SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cx6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT
(Mus
musculus) 		4 / 8 SER A  59
SER A  62
GLY A 225
GLY A  55
 GDP  A 775 (-3.4A)
MG  A 675 ( 2.7A)
None
None
 0.70A 1aq7A-3cx6A:
undetectable		 1aq7A-3cx6A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT
(Mus
musculus) 		5 / 8 SER A 268
SER A 248
VAL A 247
GLY A  57
GLY A  55
 None
None
None
GDP  A 775 ( 4.2A)
None
 1.24A 1aq7A-3cx6A:
undetectable		 1aq7A-3cx6A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT
(Mus
musculus) 		4 / 8 SER A  59
SER A  62
GLY A 225
GLY A  55
 GDP  A 775 (-3.4A)
MG  A 675 ( 2.7A)
None
None
 0.67A 1f5lA-3cx6A:
undetectable		 1f5lA-3cx6A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)		 3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT
(Mus
musculus) 		4 / 6 ASP A 179
ASN A 180
TRP A 153
TYR A 162
 None
 1.49A 1hpkA-3cx6A:
undetectable		 1hpkA-3cx6A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7G_A_BCZA801_0
(NEURAMINIDASE)		 3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT
(Mus
musculus) 		5 / 12 ARG A 230
TRP A 233
ILE A 271
GLU A 251
ARG A 264
 None
 1.29A 1l7gA-3cx6A:
undetectable		 1l7gA-3cx6A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT
(Mus
musculus) 		5 / 12 ILE A 355
LEU A 246
PHE A  64
SER A 242
ILE A  51
 None
 1.26A 1rh3A-3cx6A:
undetectable		 1rh3A-3cx6A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TNL_A_TPAA900_1
(TRYPSIN)		 3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT
(Mus
musculus) 		4 / 6 SER A  59
SER A  62
GLY A 225
GLY A  55
 GDP  A 775 (-3.4A)
MG  A 675 ( 2.7A)
None
None
 0.75A 1tnlA-3cx6A:
undetectable		 1tnlA-3cx6A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TNL_A_TPAA900_1
(TRYPSIN)		 3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT
(Mus
musculus) 		5 / 6 SER A 268
SER A 248
VAL A 247
GLY A  57
GLY A  55
 None
None
None
GDP  A 775 ( 4.2A)
None
 1.19A 1tnlA-3cx6A:
undetectable		 1tnlA-3cx6A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT
(Mus
musculus) 		3 / 3 GLU A 229
GLU A 235
LEU A  52
 None
 0.73A 1v8bA-3cx6A:
undetectable		 1v8bA-3cx6A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT
(Mus
musculus) 		4 / 6 LEU A 170
GLY A  95
LEU A 178
ILE A 158
 None
 0.84A 1yajF-3cx6A:
undetectable		 1yajF-3cx6A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT
(Mus
musculus) 		4 / 7 GLY A 225
SER A  59
ARG A 230
GLU A 251
 None
GDP  A 775 (-3.4A)
None
None
 1.06A 2c8aB-3cx6A:
undetectable		 2c8aB-3cx6A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HTU_A_BCZA801_0
(NEURAMINIDASE)		 3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT
(Mus
musculus) 		5 / 12 ARG A 230
TRP A 233
ILE A 271
GLU A 251
ARG A 264
 None
 1.33A 2htuA-3cx6A:
undetectable		 2htuA-3cx6A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT
(Mus
musculus) 		4 / 7 ASP A 369
THR A 241
ILE A  51
PHE A 218
 None
 1.19A 2jc9A-3cx6A:
undetectable		 2jc9A-3cx6A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT
(Mus
musculus) 		4 / 6 SER A  59
SER A  62
GLY A 225
GLY A  55
 GDP  A 775 (-3.4A)
MG  A 675 ( 2.7A)
None
None
 0.74A 2otvA-3cx6A:
undetectable		 2otvA-3cx6A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT
(Mus
