SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cvh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 3cvh 25-D1.16 HEAVY CHAIN
25-D1.16 LIGHT CHAIN
(Mus
musculus) 		7 / 12 TYR L  35
GLN L  88
LEU L  95
PHE L  97
VAL H  36
ALA H  96
TRP H 110
 None
 0.70A 1h8sA-3cvhL:
22.1		 1h8sA-3cvhL:
41.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3cvh 25-D1.16 LIGHT CHAIN
(Mus
musculus) 		4 / 5 LEU L 178
GLY L 127
PRO L 119
VAL L 131
 None
 0.91A 2aojA-3cvhL:
undetectable		 2aojA-3cvhL:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 3cvh 25-D1.16 HEAVY CHAIN
(Mus
musculus) 		5 / 11 LEU H 145
VAL H 170
GLY H 164
VAL H 190
VAL H 188
 None
 1.05A 2nnpB-3cvhH:
undetectable		 2nnpB-3cvhH:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 3cvh 25-D1.16 LIGHT CHAIN
(Mus
musculus) 		4 / 5 VAL L 131
VAL L 158
GLY L 157
TRP L 147
 None
 1.14A 2p2fA-3cvhL:
undetectable		 2p2fA-3cvhL:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)		 3cvh 25-D1.16 HEAVY CHAIN
25-D1.16 LIGHT CHAIN
(Mus
musculus;
Mus
musculus) 		4 / 8 MET L 174
LEU L 135
SER H 185
VAL L 158
 None
 0.97A 2qd2A-3cvhL:
undetectable		 2qd2A-3cvhL:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_A_5FWA601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 3cvh 25-D1.16 HEAVY CHAIN
(Mus
musculus) 		5 / 12 VAL H 170
VAL H 188
SER H 186
ASN H 203
ASN H 162
 None
 1.40A 2y03A-3cvhH:
undetectable		 2y03A-3cvhH:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_B_5FWB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 3cvh 25-D1.16 HEAVY CHAIN
(Mus
musculus) 		5 / 12 VAL H 170
VAL H 188
SER H 186
ASN H 203
ASN H 162
 None
 1.43A 2y03B-3cvhH:
undetectable		 2y03B-3cvhH:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_2
(ADENOSYLHOMOCYSTEINA
SE)		 3cvh 25-D1.16 HEAVY CHAIN
(Mus
musculus) 		3 / 3 THR H 117
GLU H 155
HIS H 206
 None
 0.79A 3g1uB-3cvhH:
undetectable		 3g1uB-3cvhH:
20.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 3cvh 25-D1.16 LIGHT CHAIN
(Mus
musculus) 		4 / 5 TYR L  35
GLN L  88
LEU L  95
PHE L  97
 None
 0.45A 3ls4L-3cvhL:
26.3		 3ls4L-3cvhL:
79.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NYA_A_JTZA1203_1
(BETA-2 ADRENERGIC
RECEPTOR, LYSOZYME)		 3cvh 25-D1.16 HEAVY CHAIN
(Mus
musculus) 		5 / 12 VAL H 170
VAL H 188
SER H 186
ASN H 203
ASN H 162
 None
 1.41A 3nyaA-3cvhH:
undetectable		 3nyaA-3cvhH:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 3cvh 25-D1.16 LIGHT CHAIN
(Mus
musculus) 		5 / 8 ALA L  83
VAL L  82
ASP L  81
LEU L  77
LEU L  72
 None
 1.47A 3roxA-3cvhL:
undetectable		 3roxA-3cvhL:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3cvh 25-D1.16 LIGHT CHAIN
(Mus
musculus) 		3 / 3 LYS L   1
GLU L  26
TRP L  91
 None
 1.45A 3v4tH-3cvhL:
undetectable		 3v4tH-3cvhL:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ABZ_A_T1CA1209_1
(TETRACYCLINE
REPRESSOR CLASS D)		 3cvh 25-D1.16 HEAVY CHAIN
25-D1.16 LIGHT CHAIN
(Mus
musculus) 		5 / 12 SER H  43
PHE L  97
ARG L  44
GLN L  37
LEU L  72
 None
 1.49A 4abzA-3cvhH:
undetectable		 4abzA-3cvhH:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3cvh 25-D1.16 HEAVY CHAIN
25-D1.16 LIGHT CHAIN
(Mus
musculus;
Mus
musculus) 		3 / 3 GLY L  49
SER L  48
TRP H 106
 None
 0.88A 4e7cD-3cvhL:
undetectable		 4e7cD-3cvhL:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		 3cvh 25-D1.16 HEAVY CHAIN
(Mus
musculus) 		5 / 10 VAL H 170
VAL H 188
SER H 186
ASN H 203
ASN H 162
 None
 1.49A 4ldoA-3cvhH:
undetectable		 4ldoA-3cvhH:
18.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M7K_H_ACTH302_0
(10H10 HEAVY CHAIN)		 3cvh 25-D1.16 HEAVY CHAIN
(Mus
musculus) 		4 / 5 VAL H   1
TYR H  26
ARG H  97
TYR H 109
 None
 0.25A 4m7kH-3cvhH:
22.2		 4m7kH-3cvhH:
68.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OJ0_A_9WTA801_0
(PENICILLIN-BINDING
PROTEIN 2X)		 3cvh 25-D1.16 LIGHT CHAIN
(Mus
musculus) 		5 / 12 ARG L  67
GLN L  89
SER L  62
GLY L  63
THR L  51
 None
 1.07A 5oj0A-3cvhL:
undetectable		 5oj0A-3cvhL:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 3cvh 25-D1.16 LIGHT CHAIN
(Mus
musculus) 		3 / 3 ARG L  44
PRO L  58
TYR L  85
 None
 1.02A 5tzoB-3cvhL:
undetectable		 5tzoB-3cvhL:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7M_B_68HB405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 3cvh 25-D1.16 HEAVY CHAIN
(Mus
musculus) 		5 / 12 VAL H 170
VAL H 188
SER H 186
ASN H 203
ASN H 162
 None
 1.46A 6h7mB-3cvhH:
undetectable		 6h7mB-3cvhH:
19.40