SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cvo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 3cvo METHYLTRANSFERASE-LI
KE PROTEIN OF
UNKNOWN FUNCTION
(Ruegeria
pomeroyi) 		4 / 8 VAL A 124
LEU A 150
SER A  41
VAL A  44
 None
None
None
EDO  A 214 ( 4.5A)
 1.15A 1jtvA-3cvoA:
7.0		 1jtvA-3cvoA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3cvo METHYLTRANSFERASE-LI
KE PROTEIN OF
UNKNOWN FUNCTION
(Ruegeria
pomeroyi) 		5 / 12 ILE A  33
LEU A  34
ALA A  45
SER A  38
GLU A  35
 None
EDO  A 205 ( 4.3A)
None
None
None
 1.30A 2a58B-3cvoA:
undetectable
2a58C-3cvoA:
undetectable		 2a58B-3cvoA:
22.27
2a58C-3cvoA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 3cvo METHYLTRANSFERASE-LI
KE PROTEIN OF
UNKNOWN FUNCTION
(Ruegeria
pomeroyi) 		3 / 3 GLY A  37
GLU A  57
ASP A 128
 None
 0.25A 2b25B-3cvoA:
10.6		 2b25B-3cvoA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 3cvo METHYLTRANSFERASE-LI
KE PROTEIN OF
UNKNOWN FUNCTION
(Ruegeria
pomeroyi) 		5 / 12 ILE A 143
ALA A 140
ALA A 136
LEU A 111
TYR A  36
 None
 1.14A 2japC-3cvoA:
6.8		 2japC-3cvoA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 3cvo METHYLTRANSFERASE-LI
KE PROTEIN OF
UNKNOWN FUNCTION
(Ruegeria
pomeroyi) 		3 / 3 SER A  41
GLU A  57
ASP A 128
 None
 0.34A 2zthA-3cvoA:
14.7		 2zthA-3cvoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 3cvo METHYLTRANSFERASE-LI
KE PROTEIN OF
UNKNOWN FUNCTION
(Ruegeria
pomeroyi) 		3 / 3 MET A  66
GLU A  35
ASP A 152
 None
 1.10A 3a25A-3cvoA:
10.1		 3a25A-3cvoA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 3cvo METHYLTRANSFERASE-LI
KE PROTEIN OF
UNKNOWN FUNCTION
(Ruegeria
pomeroyi) 		4 / 7 GLY A  39
ALA A  45
VAL A  53
ILE A  83
 None
 0.73A 3a2qA-3cvoA:
undetectable		 3a2qA-3cvoA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 3cvo METHYLTRANSFERASE-LI
KE PROTEIN OF
UNKNOWN FUNCTION
(Ruegeria
pomeroyi) 		4 / 6 GLY A  37
SER A  41
GLU A  57
ASP A 128
 None
 0.41A 3a7eA-3cvoA:
13.4		 3a7eA-3cvoA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 3cvo METHYLTRANSFERASE-LI
KE PROTEIN OF
UNKNOWN FUNCTION
(Ruegeria
pomeroyi) 		3 / 3 SER A  41
GLU A  57
ASP A 128
 None
 0.22A 3bwmA-3cvoA:
13.3		 3bwmA-3cvoA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 3cvo METHYLTRANSFERASE-LI
KE PROTEIN OF
UNKNOWN FUNCTION
(Ruegeria
pomeroyi) 		3 / 3 SER A  41
GLU A  57
ASP A 128
 None
 0.26A 3bwyA-3cvoA:
13.3		 3bwyA-3cvoA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3cvo METHYLTRANSFERASE-LI
KE PROTEIN OF
UNKNOWN FUNCTION
(Ruegeria
pomeroyi) 		5 / 12 GLY A 134
CYH A 135
LEU A  34
VAL A  56
LEU A 167
 None
None
EDO  A 205 ( 4.3A)
None
None
 1.20A 3g9eA-3cvoA:
undetectable		 3g9eA-3cvoA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S68_A_SAMA228_0
(CATECHOL
O-METHYLTRANSFERASE)		 3cvo METHYLTRANSFERASE-LI
KE PROTEIN OF
UNKNOWN FUNCTION
(Ruegeria
pomeroyi) 		5 / 10 GLU A  35
GLY A  37
SER A  41
GLU A  57
ASP A 128
 None
 0.71A 3s68A-3cvoA:
14.6		 3s68A-3cvoA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 3cvo METHYLTRANSFERASE-LI
KE PROTEIN OF
UNKNOWN FUNCTION
(Ruegeria
pomeroyi) 		4 / 5 ILE A  88
PRO A  97
LYS A 102
GLY A  89
 None
 1.13A 3tkdB-3cvoA:
undetectable		 3tkdB-3cvoA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 3cvo METHYLTRANSFERASE-LI
KE PROTEIN OF
UNKNOWN FUNCTION
(Ruegeria
pomeroyi) 		4 / 5 ILE A  88
PRO A  97
LYS A 102
GLY A  89
 None
 1.12A 3tkdA-3cvoA:
undetectable		 3tkdA-3cvoA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 3cvo METHYLTRANSFERASE-LI
KE PROTEIN OF
UNKNOWN FUNCTION
(Ruegeria
pomeroyi) 		4 / 7 LEU A 194
ALA A 140
VAL A 163
THR A 197
 None
 0.92A 4eyrA-3cvoA:
undetectable		 4eyrA-3cvoA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 3cvo METHYLTRANSFERASE-LI
KE PROTEIN OF
UNKNOWN FUNCTION
(Ruegeria
pomeroyi) 		3 / 3 SER A  41
GLU A  57
ASP A 128
 None
 0.28A 4xudA-3cvoA:
13.5		 4xudA-3cvoA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 3cvo METHYLTRANSFERASE-LI
KE PROTEIN OF
UNKNOWN FUNCTION
(Ruegeria
pomeroyi) 		4 / 5 GLY A  37
SER A  41
GLU A  57
ASP A 128
 None
 0.31A 4xueA-3cvoA:
13.6		 4xueA-3cvoA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 3cvo METHYLTRANSFERASE-LI
KE PROTEIN OF
UNKNOWN FUNCTION
(Ruegeria
pomeroyi) 		4 / 7 GLY A  37
SER A  41
GLU A  57
ASP A 128
 None
 0.26A 5n5dB-3cvoA:
13.5		 5n5dB-3cvoA:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA605_0
(ALPHA-AMYLASE)		 3cvo METHYLTRANSFERASE-LI
KE PROTEIN OF
UNKNOWN FUNCTION
(Ruegeria
pomeroyi) 		4 / 8 TYR A 154
GLY A 174
ILE A 173
ASP A 153
 None
 0.80A 6ag0A-3cvoA:
undetectable		 6ag0A-3cvoA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC605_0
(ALPHA-AMYLASE)		 3cvo METHYLTRANSFERASE-LI
KE PROTEIN OF
UNKNOWN FUNCTION
(Ruegeria
pomeroyi) 		4 / 8 TYR A 154
GLY A 174
ILE A 173
ASP A 153
 None
 0.78A 6ag0C-3cvoA:
undetectable		 6ag0C-3cvoA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 3cvo METHYLTRANSFERASE-LI
KE PROTEIN OF
UNKNOWN FUNCTION
(Ruegeria
pomeroyi) 		4 / 6 ASN A  82
VAL A  84
VAL A 113
THR A 116
 EDO  A 212 (-3.8A)
None
None
EDO  A 212 ( 3.9A)
 1.17A 6f32B-3cvoA:
3.4		 6f32B-3cvoA:
17.87