SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cwq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 3cwq PARA FAMILY
CHROMOSOME
PARTITIONING PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLU A 194
GLY A 156
PHE A 153
TYR A 160
ALA A 184
 None
 1.14A 1hvyA-3cwqA:
undetectable		 1hvyA-3cwqA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 3cwq PARA FAMILY
CHROMOSOME
PARTITIONING PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLU A 194
GLY A 156
PHE A 153
TYR A 160
ALA A 184
 None
 1.12A 1hvyB-3cwqA:
undetectable		 1hvyB-3cwqA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 3cwq PARA FAMILY
CHROMOSOME
PARTITIONING PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 6 GLU A 113
ALA A 148
LEU A 145
THR A 147
 None
 0.90A 2roxB-3cwqA:
undetectable		 2roxB-3cwqA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 3cwq PARA FAMILY
CHROMOSOME
PARTITIONING PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 10 ASP A  92
CYH A  91
GLY A  90
ALA A  88
ALA A  86
 None
 1.21A 3ucjB-3cwqA:
undetectable		 3ucjB-3cwqA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 3cwq PARA FAMILY
CHROMOSOME
PARTITIONING PROTEIN
(Synechocystis
sp.
PCC
6803) 		3 / 3 SER A  41
GLU A  58
GLU A  80
 ADP  A 301 ( 4.3A)
None
None
 0.76A 4ymgB-3cwqA:
undetectable		 4ymgB-3cwqA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 3cwq PARA FAMILY
CHROMOSOME
PARTITIONING PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLU A 198
LEU A 108
THR A 111
GLY A 119
LEU A 118
 None
 1.35A 5m50E-3cwqA:
5.7		 5m50E-3cwqA:
19.91