SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cwr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_2
(TRANSTHYRETIN)		 3cwr TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Rhodospirillum
rubrum) 		4 / 7 LEU A 174
ALA A 106
LEU A 102
VAL A  68
 None
 1.02A 1dvxB-3cwrA:
undetectable		 1dvxB-3cwrA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3cwr TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Rhodospirillum
rubrum) 		4 / 8 ALA A 162
ASP A  96
ILE A  97
ILE A  72
 None
 0.88A 1p7lD-3cwrA:
undetectable		 1p7lD-3cwrA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3cwr TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Rhodospirillum
rubrum) 		4 / 8 ALA A 162
ASP A  96
ILE A  97
ILE A  72
 None
 0.88A 1p7lC-3cwrA:
undetectable		 1p7lC-3cwrA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3cwr TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Rhodospirillum
rubrum) 		4 / 8 ALA A 162
ASP A  96
ILE A  97
ILE A  72
 None
 0.88A 1rg9B-3cwrA:
undetectable		 1rg9B-3cwrA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3cwr TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Rhodospirillum
rubrum) 		4 / 8 ALA A 162
ASP A  96
ILE A  97
ILE A  72
 None
 0.87A 1rg9A-3cwrA:
undetectable		 1rg9A-3cwrA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3cwr TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Rhodospirillum
rubrum) 		4 / 8 ALA A 162
ASP A  96
ILE A  97
ILE A  72
 None
 0.87A 1rg9D-3cwrA:
undetectable		 1rg9D-3cwrA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3cwr TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Rhodospirillum
rubrum) 		4 / 8 ALA A 162
ASP A  96
ILE A  97
ILE A  72
 None
 0.88A 1rg9C-3cwrA:
undetectable		 1rg9C-3cwrA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 3cwr TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Rhodospirillum
rubrum) 		4 / 6 LEU A 174
ALA A 106
LEU A 102
VAL A  68
 None
 1.01A 1sn5A-3cwrA:
undetectable		 1sn5A-3cwrA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 3cwr TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Rhodospirillum
rubrum) 		4 / 8 LEU A 174
ALA A 106
LEU A 102
VAL A  68
 None
 0.98A 1sn5C-3cwrA:
undetectable		 1sn5C-3cwrA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 3cwr TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Rhodospirillum
rubrum) 		4 / 7 GLY A  33
GLY A  32
ALA A  35
ALA A  36
 None
 0.67A 2ha4B-3cwrA:
undetectable		 2ha4B-3cwrA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3cwr TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Rhodospirillum
rubrum) 		5 / 12 ASN A 130
GLY A  65
ASP A  62
LEU A  29
MET A 112
 None
 1.10A 2zw9A-3cwrA:
undetectable		 2zw9A-3cwrA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_A_1FLA502_1
(TRANSTHYRETIN)		 3cwr TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Rhodospirillum
rubrum) 		4 / 7 LEU A 174
ALA A 106
LEU A 102
VAL A  68
 None
 1.00A 3d2tA-3cwrA:
undetectable		 3d2tA-3cwrA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 3cwr TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Rhodospirillum
rubrum) 		4 / 7 LEU A 174
ALA A 106
LEU A 102
VAL A  68
 None
 0.99A 3ozkB-3cwrA:
undetectable		 3ozkB-3cwrA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3cwr TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Rhodospirillum
rubrum) 		4 / 8 ALA A 162
ASP A  96
ILE A  97
ILE A  72
 None
 0.80A 4kttB-3cwrA:
undetectable		 4kttB-3cwrA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3cwr TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Rhodospirillum
rubrum) 		4 / 8 ALA A 162
ASP A  96
ILE A  97
ILE A  72
 None
 0.81A 4kttD-3cwrA:
undetectable		 4kttD-3cwrA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3cwr TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Rhodospirillum
rubrum) 		4 / 8 ALA A 162
ASP A  96
ILE A  97
ILE A  72
 None
 0.82A 4ndnB-3cwrA:
undetectable		 4ndnB-3cwrA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3cwr TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Rhodospirillum
rubrum) 		4 / 8 ALA A 162
ASP A  96
ILE A  97
ILE A  72
 None
 0.83A 4ndnD-3cwrA:
undetectable		 4ndnD-3cwrA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 3cwr TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Rhodospirillum
rubrum) 		4 / 6 LEU A 174
ALA A 106
LEU A 102
VAL A  68
 None
 0.99A 5a6iA-3cwrA:
undetectable		 5a6iA-3cwrA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)		 3cwr TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Rhodospirillum
rubrum) 		4 / 5 LEU A 174
ALA A 106
LEU A 102
VAL A  68
 None
 1.07A 5cr1A-3cwrA:
undetectable		 5cr1A-3cwrA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3cwr TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Rhodospirillum
rubrum) 		4 / 8 ALA A 162
ASP A  96
ILE A  97
ILE A  72
 None
 0.86A 5t8sA-3cwrA:
undetectable		 5t8sA-3cwrA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3cwr TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Rhodospirillum
rubrum) 		3 / 3 GLY A  65
VAL A  42
MET A  37
 None
 0.55A 5ycpA-3cwrA:
undetectable		 5ycpA-3cwrA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 3cwr TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Rhodospirillum
rubrum) 		4 / 8 LEU A 109
LEU A 113
LEU A  63
GLY A  59
 None
 0.86A 6ce2A-3cwrA:
undetectable		 6ce2A-3cwrA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3cwr TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Rhodospirillum
rubrum) 		4 / 7 ALA A 162
ASP A  96
ILE A  97
ILE A  72
 None
 0.81A 6fbnA-3cwrA:
undetectable		 6fbnA-3cwrA:
20.55