SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cv2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		 3cv2 MALATE SYNTHASE A
(Escherichia
coli) 		3 / 3 ASP A 304
PHE A 307
VAL A 301
 None
 0.74A 1kijB-3cv2A:
undetectable		 1kijB-3cv2A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 3cv2 MALATE SYNTHASE A
(Escherichia
coli) 		4 / 4 HIS A 361
ALA A 326
PHE A 325
GLY A 363
 None
 1.42A 1mj2B-3cv2A:
undetectable		 1mj2B-3cv2A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 3cv2 MALATE SYNTHASE A
(Escherichia
coli) 		4 / 4 HIS A 361
ALA A 326
PHE A 325
GLY A 363
 None
 1.37A 1mj2D-3cv2A:
undetectable		 1mj2D-3cv2A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 3cv2 MALATE SYNTHASE A
(Escherichia
coli) 		4 / 4 HIS A 361
ALA A 326
PHE A 325
GLY A 363
 None
 1.40A 1mjoB-3cv2A:
undetectable		 1mjoB-3cv2A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 3cv2 MALATE SYNTHASE A
(Escherichia
coli) 		4 / 4 HIS A 361
ALA A 326
PHE A 325
GLY A 363
 None
 1.42A 1mjoA-3cv2A:
undetectable		 1mjoA-3cv2A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_B_ADNB1301_1
(SUGAR KINASE MJ0406)		 3cv2 MALATE SYNTHASE A
(Escherichia
coli) 		4 / 7 GLY A 329
GLY A 328
ASN A 273
PHE A 379
 None
 0.72A 2c49B-3cv2A:
undetectable		 2c49B-3cv2A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3cv2 MALATE SYNTHASE A
(Escherichia
coli) 		4 / 6 PHE A 281
ARG A 298
ASN A 309
LEU A 355
 None
 1.30A 2nyrA-3cv2A:
undetectable		 2nyrA-3cv2A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PK4_A_ACAA100_1
(HUMAN PLASMINOGEN
KRINGLE 4)		 3cv2 MALATE SYNTHASE A
(Escherichia
coli) 		4 / 7 ASP A 120
ASP A 447
PHE A 281
ARG A 455
 MG  A   1 ( 4.7A)
CSO  A 438 ( 4.8A)
None
None
 1.30A 2pk4A-3cv2A:
undetectable		 2pk4A-3cv2A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 3cv2 MALATE SYNTHASE A
(Escherichia
coli) 		5 / 10 ASP A 447
ILE A 249
LEU A 524
ILE A 261
GLY A 169
 CSO  A 438 ( 4.8A)
None
None
None
None
 1.24A 2v0mA-3cv2A:
undetectable		 2v0mA-3cv2A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 3cv2 MALATE SYNTHASE A
(Escherichia
coli) 		5 / 12 ALA A 425
LEU A 524
LEU A 510
ARG A 503
ALA A 431
 None
 1.09A 3dfrA-3cv2A:
undetectable		 3dfrA-3cv2A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 3cv2 MALATE SYNTHASE A
(Escherichia
coli) 		4 / 7 LEU A 248
GLU A 250
ASP A 278
THR A  95
 OXL  A1000 ( 4.7A)
MG  A   1 ( 2.6A)
MG  A   1 ( 3.1A)
None
 1.26A 3dzgB-3cv2A:
2.5		 3dzgB-3cv2A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KIV_A_ACAA100_1
(APOLIPOPROTEIN)		 3cv2 MALATE SYNTHASE A
(Escherichia
coli) 		4 / 7 ASP A 120
ASP A 447
PHE A 281
ARG A 455
 MG  A   1 ( 4.7A)
CSO  A 438 ( 4.8A)
None
None
 1.39A 3kivA-3cv2A:
undetectable		 3kivA-3cv2A:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 3cv2 MALATE SYNTHASE A
(Escherichia
coli) 		5 / 12 SER A 312
ILE A 249
ASN A 359
LEU A 390
ASN A 273
 None
 1.16A 3q87B-3cv2A:
undetectable		 3q87B-3cv2A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 3cv2 MALATE SYNTHASE A
(Escherichia
coli) 		3 / 3 LEU A 172
GLU A 174
SER A 187
 None
 0.61A 4ccqA-3cv2A:
undetectable		 4ccqA-3cv2A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3cv2 MALATE SYNTHASE A
(Escherichia
coli) 		5 / 12 ALA A 245
