SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cwc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 3cwc PUTATIVE GLYCERATE
KINASE 2
(Salmonella
enterica) 		6 / 12 ILE A 131
ALA A  86
GLY A  78
HIS A 120
ALA A 121
ILE A 129
 None
 1.43A 1bx4A-3cwcA:
2.9		 1bx4A-3cwcA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_1
(HIV-II PROTEASE)		 3cwc PUTATIVE GLYCERATE
KINASE 2
(Salmonella
enterica) 		6 / 12 GLY A 251
ALA A 250
VAL A 194
GLY A 246
ILE A 131
ILE A 133
 None
 1.17A 1hshA-3cwcA:
undetectable		 1hshA-3cwcA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 3cwc PUTATIVE GLYCERATE
KINASE 2
(Salmonella
enterica) 		5 / 12 LEU A 168
ALA A 225
SER A 205
GLY A 164
ILE A 166
 None
 1.22A 1kglA-3cwcA:
undetectable		 1kglA-3cwcA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 3cwc PUTATIVE GLYCERATE
KINASE 2
(Salmonella
enterica) 		6 / 12 GLY A 252
GLY A 141
LEU A 226
LEU A 168
ILE A 233
PHE A 260
 None
 1.29A 1mx1D-3cwcA:
2.6		 1mx1D-3cwcA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 3cwc PUTATIVE GLYCERATE
KINASE 2
(Salmonella
enterica) 		5 / 12 GLY A 252
GLY A 247
GLY A 246
ASP A 140
GLY A 209
 None
 0.95A 1n2xB-3cwcA:
undetectable		 1n2xB-3cwcA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 3cwc PUTATIVE GLYCERATE
KINASE 2
(Salmonella
enterica) 		4 / 7 VAL A  61
LEU A 122
ALA A  86
LEU A  79
 None
 0.89A 1pthA-3cwcA:
undetectable		 1pthA-3cwcA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 3cwc PUTATIVE GLYCERATE
KINASE 2
(Salmonella
enterica) 		5 / 12 ALA A 256
GLY A 254
ILE A 174
ASP A 236
ARG A 235
 None
 1.05A 1sqfA-3cwcA:
undetectable		 1sqfA-3cwcA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 3cwc PUTATIVE GLYCERATE
KINASE 2
(Salmonella
enterica) 		3 / 3 LEU A 237
PHE A 260
ARG A 228
 None
 0.82A 1xdkB-3cwcA:
undetectable		 1xdkB-3cwcA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3cwc PUTATIVE GLYCERATE
KINASE 2
(Salmonella
enterica) 		5 / 12 LEU A 183
LEU A 122
GLY A 115
ASP A 140
ALA A 148
 None
 1.03A 2bm9A-3cwcA:
2.0		 2bm9A-3cwcA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3cwc PUTATIVE GLYCERATE
KINASE 2
(Salmonella
enterica) 		5 / 12 LEU A 183
LEU A 122
GLY A 115
ASP A 140
ALA A 148
 None
 1.05A 2br4C-3cwcA:
undetectable		 2br4C-3cwcA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3cwc PUTATIVE GLYCERATE
KINASE 2
(Salmonella
enterica) 		5 / 12 LEU A 183
LEU A 122
GLY A 115
ASP A 140
ALA A 148
 None
 1.16A 2br4E-3cwcA:
undetectable		 2br4E-3cwcA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 3cwc PUTATIVE GLYCERATE
KINASE 2
(Salmonella
enterica) 		5 / 12 LEU A 242
GLY A 200
LEU A 244
THR A 227
ALA A 230
 None
 0.95A 2egvB-3cwcA:
2.2		 2egvB-3cwcA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 3cwc PUTATIVE GLYCERATE
KINASE 2
(Salmonella
enterica) 		5 / 12 ALA A 250
PHE A 208
GLY A 247
LEU A 242
VAL A 241
 None
 0.98A 2zifB-3cwcA:
undetectable		 2zifB-3cwcA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 3cwc PUTATIVE GLYCERATE
KINASE 2
(Salmonella
enterica) 		4 / 5 LEU A 168
ASP A 140
ILE A 174
GLY A 141
 None
 0.95A 3bufA-3cwcA:
undetectable		 3bufA-3cwcA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 3cwc PUTATIVE GLYCERATE
KINASE 2
(Salmonella
enterica) 		5 / 12 VAL A 369
ALA A 370
VAL A 362
ILE A  23
THR A 365
 None
 1.04A 3czhA-3cwcA:
undetectable		 3czhA-3cwcA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 3cwc PUTATIVE GLYCERATE
KINASE 2
(Salmonella
enterica) 		5 / 12 VAL A 369
ALA A 370
VAL A 362
ILE A  23
THR A 365
 None
 1.05A 3dl9A-3cwcA:
undetectable		 3dl9A-3cwcA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3cwc PUTATIVE GLYCERATE
KINASE 2
(Salmonella
enterica) 		4 / 7 LEU A 198
ARG A 228
SER A 136
GLY A 165
 None
 1.05A 3hcrB-3cwcA:
5.3		 3hcrB-3cwcA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_1
(FIV PROTEASE)		 3cwc PUTATIVE GLYCERATE
KINASE 2
(Salmonella
enterica) 		5 / 9 GLY A 254
ALA A 255
ILE A 233
GLY A 262
LEU A 244
 None
 0.89A 3ogpA-3cwcA:
undetectable		 3ogpA-3cwcA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_2
(FIV PROTEASE)		 3cwc PUTATIVE GLYCERATE
KINASE 2
(Salmonella
enterica) 		5 / 9 GLY A 254
ALA A 255
ILE A 233
GLY A 262
LEU A 244
 None
 0.91A 3ogpB-3cwcA:
undetectable		 3ogpB-3cwcA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_2
(PROTEASE)		 3cwc PUTATIVE GLYCERATE
KINASE 2
(Salmonella
enterica) 		6 / 12 GLY A 251
ALA A 250
VAL A 194
GLY A 246
ILE A 131
ILE A 133
 None
 1.11A 3s54B-3cwcA:
undetectable		 3s54B-3cwcA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3cwc PUTATIVE GLYCERATE
KINASE 2
(Salmonella
enterica) 		5 / 12 GLY A 251
ASP A 140
GLY A 134
SER A 136
ALA A  93
 None
 1.20A 3sueB-3cwcA:
undetectable		 3sueB-3cwcA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3cwc PUTATIVE GLYCERATE
KINASE 2
(Salmonella
enterica) 		5 / 12 LEU A 198
GLY A 142
ALA A 256
LEU A 171
ILE A 233
 None
 1.07A 4hytA-3cwcA:
undetectable		 4hytA-3cwcA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3cwc PUTATIVE GLYCERATE
KINASE 2
(Salmonella
enterica) 		5 / 12 LEU A 198
GLY A 142
ALA A 256
LEU A 171
ILE A 233
 None
 1.07A 4hytC-3cwcA:
undetectable		 4hytC-3cwcA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 3cwc PUTATIVE GLYCERATE
KINASE 2
(Salmonella
enterica) 		5 / 12 GLY A 134
GLY A  45
ALA A 191
ALA A 250
MET A  90
 None
 1.12A 4kicA-3cwcA:
undetectable		 4kicA-3cwcA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3cwc PUTATIVE GLYCERATE
KINASE 2
(Salmonella
enterica) 		5 / 12 ALA A 255
GLY A 251
GLY A 141
ILE A 219
GLY A 203
 None
 1.06A 4n48B-3cwcA:
undetectable		 4n48B-3cwcA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3cwc PUTATIVE GLYCERATE
KINASE 2
(Salmonella
enterica) 		5 / 9 ALA A  16
SER A  15
ALA A  51
ALA A  55
ALA A  20
 None
 1.27A 4twdA-3cwcA:
undetectable
4twdB-3cwcA:
undetectable
4twdC-3cwcA:
undetectable
4twdD-3cwcA:
undetectable
4twdE-3cwcA:
undetectable		 4twdA-3cwcA:
19.64
4twdB-3cwcA:
19.64
4twdC-3cwcA:
19.64
4twdD-3cwcA:
19.64
4twdE-3cwcA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 3cwc PUTATIVE GLYCERATE
KINASE 2
(Salmonella
enterica) 		3 / 3 GLU A 217
ILE A 166
ALA A 214
 None
 0.66A 4wnwB-3cwcA:
undetectable		 4wnwB-3cwcA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 3cwc PUTATIVE GLYCERATE
KINASE 2
(Salmonella
enterica) 		5 / 10 ASP A 140
ALA A 256
ILE A 174
LEU A 153
LEU A 171
 None
 1.20A 4xj7A-3cwcA:
5.4
4xj7B-3cwcA:
2.4		 4xj7A-3cwcA:
23.91
4xj7B-3cwcA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_0
(MINERALOCORTICOID
RECEPTOR)		 3cwc PUTATIVE GLYCERATE
KINASE 2
(Salmonella
enterica) 		5 / 12 LEU A 171
LEU A 153
SER A 177
LEU A 179
LEU A 237
 None
 1.19A 5mwyA-3cwcA:
undetectable		 5mwyA-3cwcA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3cwc PUTATIVE GLYCERATE
KINASE 2
(Salmonella
enterica) 		5 / 12 GLY A 248
GLU A 202
GLY A 203
GLY A 246
GLY A 247
 None
 0.87A 5zhmB-3cwcA:
undetectable		 5zhmB-3cwcA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 3cwc PUTATIVE GLYCERATE
KINASE 2
(Salmonella
enterica) 		4 / 6 SER A  15
ALA A  22
ALA A 358
SER A 359
 None
None
None
EDO  A 402 ( 3.7A)
 0.77A 6bocA-3cwcA:
undetectable
6bocB-3cwcA:
undetectable
6bocC-3cwcA:
undetectable
6bocD-3cwcA:
undetectable		 6bocA-3cwcA:
5.22
6bocB-3cwcA:
5.22
6bocC-3cwcA:
5.22
6bocD-3cwcA:
5.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 3cwc PUTATIVE GLYCERATE
KINASE 2
(Salmonella
enterica) 		4 / 6 ALA A 250
SER A 111
GLY A 115
ILE A 129
 None
 0.89A 6f8cA-3cwcA:
undetectable		 6f8cA-3cwcA:
12.07