SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cwg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)		 3cwg SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 3
(Mus
musculus) 		4 / 7 LEU A 607
THR A 622
LEU A 670
LEU A 673
 None
 0.94A 1gtiB-3cwgA:
4.5		 1gtiB-3cwgA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 3cwg SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 3
(Mus
musculus) 		4 / 7 LEU A 483
PRO A 255
VAL A 507
TRP A 510
 None
 1.38A 2hrcA-3cwgA:
undetectable		 2hrcA-3cwgA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)		 3cwg SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 3
(Mus
musculus) 		3 / 3 LYS A 557
GLY A 534
PRO A 535
 None
 0.76A 2hreB-3cwgA:
undetectable		 2hreB-3cwgA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)		 3cwg SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 3
(Mus
musculus) 		3 / 3 HIS A 332
MET A 470
MET A 329
 None
 1.38A 2vj1A-3cwgA:
undetectable		 2vj1A-3cwgA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3cwg SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 3
(Mus
musculus) 		4 / 6 TYR A 584
TYR A 686
CYH A 687
ILE A 654
 None
 1.11A 2xz5A-3cwgA:
0.0
2xz5B-3cwgA:
0.0		 2xz5A-3cwgA:
19.09
2xz5B-3cwgA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3cwg SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 3
(Mus
musculus) 		4 / 7 TYR A 584
TYR A 686
CYH A 687
ILE A 654
 None
 1.14A 2xz5B-3cwgA:
undetectable
2xz5E-3cwgA:
undetectable		 2xz5B-3cwgA:
19.09
2xz5E-3cwgA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3cwg SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 3
(Mus
musculus) 		4 / 8 ILE A 654
TYR A 584
TYR A 686
CYH A 687
 None
 1.17A 2xz5A-3cwgA:
2.1
2xz5C-3cwgA:
2.5		 2xz5A-3cwgA:
19.09
2xz5C-3cwgA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3cwg SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 3
(Mus
musculus) 		4 / 8 ILE A 654
TYR A 584
TYR A 686
CYH A 687
 None
 1.13A 2xz5C-3cwgA:
2.5
2xz5D-3cwgA:
undetectable		 2xz5C-3cwgA:
19.09
2xz5D-3cwgA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3cwg SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 3
(Mus
musculus) 		4 / 7 ILE A 654
TYR A 584
TYR A 686
CYH A 687
 None
 1.14A 2xz5D-3cwgA:
undetectable
2xz5E-3cwgA:
undetectable		 2xz5D-3cwgA:
19.09
2xz5E-3cwgA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 3cwg SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 3
(Mus
musculus) 		5 / 12 LEU A 158
LEU A 284
GLY A 223
ALA A 222
LEU A 305
 None
 1.02A 3nt1A-3cwgA:
undetectable		 3nt1A-3cwgA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 3cwg SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 3
(Mus
musculus) 		5 / 12 LEU A 158
LEU A 284
GLY A 223
ALA A 222
LEU A 305
 None
 1.03A 3nt1B-3cwgA:
undetectable		 3nt1B-3cwgA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_B_GLYB511_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3cwg SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 3
(Mus
musculus) 		4 / 5 SER A 269
GLU A 145
LEU A 148
GLN A 149
 None
 1.21A 3pgyB-3cwgA:
0.0		 3pgyB-3cwgA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 3cwg SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 3
(Mus
musculus) 		5 / 9 PHE A 345
THR A 440
VAL A 366
LEU A 413
ILE A 386
 None
 1.18A 3tbgD-3cwgA:
undetectable		 3tbgD-3cwgA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3cwg SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 3
(Mus
musculus) 		4 / 8 THR A 622
TYR A 657
ARG A 609
LEU A 608
 None
 1.09A 3wipG-3cwgA:
undetectable
3wipH-3cwgA:
2.6		 3wipG-3cwgA:
19.67
3wipH-3cwgA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3cwg SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 3
(Mus
musculus) 		4 / 8 ARG A 609
LEU A 608
THR A 622
TYR A 657
 None
 1.11A 3wipF-3cwgA:
2.7
3wipJ-3cwgA:
2.8		 3wipF-3cwgA:
19.67
