27A 2pk4A-3cuxA:
undetectable		 2pk4A-3cuxA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 3cux MALATE SYNTHASE
(Bacillus
anthracis) 		3 / 3 ARG A  48
GLU A  39
SER A 215
 None
 0.77A 2xkkA-3cuxA:
undetectable
2xkkC-3cuxA:
2.5		 2xkkA-3cuxA:
23.33
2xkkC-3cuxA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YDO_A_ADNA400_1
(ADENOSINE RECEPTOR
A2A)		 3cux MALATE SYNTHASE
(Bacillus
anthracis) 		5 / 12 GLU A 393
LEU A 310
ILE A 313
SER A 309
HIS A 359
 None
 1.49A 2ydoA-3cuxA:
undetectable		 2ydoA-3cuxA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 3cux MALATE SYNTHASE
(Bacillus
anthracis) 		4 / 7 LEU A 245
GLU A 247
ASP A 275
THR A  92
 MG  A   1 ( 4.9A)
MG  A   1 (-2.6A)
MG  A   1 (-3.3A)
None
 1.34A 3dzgB-3cuxA:
undetectable		 3dzgB-3cuxA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 3cux MALATE SYNTHASE
(Bacillus
anthracis) 		5 / 12 THR A 506
THR A 505
LEU A 429
ILE A 528
LEU A 484
 None
 1.25A 3gwxB-3cuxA:
undetectable		 3gwxB-3cuxA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA702_1
(CARBONIC ANHYDRASE 2)		 3cux MALATE SYNTHASE
(Bacillus
anthracis) 		4 / 7 VAL A 159
TYR A 207
LYS A  82
PRO A  81
 None
 1.06A 3hs4A-3cuxA:
undetectable		 3hs4A-3cuxA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 3cux MALATE SYNTHASE
(Bacillus
anthracis) 		5 / 10 ILE A 422
SER A 450
GLY A 421
LYS A 480
LEU A 484
 None
 1.41A 3ik6B-3cuxA:
undetectable
3ik6E-3cuxA:
undetectable		 3ik6B-3cuxA:
18.71
3ik6E-3cuxA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 3cux MALATE SYNTHASE
(Bacillus
anthracis) 		5 / 10 LYS A 480
LEU A 484
ILE A 422
SER A 450
GLY A 421
 None
 1.28A 3ik6B-3cuxA:
undetectable
3ik6E-3cuxA:
undetectable		 3ik6B-3cuxA:
18.71
3ik6E-3cuxA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 3cux MALATE SYNTHASE
(Bacillus
anthracis) 		5 / 10 LYS A 480
LEU A 484
ILE A 422
SER A 450
GLY A 421
 None
 1.29A 3iluB-3cuxA:
undetectable
3iluE-3cuxA:
undetectable		 3iluB-3cuxA:
18.71
3iluE-3cuxA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KIV_A_ACAA100_1
(APOLIPOPROTEIN)		 3cux MALATE SYNTHASE
(Bacillus
anthracis) 		4 / 7 ASP A 117
ASP A 443
PHE A 278
ARG A 451
 MG  A   1 ( 4.7A)
None
None
None
 1.37A 3kivA-3cuxA:
undetectable		 3kivA-3cuxA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2U_A_ELVA397_1
(INTEGRASE)		 3cux MALATE SYNTHASE
(Bacillus
anthracis) 		4 / 5 ASP A 275
ASP A 117
PRO A 211
GLU A 247
 MG  A   1 (-3.3A)
MG  A   1 ( 4.7A)
None
MG  A   1 (-2.6A)
 1.31A 3l2uA-3cuxA:
0.0		 3l2uA-3cuxA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		 3cux MALATE SYNTHASE
(Bacillus
anthracis) 		4 / 7 ASP A 275
ASP A 117
PRO A 211
GLU A 247
 MG  A   1 (-3.3A)
MG  A   1 ( 4.7A)
None
MG  A   1 (-2.6A)
 1.27A 3l2vA-3cuxA:
undetectable		 3l2vA-3cuxA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2W_A_ELVA397_1
(INTEGRASE)		 3cux MALATE SYNTHASE
(Bacillus
anthracis) 		4 / 5 ASP A 275
ASP A 117
PRO A 211
GLU A 247
 MG  A   1 (-3.3A)
MG  A   1 ( 4.7A)
None
MG  A   1 (-2.6A)
 1.30A 3l2wA-3cuxA:
undetectable		 3l2wA-3cuxA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 3cux MALATE SYNTHASE
(Bacillus
anthracis) 		3 / 3 LEU A 160
ARG A  97
ASN A 119
 None
 0.78A 3qxvD-3cuxA:
undetectable		 3qxvD-3cuxA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 3cux MALATE SYNTHASE
(Bacillus
anthracis) 		4 / 7 ASP A 275
ASP A 117
PRO A 211
GLU A 247
 MG  A   1 (-3.3A)
MG  A   1 ( 4.7A)
None
MG  A   1 (-2.6A)
 1.26A 3s3oA-3cuxA:
undetectable		 3s3oA-3cuxA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3cux MALATE SYNTHASE
(Bacillus
anthracis) 		3 / 3 TYR A 424
LEU A 479
LYS A 480
 None
 0.67A 3sueD-3cuxA:
undetectable		 3sueD-3cuxA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 3cux MALATE SYNTHASE
(Bacillus
anthracis) 		4 / 6 HIS A 317
GLU A 354
ASP A 360
ASN A 270
 None
 1.15A 3vywA-3cuxA:
undetectable		 3vywA-3cuxA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 3cux MALATE SYNTHASE
(Bacillus
anthracis) 		3 / 3 LEU A 169
GLU A 171
SER A 184
 None
