SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cxl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 3cxl N-CHIMERIN
(Homo
sapiens) 		5 / 9 LEU A 397
VAL A 448
VAL A 421
GLY A 419
LEU A 394
 None
 1.41A 1lwfA-3cxlA:
undetectable		 1lwfA-3cxlA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 3cxl N-CHIMERIN
(Homo
sapiens) 		5 / 12 LEU A 343
THR A 279
VAL A 274
LEU A 270
LEU A 397
 None
 1.25A 1mx1C-3cxlA:
undetectable		 1mx1C-3cxlA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3cxl N-CHIMERIN
(Homo
sapiens) 		5 / 12 LEU A 229
THR A 212
ASP A 119
THR A 123
GLY A 233
 None
 1.46A 1v8bA-3cxlA:
undetectable		 1v8bA-3cxlA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3cxl N-CHIMERIN
(Homo
sapiens) 		5 / 12 LEU A 229
THR A 212
ASP A 119
THR A 123
GLY A 233
 None
 1.46A 1v8bB-3cxlA:
undetectable		 1v8bB-3cxlA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_D_ADND3502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3cxl N-CHIMERIN
(Homo
sapiens) 		5 / 12 LEU A 229
THR A 212
ASP A 119
THR A 123
GLY A 233
 None
 1.42A 1v8bD-3cxlA:
undetectable		 1v8bD-3cxlA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 3cxl N-CHIMERIN
(Homo
sapiens) 		5 / 12 LEU A 426
LEU A 397
MET A 398
LEU A 302
VAL A 404
 None
 1.10A 2hrcB-3cxlA:
undetectable		 2hrcB-3cxlA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 3cxl N-CHIMERIN
(Homo
sapiens) 		5 / 12 TYR A 266
ALA A 342
VAL A 315
MET A 287
HIS A 277
 None
 1.07A 2qo4A-3cxlA:
undetectable		 2qo4A-3cxlA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 3cxl N-CHIMERIN
(Homo
sapiens) 		5 / 12 ILE A 122
GLY A 120
VAL A 105
GLY A 228
THR A 118
 None
 0.97A 3bwcA-3cxlA:
undetectable		 3bwcA-3cxlA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3cxl N-CHIMERIN
(Homo
sapiens) 		4 / 6 GLU A 291
ILE A 292
GLU A 410
HIS A 407
 None
 1.09A 4ejwB-3cxlA:
undetectable		 4ejwB-3cxlA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 3cxl N-CHIMERIN
(Homo
sapiens) 		3 / 3 PHE A 208
VAL A 243
GLU A 220
 None
 0.83A 4fvqA-3cxlA:
undetectable		 4fvqA-3cxlA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA505_0
(RNA POLYMERASE
3D-POL)		 3cxl N-CHIMERIN
(Homo
sapiens) 		3 / 3 CYH A 268
ASN A 242
LYS A 264
 None
 1.45A 4k50A-3cxlA:
undetectable		 4k50A-3cxlA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 3cxl N-CHIMERIN
(Homo
sapiens) 		5 / 12 VAL A 404
LEU A 394
PHE A 422
ARG A 281
LEU A 343
 None
 1.12A 5nd7B-3cxlA:
undetectable		 5nd7B-3cxlA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3cxl N-CHIMERIN
(Homo
sapiens) 		5 / 12 THR A 356
ILE A 352
LEU A 401
PHE A 347
LEU A 343
 None
 1.12A 6a93A-3cxlA:
undetectable		 6a93A-3cxlA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 3cxl N-CHIMERIN
(Homo
sapiens) 		5 / 12 VAL A 404
LEU A 394
PHE A 422
LEU A 426
LEU A 343
 None
 1.12A 6ew0G-3cxlA:
undetectable		 6ew0G-3cxlA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_1
(-)		 3cxl N-CHIMERIN
(Homo
sapiens) 		5 / 10 GLY A 296
LEU A 297
TYR A 303
SER A 306
HIS A 407
 None
 1.23A 6gnfC-3cxlA:
undetectable		 6gnfC-3cxlA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA204_0
(N-ACETYLTRANSFERASE)		 3cxl N-CHIMERIN
(Homo
sapiens) 		4 / 5 LEU A 229
THR A 118
THR A 123
GLY A 120
 None
 1.07A 6gtqA-3cxlA:
undetectable		 6gtqA-3cxlA:
17.10