TRP A 225
PHE A 191
PHE A 229
PHE A  32
 None
 1.41A 4iaqA-3cv2A:
undetectable		 4iaqA-3cv2A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		 3cv2 MALATE SYNTHASE A
(Escherichia
coli) 		5 / 12 GLY A 329
GLY A 328
ASN A 273
PHE A 379
GLN A 389
 None
 1.06A 4ubeA-3cv2A:
undetectable		 4ubeA-3cv2A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3cv2 MALATE SYNTHASE A
(Escherichia
coli) 		4 / 7 LEU A 136
ALA A 139
LEU A 163
ALA A 106
 None
None
None
COA  A1002 (-3.6A)
 0.65A 4z90F-3cv2A:
2.7
4z90G-3cv2A:
1.9
4z90H-3cv2A:
1.8
4z90J-3cv2A:
3.1		 4z90F-3cv2A:
22.72
4z90G-3cv2A:
22.72
4z90H-3cv2A:
22.72
4z90J-3cv2A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3cv2 MALATE SYNTHASE A
(Escherichia
coli) 		4 / 7 LEU A 163
ALA A 106
LEU A 136
ALA A 139
 None
COA  A1002 (-3.6A)
None
None
 0.61A 4z90F-3cv2A:
2.7
4z90G-3cv2A:
1.9
4z90H-3cv2A:
1.8
4z90J-3cv2A:
3.1		 4z90F-3cv2A:
22.72
4z90G-3cv2A:
22.72
4z90H-3cv2A:
22.72
4z90J-3cv2A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3cv2 MALATE SYNTHASE A
(Escherichia
coli) 		3 / 3 THR A 216
HIS A  39
LEU A 188
 None
 0.77A 5axdA-3cv2A:
undetectable		 5axdA-3cv2A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3cv2 MALATE SYNTHASE A
(Escherichia
coli) 		3 / 3 THR A 216
HIS A  39
LEU A 188
 None
 0.74A 5axdC-3cv2A:
undetectable		 5axdC-3cv2A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 3cv2 MALATE SYNTHASE A
(Escherichia
coli) 		5 / 12 LEU A 172
GLY A 169
SER A 121
TYR A 428
TYR A 529
 None
None
CSO  A 438 ( 4.8A)
None
None
 1.22A 5czyA-3cv2A:
undetectable		 5czyA-3cv2A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3cv2 MALATE SYNTHASE A
(Escherichia
coli) 		4 / 5 TYR A 428
LEU A 532
PRO A 124
LEU A 510
 None
 1.36A 5eshA-3cv2A:
2.1		 5eshA-3cv2A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3cv2 MALATE SYNTHASE A
(Escherichia
coli) 		3 / 3 MET A 258
GLN A 257
ARG A  74
 None
 0.82A 5ewzB-3cv2A:
undetectable		 5ewzB-3cv2A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		 3cv2 MALATE SYNTHASE A
(Escherichia
coli) 		5 / 12 GLY A 443
ILE A 334
PHE A 333
VAL A 424
LEU A 371
 None
 1.06A 5nz0A-3cv2A:
undetectable		 5nz0A-3cv2A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3cv2 MALATE SYNTHASE A
(Escherichia
coli) 		4 / 5 TYR A 194
VAL A 140
ASP A 138
ALA A 139
 None
 1.05A 5otrA-3cv2A:
undetectable		 5otrA-3cv2A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 3cv2 MALATE SYNTHASE A
(Escherichia
coli) 		5 / 12 LEU A 248
ASN A 273
LEU A 247
GLY A 271
VAL A 270
 OXL  A1000 ( 4.7A)
None
None
None
None
 1.09A 5uc1B-3cv2A:
undetectable		 5uc1B-3cv2A:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3cv2 MALATE SYNTHASE A
(Escherichia
coli) 		3 / 3 THR A 364
MET A 327
HIS A 361
 None
 1.00A 5uunA-3cv2A:
undetectable		 5uunA-3cv2A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 3cv2 MALATE SYNTHASE A
(Escherichia
coli) 		3 / 3 ARG A 509
ARG A 503
ARG A 530
 None
 1.01A 5vcgA-3cv2A:
undetectable		 5vcgA-3cv2A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3cv2 MALATE SYNTHASE A
(Escherichia
coli) 		4 / 5 ARG A 455
LEU A 520
GLN A 460
PHE A 523
 None
 1.43A 6nmpP-3cv2A:
undetectable
6nmpW-3cv2A:
undetectable		 6nmpP-3cv2A:
19.52
6nmpW-3cv2A:
9.46