 0.64A 4ccqA-3cuxA:
undetectable		 4ccqA-3cuxA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 3cux MALATE SYNTHASE
(Bacillus
anthracis) 		3 / 3 LYS A 311
THR A 315
ILE A  70
 None
 0.88A 4e0fB-3cuxA:
undetectable		 4e0fB-3cuxA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3cux MALATE SYNTHASE
(Bacillus
anthracis) 		4 / 8 LEU A 281
ARG A 295
VAL A 420
GLY A 421
 None
 1.02A 4klrB-3cuxA:
undetectable		 4klrB-3cuxA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMU_C_RFPC1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3cux MALATE SYNTHASE
(Bacillus
anthracis) 		5 / 12 GLN A 230
ASP A 264
HIS A 265
LEU A 200
PRO A  81
 None
 1.27A 4kmuC-3cuxA:
1.6		 4kmuC-3cuxA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMU_H_RFPH1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3cux MALATE SYNTHASE
(Bacillus
anthracis) 		5 / 12 GLN A 230
ASP A 264
HIS A 265
LEU A 200
PRO A  81
 None
 1.33A 4kmuH-3cuxA:
0.0		 4kmuH-3cuxA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3cux MALATE SYNTHASE
(Bacillus
anthracis) 		4 / 5 PRO A 164
GLY A 166
ASP A  96
ASP A 117
 None
None
None
MG  A   1 ( 4.7A)
 1.06A 4n48B-3cuxA:
undetectable		 4n48B-3cuxA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3cux MALATE SYNTHASE
(Bacillus
anthracis) 		4 / 6 ILE A 277
PHE A 278
ILE A  55
LEU A 292
 None
 0.69A 4o8fB-3cuxA:
undetectable		 4o8fB-3cuxA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3cux MALATE SYNTHASE
(Bacillus
anthracis) 		4 / 7 LEU A 133
ALA A 136
LEU A 160
ALA A 103
 None
 0.59A 4z90F-3cuxA:
1.4
4z90G-3cuxA:
1.4
4z90H-3cuxA:
undetectable
4z90J-3cuxA:
undetectable		 4z90F-3cuxA:
22.48
4z90G-3cuxA:
22.48
4z90H-3cuxA:
22.48
4z90J-3cuxA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3cux MALATE SYNTHASE
(Bacillus
anthracis) 		4 / 7 LEU A 160
ALA A 103
LEU A 133
ALA A 136
 None
 0.56A 4z90F-3cuxA:
1.4
4z90G-3cuxA:
1.4
4z90H-3cuxA:
undetectable
4z90J-3cuxA:
undetectable		 4z90F-3cuxA:
22.48
4z90G-3cuxA:
22.48
4z90H-3cuxA:
22.48
4z90J-3cuxA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		 3cux MALATE SYNTHASE
(Bacillus
anthracis) 		5 / 9 ALA A 113
ASP A  96
GLY A 129
LEU A 133
LEU A 160
 None
 1.18A 5dqfA-3cuxA:
undetectable		 5dqfA-3cuxA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 3cux MALATE SYNTHASE
(Bacillus
anthracis) 		4 / 5 ALA A 242
VAL A 244
PHE A 226
ILE A 258
 None
 1.05A 5of1B-3cuxA:
undetectable		 5of1B-3cuxA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3cux MALATE SYNTHASE
(Bacillus
anthracis) 		4 / 5 TYR A 191
VAL A 137
ASP A 135
ALA A 136
 None
 1.05A 5otrA-3cuxA:
undetectable		 5otrA-3cuxA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAC_C_RFPC3001_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3cux MALATE SYNTHASE
(Bacillus
anthracis) 		5 / 12 GLN A 230
ASP A 264
HIS A 265
LEU A 200
PRO A  81
 None
 1.35A 5uacC-3cuxA:
0.0		 5uacC-3cuxA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CCV_C_RFPC1205_1
(-)		 3cux MALATE SYNTHASE
(Bacillus
anthracis) 		5 / 12 GLN A 230
ASP A 264
HIS A 265
LEU A 200
PRO A  81
 None
 1.29A 6ccvC-3cuxA:
0.0		 6ccvC-3cuxA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 3cux MALATE SYNTHASE
(Bacillus
anthracis) 		5 / 8 GLY A 413
VAL A 298
GLY A 421
SER A 450
ALA A 452
 None
 1.43A 6hu9H-3cuxA:
undetectable
6hu9e-3cuxA:
0.9		 6hu9H-3cuxA:
14.32
6hu9e-3cuxA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3cux MALATE SYNTHASE
(Bacillus
anthracis) 		4 / 8 HIS A 250
GLU A 247
ASP A 275
GLU A 448
 None
MG  A   1 (-2.6A)
MG  A   1 (-3.3A)
None
 1.22A 6mn4C-3cuxA:
undetectable		 6mn4C-3cuxA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 3cux MALATE SYNTHASE
(Bacillus
anthracis) 		3 / 3 ILE A  91
THR A  92
PRO A 367
 None
 0.66A 6ncsA-3cuxA:
11.9		 6ncsA-3cuxA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3cux MALATE SYNTHASE
(Bacillus
anthracis) 		3 / 3 ARG A 451
PHE A 284
PHE A 520
 None
 0.76A 6nknC-3cuxA:
undetectable
6nknJ-3cuxA:
undetectable		 6nknC-3cuxA:
16.70
6nknJ-3cuxA:
9.57