SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cvz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 3cvz S-LAYER PROTEIN
(Clostridioides
difficile) 		4 / 6 LEU A 237
THR A   9
TYR A   8
TYR A  87
 None
None
PO4  A 274 (-4.5A)
None
 1.16A 1qvuA-3cvzA:
undetectable		 1qvuA-3cvzA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3cvz S-LAYER PROTEIN
(Clostridioides
difficile) 		5 / 12 ILE A  34
PHE A  38
GLY A  41
VAL A 247
TYR A  80
 None
 1.17A 2nyrB-3cvzA:
undetectable		 2nyrB-3cvzA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3cvz S-LAYER PROTEIN
(Clostridioides
difficile) 		5 / 12 GLY A 178
THR A 220
ALA A 188
ASP A 175
ASP A 182
 None
 0.96A 4df3A-3cvzA:
undetectable		 4df3A-3cvzA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 3cvz S-LAYER PROTEIN
(Clostridioides
difficile) 		4 / 5 VAL A 247
ASN A  39
ASP A  79
LEU A  75
 None
 1.24A 5m0iB-3cvzA:
undetectable		 5m0iB-3cvzA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 3cvz S-LAYER PROTEIN
(Clostridioides
difficile) 		5 / 12 VAL A  36
PHE A  83
ILE A  34
ASN A  69
VAL A  81
 None
 0.75A 5uvmB-3cvzA:
undetectable		 5uvmB-3cvzA:
17.54