SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cy5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IWH_A_PEMA501_1
(HEMOGLOBIN ALPHA
CHAIN)		 3cy5 HEMOGLOBIN SUBUNIT
BETA
(Bubalus
bubalis) 		5 / 6 ALA B  62
LYS B  65
LYS B  66
ASP B  69
LEU B  88
 None
None
HEM  B 147 (-3.2A)
None
HEM  B 147 (-4.2A)
 0.93A 1iwhA-3cy5B:
22.2		 1iwhA-3cy5B:
43.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 3cy5 HEMOGLOBIN SUBUNIT
BETA
(Bubalus
bubalis) 		4 / 7 PHE B  42
PHE B  45
VAL B  67
HIS B  92
 HEM  B 147 (-4.0A)
None
HEM  B 147 ( 3.8A)
HEM  B 147 (-3.3A)
 0.80A 1lh6A-3cy5B:
13.2		 1lh6A-3cy5B:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 3cy5 HEMOGLOBIN SUBUNIT
BETA
(Bubalus
bubalis) 		5 / 11 LEU B  68
GLY B  24
GLY B  25
LEU B 110
HIS B 117
 None
 1.15A 1mx1A-3cy5B:
undetectable		 1mx1A-3cy5B:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 3cy5 HEMOGLOBIN SUBUNIT
BETA
(Bubalus
bubalis) 		4 / 5 PHE B 122
LEU B 110
VAL B 134
VAL B  11
 None
 1.16A 1t88B-3cy5B:
undetectable		 1t88B-3cy5B:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3cy5 HEMOGLOBIN SUBUNIT
BETA
(Bubalus
bubalis) 		5 / 9 LEU B  68
LEU B 110
VAL B 137
ALA B 140
LEU B  88
 None
None
None
None
HEM  B 147 (-4.2A)
 1.19A 1tbfA-3cy5B:
undetectable		 1tbfA-3cy5B:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 3cy5 HEMOGLOBIN SUBUNIT
BETA
(Bubalus
bubalis) 		4 / 6 LEU B  81
HIS B  77
ASN B  73
PHE B  71
 None
None
None
HEM  B 147 ( 4.6A)
 0.67A 1xf1B-3cy5B:
undetectable		 1xf1B-3cy5B:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M56_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3cy5 HEMOGLOBIN SUBUNIT
BETA
(Bubalus
bubalis) 		4 / 5 PHE B 122
LEU B 110
VAL B 134
VAL B  11
 None
 1.22A 2m56A-3cy5B:
undetectable		 2m56A-3cy5B:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3cy5 HEMOGLOBIN SUBUNIT
BETA
(Bubalus
bubalis) 		4 / 6 PHE B 122
LEU B 110
VAL B 134
VAL B  11
 None
 1.13A 4g3rA-3cy5B:
undetectable		 4g3rA-3cy5B:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L49_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3cy5 HEMOGLOBIN SUBUNIT
BETA
(Bubalus
bubalis) 		4 / 5 PHE B 122
LEU B 110
VAL B 134
VAL B  11
 None
 1.15A 4l49A-3cy5B:
undetectable		 4l49A-3cy5B:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 3cy5 HEMOGLOBIN SUBUNIT
BETA
(Bubalus
bubalis) 		4 / 6 VAL B 113
HIS B 117
LEU B 114
LEU B  68
 None
 1.21A 5hrqB-3cy5B:
undetectable
5hrqI-3cy5B:
undetectable
5hrqJ-3cy5B:
undetectable		 5hrqB-3cy5B:
13.33
5hrqI-3cy5B:
5.65
5hrqJ-3cy5B:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 3cy5 HEMOGLOBIN SUBUNIT
BETA
(Bubalus
bubalis) 		5 / 12 LEU B  32
LEU B  48
HIS B  63
SER B  70
LEU B  31
 None
None
HEM  B 147 (-4.3A)
HEM  B 147 (-3.4A)
None
 1.14A 6ew0B-3cy5B:
undetectable		 6ew0B-3cy5B:
17.61