musculus) 		5 / 6 SER A 268
SER A 248
VAL A 247
GLY A  57
GLY A  55
 None
None
None
GDP  A 775 ( 4.2A)
None
 1.18A 2otvA-3cx6A:
undetectable		 2otvA-3cx6A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT
(Mus
musculus) 		4 / 8 SER A  59
SER A  62
GLY A 225
GLY A  55
 GDP  A 775 (-3.4A)
MG  A 675 ( 2.7A)
None
None
 0.70A 2vinA-3cx6A:
undetectable		 2vinA-3cx6A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT
(Mus
musculus) 		5 / 8 SER A 268
SER A 248
VAL A 247
GLY A  57
GLY A  55
 None
None
None
GDP  A 775 ( 4.2A)
None
 1.21A 2vinA-3cx6A:
undetectable		 2vinA-3cx6A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT
(Mus
musculus) 		4 / 6 HIS A 345
THR A 347
PHE A 346
LEU A 288
 None
 1.15A 3bgdA-3cx6A:
undetectable		 3bgdA-3cx6A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT202_1
(PROTEIN S100-A4)		 3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT
(Mus
musculus) 		5 / 11 PHE A 245
GLU A 251
LEU A 265
SER A 268
PHE A 289
 None
 1.30A 3ko0Q-3cx6A:
undetectable
3ko0R-3cx6A:
undetectable
3ko0S-3cx6A:
undetectable
3ko0T-3cx6A:
undetectable		 3ko0Q-3cx6A:
15.02
3ko0R-3cx6A:
15.02
3ko0S-3cx6A:
15.02
3ko0T-3cx6A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT
(Mus
musculus) 		5 / 12 ALA A 349
PHE A 289
LEU A 246
ILE A  51
SER A 242
 GDP  A 775 (-3.2A)
None
None
None
None
 1.13A 3nrrA-3cx6A:
undetectable		 3nrrA-3cx6A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT
(Mus
musculus) 		5 / 12 ALA A 349
PHE A 289
LEU A 246
ILE A  51
SER A 242
 GDP  A 775 (-3.2A)
None
None
None
None
 1.09A 3nrrB-3cx6A:
undetectable		 3nrrB-3cx6A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT
(Mus
musculus) 		4 / 6 SER A  59
SER A  62
GLY A 225
GLY A  55
 GDP  A 775 (-3.4A)
MG  A 675 ( 2.7A)
None
None
 0.62A 3rxfA-3cx6A:
undetectable		 3rxfA-3cx6A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT
(Mus
musculus) 		5 / 6 SER A 268
SER A 248
VAL A 247
GLY A  57
GLY A  55
 None
None
None
GDP  A 775 ( 4.2A)
None
 1.21A 3rxfA-3cx6A:
undetectable		 3rxfA-3cx6A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_0
(NEURAMINIDASE)		 3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT
(Mus
musculus) 		5 / 12 ARG A 230
TRP A 233
ILE A 271
GLU A 251
ARG A 264
 None
 1.30A 4mwvA-3cx6A:
undetectable		 4mwvA-3cx6A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT
(Mus
musculus) 		3 / 3 ARG A 230
TRP A 233
ILE A 271
 None
 0.88A 4mwxA-3cx6A:
undetectable		 4mwxA-3cx6A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT
(Mus
musculus) 		6 / 12 GLY A  60
GLY A  57
GLY A 225
SER A  59
ALA A 349
THR A 348
 GDP  A 775 (-3.2A)
GDP  A 775 ( 4.2A)
None
GDP  A 775 (-3.4A)
GDP  A 775 (-3.2A)
GDP  A 775 (-3.8A)
 1.43A 4uckA-3cx6A:
undetectable		 4uckA-3cx6A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT
(Mus
musculus) 		3 / 3 THR A  87
ALA A 199
ASN A  91
 None
 0.58A 5ersA-3cx6A:
3.3		 5ersA-3cx6A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT
(Mus
musculus) 		3 / 3 THR A 127
PRO A 202
ARG A 201
 None
 0.88A 5nd7B-3cx6A:
2.0		 5nd7B-3cx6A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT
(Mus
musculus) 		4 / 9 HIS A 207
ASP A 222
VAL A 247
SER A 248
 None
MG  A 675 (-2.7A)
None
None
 0.97A 6c2mD-3cx6A:
undetectable		 6c2mD-3cx6A:
12.87