SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cvj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 3cvj PUTATIVE
PHOSPHOHEPTOSE
ISOMERASE
(Bacillus
halodurans) 		4 / 7 GLY A  50
ASP A 175
SER A  52
ALA A 189
 None
 0.83A 1gxsA-3cvjA:
2.4
1gxsB-3cvjA:
undetectable		 1gxsA-3cvjA:
19.43
1gxsB-3cvjA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3cvj PUTATIVE
PHOSPHOHEPTOSE
ISOMERASE
(Bacillus
halodurans) 		4 / 4 ALA A  71
VAL A  46
ALA A  56
HIS A  53
 None
None
None
MG  A 243 (-3.5A)
 1.17A 1q23F-3cvjA:
undetectable		 1q23F-3cvjA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3cvj PUTATIVE
PHOSPHOHEPTOSE
ISOMERASE
(Bacillus
halodurans) 		4 / 4 ALA A  71
VAL A  46
ALA A  56
HIS A  53
 None
None
None
MG  A 243 (-3.5A)
 1.22A 1q23K-3cvjA:
undetectable		 1q23K-3cvjA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 3cvj PUTATIVE
PHOSPHOHEPTOSE
ISOMERASE
(Bacillus
halodurans) 		5 / 11 VAL A  34
VAL A 110
GLU A 205
LEU A 167
ILE A 138
 None
 1.39A 1t6zB-3cvjA:
undetectable		 1t6zB-3cvjA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3cvj PUTATIVE
PHOSPHOHEPTOSE
ISOMERASE
(Bacillus
halodurans) 		5 / 12 ILE A  59
LEU A 202
GLY A 195
SER A 191
ILE A  55
 None
 1.07A 2ogyB-3cvjA:
undetectable		 2ogyB-3cvjA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 3cvj PUTATIVE
PHOSPHOHEPTOSE
ISOMERASE
(Bacillus
halodurans) 		3 / 3 ASN A 169
ASP A 192
ARG A  91
 None
 0.83A 3k13C-3cvjA:
undetectable		 3k13C-3cvjA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD392_1
(TETX2 PROTEIN)		 3cvj PUTATIVE
PHOSPHOHEPTOSE
ISOMERASE
(Bacillus
halodurans) 		4 / 5 HIS A  32
SER A  35
GLN A 213
VAL A  38
 None
 1.29A 4a99D-3cvjA:
2.2		 4a99D-3cvjA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 3cvj PUTATIVE
PHOSPHOHEPTOSE
ISOMERASE
(Bacillus
halodurans) 		4 / 6 ALA A 201
ILE A 114
GLY A 195
ILE A  27
 None
 0.66A 4r21A-3cvjA:
undetectable		 4r21A-3cvjA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_A_ACTA202_0
(NITROGEN REGULATORY
PROTEIN P-II)		 3cvj PUTATIVE
PHOSPHOHEPTOSE
ISOMERASE
(Bacillus
halodurans) 		4 / 4 VAL A  38
GLY A  42
ARG A  43
VAL A  69
 None
 1.40A 5d4nA-3cvjA:
undetectable
5d4nB-3cvjA:
undetectable		 5d4nA-3cvjA:
18.53
5d4nB-3cvjA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 3cvj PUTATIVE
PHOSPHOHEPTOSE
ISOMERASE
(Bacillus
halodurans) 		3 / 3 GLY A  65
GLY A  64
GLN A 200
 None
 0.46A 5imsA-3cvjA:
3.4		 5imsA-3cvjA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3cvj PUTATIVE
PHOSPHOHEPTOSE
ISOMERASE
(Bacillus
halodurans) 		3 / 3 VAL A 219
HIS A 208
VAL A 211
 None
 0.52A 5jmnC-3cvjA:
undetectable		 5jmnC-3cvjA:
12.79