SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cyg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3cyg UNCHARACTERIZED
PROTEIN
(Fervidobacterium
nodosum) 		5 / 10 GLY A 223
HIS A 214
HIS A 136
GLY A 137
THR A 139
 None
 1.06A 1c9sN-3cygA:
undetectable
1c9sO-3cygA:
undetectable		 1c9sN-3cygA:
16.97
1c9sO-3cygA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3cyg UNCHARACTERIZED
PROTEIN
(Fervidobacterium
nodosum) 		5 / 11 GLY A 223
HIS A 214
HIS A 136
GLY A 137
THR A 139
 None
 1.07A 1c9sP-3cygA:
undetectable
1c9sQ-3cygA:
undetectable		 1c9sP-3cygA:
16.97
1c9sQ-3cygA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3cyg UNCHARACTERIZED
PROTEIN
(Fervidobacterium
nodosum) 		5 / 10 GLY A 137
THR A 139
GLY A 223
HIS A 214
HIS A 136
 None
 1.09A 1c9sL-3cygA:
undetectable
1c9sV-3cygA:
undetectable		 1c9sL-3cygA:
16.97
1c9sV-3cygA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3cyg UNCHARACTERIZED
PROTEIN
(Fervidobacterium
nodosum) 		5 / 11 GLY A 223
HIS A 214
HIS A 136
GLY A 137
THR A 139
 None
 1.11A 1gtfQ-3cygA:
undetectable
1gtfR-3cygA:
undetectable		 1gtfQ-3cygA:
16.97
1gtfR-3cygA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3cyg UNCHARACTERIZED
PROTEIN
(Fervidobacterium
nodosum) 		5 / 11 GLY A 223
HIS A 214
HIS A 136
GLY A 137
THR A 139
 None
 1.12A 1gtfS-3cygA:
undetectable
1gtfT-3cygA:
undetectable		 1gtfS-3cygA:
16.97
1gtfT-3cygA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 3cyg UNCHARACTERIZED
PROTEIN
(Fervidobacterium
nodosum) 		5 / 8 PHE A 227
ASP A 194
ILE A 191
PRO A 225
LEU A 217
 None
 1.28A 1hmyA-3cygA:
undetectable		 1hmyA-3cygA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3cyg UNCHARACTERIZED
PROTEIN
(Fervidobacterium
nodosum) 		5 / 12 VAL A 125
SER A 123
ASN A 145
GLY A 207
ILE A 209
 None
 1.06A 2dcfA-3cygA:
undetectable		 2dcfA-3cygA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 3cyg UNCHARACTERIZED
PROTEIN
(Fervidobacterium
nodosum) 		4 / 6 LEU A 156
SER A 198
ASP A 195
GLU A 165
 None
 1.17A 2j2pE-3cygA:
undetectable
2j2pF-3cygA:
undetectable		 2j2pE-3cygA:
17.97
2j2pF-3cygA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 3cyg UNCHARACTERIZED
PROTEIN
(Fervidobacterium
nodosum) 		5 / 10 ILE A 229
ILE A 209
ASN A 171
ARG A 115
ILE A 191
 None
 1.20A 2nnhB-3cygA:
undetectable		 2nnhB-3cygA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_1
(MDR769 HIV-1
PROTEASE)		 3cyg UNCHARACTERIZED
PROTEIN
(Fervidobacterium
nodosum) 		5 / 11 GLY A  91
ALA A  93
ASP A  96
ILE A 138
VAL A  53
 None
 0.97A 4l1aA-3cygA:
undetectable		 4l1aA-3cygA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3cyg UNCHARACTERIZED
PROTEIN
(Fervidobacterium
nodosum) 		5 / 10 PHE A 201
GLY A 207
ILE A 203
PHE A 197
ILE A 160
 None
 1.07A 6ebpB-3cygA:
undetectable		 6ebpB-3cygA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3cyg UNCHARACTERIZED
PROTEIN
(Fervidobacterium
nodosum) 		5 / 10 PHE A 201
GLY A 207
ILE A 203
PHE A 197
ILE A 160
 None
 1.09A 6ebpC-3cygA:
undetectable		 6ebpC-3cygA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3cyg UNCHARACTERIZED
PROTEIN
(Fervidobacterium
nodosum) 		5 / 11 PHE A 201
GLY A 207
ILE A 203
PHE A 197
ILE A 160
 None
 1.02A 6ebzA-3cygA:
undetectable		 6ebzA-3cygA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3cyg UNCHARACTERIZED
PROTEIN
(Fervidobacterium
nodosum) 		5 / 11 PHE A 201
GLY A 207
ILE A 203
PHE A 197
ILE A 160
 None
 1.06A 6ebzB-3cygA:
undetectable		 6ebzB-3cygA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3cyg UNCHARACTERIZED
PROTEIN
(Fervidobacterium
nodosum) 		5 / 11 PHE A 201
GLY A 207
ILE A 203
PHE A 197
ILE A 160
 None
 1.06A 6ebzC-3cygA:
undetectable		 6ebzC-3cygA:
17.80