SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cx3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_C_CHDC1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3cx3 LIPOPROTEIN
(Streptococcus
pneumoniae) 		4 / 5 PHE A 195
PHE A 199
LEU A 223
PHE A 207
 None
 1.36A 2y69C-3cx3A:
undetectable
2y69J-3cx3A:
undetectable		 2y69C-3cx3A:
20.00
2y69J-3cx3A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_C_CTCC1385_0
(TETX2 PROTEIN)		 3cx3 LIPOPROTEIN
(Streptococcus
pneumoniae) 		5 / 12 ASP A 145
ASN A 262
GLY A  69
SER A 287
PRO A 284
 None
 1.32A 2y6rC-3cx3A:
3.1		 2y6rC-3cx3A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3cx3 LIPOPROTEIN
(Streptococcus
pneumoniae) 		4 / 5 PHE A 195
PHE A 199
LEU A 223
PHE A 207
 None
 1.37A 3abmC-3cx3A:
undetectable
3abmJ-3cx3A:
undetectable		 3abmC-3cx3A:
20.00
3abmJ-3cx3A:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3cx3 LIPOPROTEIN
(Streptococcus
pneumoniae) 		4 / 5 PHE A 195
PHE A 199
LEU A 223
PHE A 207
 None
 1.34A 3ag3C-3cx3A:
undetectable
3ag3J-3cx3A:
undetectable		 3ag3C-3cx3A:
20.00
3ag3J-3cx3A:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)		 3cx3 LIPOPROTEIN
(Streptococcus
pneumoniae) 		4 / 5 ILE A  47
PRO A  46
TYR A  45
TYR A  48
 None
 1.26A 3d9lA-3cx3A:
1.0
3d9lY-3cx3A:
undetectable		 3d9lA-3cx3A:
18.25
3d9lY-3cx3A:
4.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 3cx3 LIPOPROTEIN
(Streptococcus
pneumoniae) 		5 / 12 GLY A 227
PRO A 237
PHE A 258
THR A 270
LEU A 271
 None
 1.06A 3mteB-3cx3A:
undetectable		 3mteB-3cx3A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 3cx3 LIPOPROTEIN
(Streptococcus
pneumoniae) 		5 / 12 GLY A 227
PRO A 237
PHE A 258
THR A 270
LEU A 271
 None
 1.04A 3p2kA-3cx3A:
undetectable		 3p2kA-3cx3A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA602_0
(LACCASE-1)		 3cx3 LIPOPROTEIN
(Streptococcus
pneumoniae) 		3 / 3 HIS A 147
HIS A  71
HIS A 211
 ZN  A 314 (-3.2A)
ZN  A 314 (-3.1A)
ZN  A 314 (-3.3A)
 0.39A 3qpkA-3cx3A:
undetectable		 3qpkA-3cx3A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB602_0
(LACCASE-1)		 3cx3 LIPOPROTEIN
(Streptococcus
pneumoniae) 		3 / 3 HIS A 147
HIS A  71
HIS A 211
 ZN  A 314 (-3.2A)
ZN  A 314 (-3.1A)
ZN  A 314 (-3.3A)
 0.38A 3qpkB-3cx3A:
undetectable		 3qpkB-3cx3A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_2
(POL POLYPROTEIN)		 3cx3 LIPOPROTEIN
(Streptococcus
pneumoniae) 		5 / 9 ASP A 288
GLY A  69
ILE A  70
PRO A 284
LEU A 285
 None
 1.23A 3u7sB-3cx3A:
undetectable		 3u7sB-3cx3A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		 3cx3 LIPOPROTEIN
(Streptococcus
pneumoniae) 		5 / 11 ASP A 145
ASN A 262
GLY A  69
SER A 287
PRO A 284
 None
 1.29A 3v3oC-3cx3A:
undetectable		 3v3oC-3cx3A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 3cx3 LIPOPROTEIN
(Streptococcus
pneumoniae) 		4 / 6 ASP A  79
ASN A  78
ALA A  81
TYR A  84
 None
 1.12A 4mdaA-3cx3A:
undetectable		 4mdaA-3cx3A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 3cx3 LIPOPROTEIN
(Streptococcus
pneumoniae) 		3 / 3 SER A  67
GLU A 260
GLU A 269
 None
 0.86A 4ymgB-3cx3A:
undetectable		 4ymgB-3cx3A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA601_0
(LACCASE 2)		 3cx3 LIPOPROTEIN
(Streptococcus
pneumoniae) 		3 / 3 HIS A 147
HIS A  71
HIS A 211
 ZN  A 314 (-3.2A)
ZN  A 314 (-3.1A)
ZN  A 314 (-3.3A)
 0.39A 5migA-3cx3A:
undetectable		 5migA-3cx3A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 3cx3 LIPOPROTEIN
(Streptococcus
pneumoniae) 		5 / 11 GLU A 234
SER A 265
ALA A 268
THR A 259
THR A 281
 None
 1.45A 6efnA-3cx3A:
undetectable		 6efnA-3cx3A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)		 3cx3 LIPOPROTEIN
(Streptococcus
pneumoniae) 		3 / 3 LEU A 217
SER A 215
PHE A 214
 None
 0.56A 6fgcA-3cx3A:
undetectable		 6fgcA-3cx3A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 3cx3 LIPOPROTEIN
(Streptococcus
pneumoniae) 		4 / 6 PRO A 146
HIS A 147
HIS A 211
GLU A 286
 None
ZN  A 314 (-3.2A)
ZN  A 314 (-3.3A)
ZN  A 314 (-2.4A)
 1.04A 6pahA-3cx3A:
undetectable		 6pahA-3cx3A:
20.54