SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cwu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 3cwu DNA-3-METHYLADENINE
GLYCOSYLASE 2
(Escherichia
coli) 		4 / 6 SER A  26
ILE A 153
ALA A 139
ALA A 132
 None
 0.97A 1w0gA-3cwuA:
undetectable		 1w0gA-3cwuA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 3cwu DNA-3-METHYLADENINE
GLYCOSYLASE 2
(Escherichia
coli) 		4 / 8 THR A 211
GLY A 216
THR A 219
ALA A 220
 None
 0.86A 2a1hA-3cwuA:
undetectable
2a1hB-3cwuA:
undetectable		 2a1hA-3cwuA:
22.60
2a1hB-3cwuA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7L_A_TESA155_1
(ANDROGEN RECEPTOR)		 3cwu DNA-3-METHYLADENINE
GLYCOSYLASE 2
(Escherichia
coli) 		5 / 12 LEU A 182
LEU A 185
GLY A 117
MET A 174
THR A 135
 None
 1.44A 2q7lA-3cwuA:
undetectable		 2q7lA-3cwuA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 3cwu DNA-3-METHYLADENINE
GLYCOSYLASE 2
(Escherichia
coli) 		4 / 6 LEU A 240
ASP A 238
TRP A 272
ILE A 271
 None
 1.14A 2rlfB-3cwuA:
undetectable
2rlfC-3cwuA:
undetectable		 2rlfB-3cwuA:
11.17
2rlfC-3cwuA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3cwu DNA-3-METHYLADENINE
GLYCOSYLASE 2
(Escherichia
coli) 		5 / 12 GLY A 117
ALA A 220
THR A 219
ALA A 205
ALA A 189
 None
 1.08A 3g89A-3cwuA:
undetectable		 3g89A-3cwuA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3cwu DNA-3-METHYLADENINE
GLYCOSYLASE 2
(Escherichia
coli) 		5 / 11 GLY A 117
ALA A 220
THR A 219
ALA A 205
ALA A 189
 None
 1.08A 3g89B-3cwuA:
undetectable		 3g89B-3cwuA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3cwu DNA-3-METHYLADENINE
GLYCOSYLASE 2
(Escherichia
coli) 		5 / 12 GLY A 117
ALA A 220
THR A 219
ALA A 205
ALA A 189
 None
 1.09A 3g8bA-3cwuA:
undetectable		 3g8bA-3cwuA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3cwu DNA-3-METHYLADENINE
GLYCOSYLASE 2
(Escherichia
coli) 		5 / 12 GLY A 117
ALA A 220
THR A 219
ALA A 205
ALA A 189
 None
 1.05A 3g8bB-3cwuA:
undetectable		 3g8bB-3cwuA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		 3cwu DNA-3-METHYLADENINE
GLYCOSYLASE 2
(Escherichia
coli) 		5 / 12 GLY A 123
GLN A 124
VAL A 126
MET A 174
LEU A 169
 None
 1.16A 3h52A-3cwuA:
undetectable		 3h52A-3cwuA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ITA_D_AICD501_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC)		 3cwu DNA-3-METHYLADENINE
GLYCOSYLASE 2
(Escherichia
coli) 		3 / 3 PRO A 236
PHE A 245
ALA A 257
 None
 0.71A 3itaD-3cwuA:
undetectable		 3itaD-3cwuA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3cwu DNA-3-METHYLADENINE
GLYCOSYLASE 2
(Escherichia
coli) 		5 / 12 ARG A  22
ALA A 136
ALA A 132
ALA A 131
SER A 127
 None
 1.04A 3sudA-3cwuA:
undetectable		 3sudA-3cwuA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_2
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 3cwu DNA-3-METHYLADENINE
GLYCOSYLASE 2
(Escherichia
coli) 		4 / 5 PHE A  18
HIS A 270
LEU A 268
PRO A 108
 None
 1.49A 5csyB-3cwuA:
undetectable		 5csyB-3cwuA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 3cwu DNA-3-METHYLADENINE
GLYCOSYLASE 2
(Escherichia
coli) 		5 / 12 ASP A 201
LEU A 235
LEU A 225
ALA A 230
ARG A 217
 None
 1.19A 5nd7B-3cwuA:
undetectable		 5nd7B-3cwuA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 3cwu DNA-3-METHYLADENINE
GLYCOSYLASE 2
(Escherichia
coli) 		4 / 7 ARG A  37
TYR A  35
GLU A  28
ARG A 226
 None
 0.91A 5umwB-3cwuA:
undetectable
5umwE-3cwuA:
undetectable		 5umwB-3cwuA:
13.12
5umwE-3cwuA:
13.12