3wipJ-3cwgA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 3cwg SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 3
(Mus
musculus) 		4 / 8 TRP A 580
ILE A 568
GLY A 587
ILE A 585
 None
 0.81A 3wxoA-3cwgA:
undetectable		 3wxoA-3cwgA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3cwg SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 3
(Mus
musculus) 		4 / 8 TYR A 584
TYR A 686
CYH A 687
ILE A 654
 None
 1.18A 4bqtC-3cwgA:
2.3
4bqtD-3cwgA:
2.5		 4bqtC-3cwgA:
19.09
4bqtD-3cwgA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 3cwg SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 3
(Mus
musculus) 		4 / 5 LEU A 670
GLY A 604
ILE A 634
GLN A 635
 None
 1.16A 4ma8C-3cwgA:
undetectable		 4ma8C-3cwgA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_B_ASCB304_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 3cwg SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 3
(Mus
musculus) 		4 / 6 PHE A 345
ILE A 439
PHE A 408
ASN A 390
 None
 1.16A 4o7gB-3cwgA:
3.9		 4o7gB-3cwgA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_C_CLQC1079_0
(SAPOSIN-B)		 3cwg SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 3
(Mus
musculus) 		4 / 5 ARG A 214
MET A 162
GLU A 166
LEU A 284
 None
 1.48A 4v2oA-3cwgA:
1.7
4v2oC-3cwgA:
1.4		 4v2oA-3cwgA:
8.54
4v2oC-3cwgA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3cwg SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 3
(Mus
musculus) 		4 / 7 CYH A 251
ILE A 252
GLN A 248
ILE A 258
 None
 1.04A 4w5oA-3cwgA:
undetectable		 4w5oA-3cwgA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3cwg SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 3
(Mus
musculus) 		4 / 6 CYH A 251
ILE A 252
GLN A 248
ILE A 258
 None
 1.01A 4w5qA-3cwgA:
undetectable		 4w5qA-3cwgA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3cwg SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 3
(Mus
musculus) 		4 / 6 CYH A 251
ILE A 252
GLN A 248
ILE A 258
 None
 0.94A 4w5tA-3cwgA:
undetectable		 4w5tA-3cwgA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 3cwg SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 3
(Mus
musculus) 		4 / 6 CYH A 251
ILE A 252
GLN A 248
ILE A 258
 None
 1.02A 4z4cA-3cwgA:
undetectable		 4z4cA-3cwgA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3cwg SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 3
(Mus
musculus) 		4 / 6 CYH A 251
ILE A 252
GLN A 248
ILE A 258
 None
 1.03A 4z4dA-3cwgA:
undetectable		 4z4dA-3cwgA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3cwg SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 3
(Mus
musculus) 		4 / 7 CYH A 251
ILE A 252
GLN A 248
ILE A 258
 None
 0.99A 4z4eA-3cwgA:
undetectable		 4z4eA-3cwgA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3cwg SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 3
(Mus
musculus) 		4 / 7 CYH A 251
ILE A 252
GLN A 248
ILE A 258
 None
 1.05A 4z4gA-3cwgA:
undetectable		 4z4gA-3cwgA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3cwg SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 3
(Mus
musculus) 		4 / 5 GLU A 442
THR A 456
HIS A 410
LEU A 411
 None
 1.23A 5axaA-3cwgA:
undetectable		 5axaA-3cwgA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 3cwg SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 3
(Mus
musculus) 		4 / 8 HIS A 147
LEU A 148
LEU A 144
THR A 138
 None
 1.02A 5hs6A-3cwgA:
undetectable		 5hs6A-3cwgA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 3cwg SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 3
(Mus
musculus) 		4 / 7 VAL A 490
ARG A 382
GLU A 435
LEU A 413
 None
 1.14A 5umwB-3cwgA:
undetectable
5umwE-3cwgA:
undetectable		 5umwB-3cwgA:
8.54
5umwE-3cwgA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 3cwg SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 3
(Mus
musculus) 		4 / 6 CYH A 251
ILE A 252
GLN A 248
ILE A 258
 None
 0.95A 6cbdA-3cwgA:
undetectable		 6cbdA-3cwgA:
21.44