SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cvw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 3cvw RE11660P
(Drosophila
melanogaster) 		5 / 11 LEU A 296
LEU A 270
GLU A 232
LEU A 265
SER A 262
 None
None
None
FAD  A 521 (-4.4A)
FAD  A 521 (-3.2A)
 1.26A 1ictA-3cvwA:
undetectable
1ictC-3cvwA:
undetectable		 1ictA-3cvwA:
12.22
1ictC-3cvwA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 3cvw RE11660P
(Drosophila
melanogaster) 		5 / 11 LEU A 296
LEU A 270
GLU A 232
LEU A 265
THR A 259
 None
None
None
FAD  A 521 (-4.4A)
FAD  A 521 (-2.9A)
 1.17A 1ictA-3cvwA:
undetectable
1ictC-3cvwA:
undetectable		 1ictA-3cvwA:
12.22
1ictC-3cvwA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_B_SAMB200_0
(METHIONINE REPRESSOR)		 3cvw RE11660P
(Drosophila
melanogaster) 		5 / 11 GLU A 108
GLY A  15
LEU A  78
HIS A  10
LEU A  24
 None
 1.26A 1mjqA-3cvwA:
undetectable
1mjqB-3cvwA:
undetectable		 1mjqA-3cvwA:
11.99
1mjqB-3cvwA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1435_1
(CHITINASE)		 3cvw RE11660P
(Drosophila
melanogaster) 		3 / 3 TRP A 100
GLU A 193
TYR A 200
 None
 1.11A 2a3aA-3cvwA:
undetectable		 2a3aA-3cvwA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		 3cvw RE11660P
(Drosophila
melanogaster) 		4 / 6 ALA A 199
ASP A 196
GLU A 193
ARG A  41
 None
 1.39A 2ouzA-3cvwA:
undetectable		 2ouzA-3cvwA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA503_0
(CHORISMATE SYNTHASE)		 3cvw RE11660P
(Drosophila
melanogaster) 		4 / 5 THR A 140
ARG A 273
ALA A 272
ARG A  17
 None
 1.36A 2qhfA-3cvwA:
undetectable		 2qhfA-3cvwA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 3cvw RE11660P
(Drosophila
melanogaster) 		4 / 7 TYR A 114
ILE A  50
GLY A  49
PHE A  44
 None
FO1  A1422 (-4.4A)
None
FO1  A1422 (-4.1A)
 1.01A 2vctD-3cvwA:
undetectable		 2vctD-3cvwA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3cvw RE11660P
(Drosophila
melanogaster) 		4 / 8 THR A 140
ARG A  17
ASP A 399
LEU A 402
 None
None
None
FAD  A 521 (-4.1A)
 0.85A 2zw9A-3cvwA:
undetectable		 2zw9A-3cvwA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 3cvw RE11660P
(Drosophila
melanogaster) 		4 / 8 HIS A 369
ASN A 406
TRP A 409
TRP A 302
 FAD  A 521 (-4.4A)
FAD  A 521 (-3.3A)
None
None
 0.99A 3ccfA-3cvwA:
2.8		 3ccfA-3cvwA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3cvw RE11660P
(Drosophila
melanogaster) 		4 / 8 TYR A 159
LEU A 163
VAL A 166
GLU A 167
 None
 0.83A 4fgzA-3cvwA:
undetectable		 4fgzA-3cvwA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 3cvw RE11660P
(Drosophila
melanogaster) 		3 / 3 ARG A  17
GLU A 108
ASN A  21
 None
 0.90A 4imaD-3cvwA:
undetectable		 4imaD-3cvwA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 3cvw RE11660P
(Drosophila
melanogaster) 		3 / 3 ARG A  17
GLU A 108
ASN A  21
 None
 0.88A 4ip7D-3cvwA:
undetectable		 4ip7D-3cvwA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 3cvw RE11660P
(Drosophila
melanogaster) 		4 / 8 ILE A 141
VAL A 171
PRO A 172
VAL A 166
 None
 0.79A 4jltA-3cvwA:
undetectable		 4jltA-3cvwA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 3cvw RE11660P
(Drosophila
melanogaster) 		3 / 3 GLU A 255
TYR A 442
GLU A 360
 None
 0.79A 4ryaA-3cvwA:
undetectable		 4ryaA-3cvwA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)		 3cvw RE11660P
(Drosophila
melanogaster) 		4 / 5 ILE A  45
ILE A  96
ARG A  95
GLU A  91
 None
 1.16A 4zzcE-3cvwA:
undetectable		 4zzcE-3cvwA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		 3cvw RE11660P
(Drosophila
melanogaster) 		4 / 7 PRO A  89
VAL A  92
ILE A  96
VAL A  85
 None
 0.78A 5bmvC-3cvwA:
undetectable		 5bmvC-3cvwA:
22.92