SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cxp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ICT_C_T44C128_1 (TRANSTHYRETIN)	3cxp	GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE (Homo sapiens)	5 / 11	LEU A 41 ALA A 101 LEU A 103 THR A 87 VAL A 89	None	1.02A	1ictA-3cxpA: undetectable 1ictC-3cxpA: undetectable	1ictA-3cxpA: 24.00 1ictC-3cxpA: 24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GGU_B_017B201_1 (PROTEASE)	3cxp	GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE (Homo sapiens)	5 / 12	LEU A 41 GLY A 36 VAL A 98 GLY A 130 VAL A 89	None	1.04A	3gguA-3cxpA: undetectable	3gguA-3cxpA: 20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LTW_A_HLZA300_1 (ARYLAMINE N-ACETYLTRANSFERASE NAT)	3cxp	GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE (Homo sapiens)	4 / 6	PHE A 168 TYR A 165 VAL A 124 PHE A 164	None	1.33A	3ltwA-3cxpA: undetectable	3ltwA-3cxpA: 21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3P73_A_ACTA275_0 (MHC RFP-Y CLASS I ALPHA CHAIN)	3cxp	GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE (Homo sapiens)	3 / 3	ILE A 97 VAL A 88 ARG A 42	None	0.73A	3p73A-3cxpA: undetectable	3p73A-3cxpA: 21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QD3_A_5AEA201_1 (PEPTIDYL-TRNA HYDROLASE)	3cxp	GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE (Homo sapiens)	5 / 9	LEU A 133 GLY A 130 VAL A 124 SER A 125 VAL A 98	None	1.13A	4qd3A-3cxpA: undetectable	4qd3A-3cxpA: 20.19

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1ICT_C_T44C128_1","TRANSTHYRETIN;TRANSTHYRETIN","3cxp","GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE","Homo sapiens",5,"LEU A  41;ALA A 101;LEU A 103;THR A  87;VAL A  89","None","1.02A","1ictA-3cxpA:undetectable;1ictC-3cxpA:undetectable","1ictA-3cxpA:24.00;1ictC-3cxpA:24.00"],["3GGU_B_017B201_1","PROTEASE;PROTEASE","3cxp","GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE","Homo sapiens",5,"LEU A  41;GLY A  36;VAL A  98;GLY A 130;VAL A  89","None","1.04A","3gguA-3cxpA:undetectable","3gguA-3cxpA:20.65"],["3LTW_A_HLZA300_1","ARYLAMINE N-ACETYLTRANSFERASE NAT","3cxp","GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE","Homo sapiens",4,"PHE A 168;TYR A 165;VAL A 124;PHE A 164","None","1.33A","3ltwA-3cxpA:undetectable","3ltwA-3cxpA:21.43"],["3P73_A_ACTA275_0","MHC RFP-Y CLASS I ALPHA CHAIN","3cxp","GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE","Homo sapiens",3,"ILE A  97;VAL A  88;ARG A  42","None","0.73A","3p73A-3cxpA:undetectable","3p73A-3cxpA:21.05"],["4QD3_A_5AEA201_1","PEPTIDYL-TRNA HYDROLASE","3cxp","GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE","Homo sapiens",5,"LEU A 133;GLY A 130;VAL A 124;SER A 125;VAL A  98","None","1.13A","4qd3A-3cxpA:undetectable","4qd3A-3cxpA:20.19"]]