SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cyj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 3cyj MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN
(Rubrobacter
xylanophilus) 		4 / 5 LEU A 114
LEU A 110
LEU A   9
GLY A  41
 None
 0.94A 1a4lC-3cyjA:
5.3		 1a4lC-3cyjA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 3cyj MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN
(Rubrobacter
xylanophilus) 		5 / 8 ALA A 106
LEU A  64
LEU A   9
LEU A 107
ALA A  68
 None
 1.48A 1e7cA-3cyjA:
undetectable		 1e7cA-3cyjA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 3cyj MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN
(Rubrobacter
xylanophilus) 		5 / 9 LEU A 230
ALA A 202
GLY A 195
ALA A 193
LEU A 218
 None
 1.06A 1nr6A-3cyjA:
undetectable		 1nr6A-3cyjA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 3cyj MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN
(Rubrobacter
xylanophilus) 		4 / 7 THR A  32
LEU A  36
SER A  12
VAL A  16
 None
 0.76A 1tyrB-3cyjA:
undetectable		 1tyrB-3cyjA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3cyj MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN
(Rubrobacter
xylanophilus) 		5 / 12 ALA A 155
GLY A 151
ILE A 158
ARG A 160
GLY A 184
 None
 0.88A 2qe6A-3cyjA:
undetectable		 2qe6A-3cyjA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3cyj MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN
(Rubrobacter
xylanophilus) 		4 / 5 GLU A 335
PRO A 334
ILE A 158
GLY A 336
 None
 0.95A 2qeuA-3cyjA:
undetectable
2qeuC-3cyjA:
undetectable		 2qeuA-3cyjA:
19.61
2qeuC-3cyjA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3cyj MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN
(Rubrobacter
xylanophilus) 		4 / 5 GLU A 335
PRO A 334
ILE A 158
GLY A 337
 None
 1.04A 2qeuA-3cyjA:
undetectable
2qeuC-3cyjA:
undetectable		 2qeuA-3cyjA:
19.61
2qeuC-3cyjA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 3cyj MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN
(Rubrobacter
xylanophilus) 		6 / 12 GLY A 152
GLY A 151
ASP A 333
PRO A 298
VAL A 130
LEU A 314
 None
 1.32A 3m6wA-3cyjA:
undetectable		 3m6wA-3cyjA:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 3cyj MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN
(Rubrobacter
xylanophilus) 		4 / 5 GLY A 229
ASP A 226
ARG A 227
GLN A 266
 None
 1.47A 3qx3A-3cyjA:
undetectable		 3qx3A-3cyjA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3cyj MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN
(Rubrobacter
xylanophilus) 		4 / 8 ASP A 319
ASP A 192
CYH A 296
GLU A  22
 None
NA  A 371 (-2.5A)
GOL  A 372 ( 4.3A)
None
 1.20A 4gkhD-3cyjA:
undetectable		 4gkhD-3cyjA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3cyj MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN
(Rubrobacter
xylanophilus) 		4 / 6 ILE A  35
THR A  33
VAL A 100
SER A  55
 None
 0.95A 4iaqA-3cyjA:
undetectable		 4iaqA-3cyjA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_1
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 3cyj MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN
(Rubrobacter
xylanophilus) 		4 / 5 TYR A 133
HIS A 313
ASP A 192
TYR A 248
 None
None
NA  A 371 (-2.5A)
None
 1.09A 4qdjA-3cyjA:
0.9		 4qdjA-3cyjA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 3cyj MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN
(Rubrobacter
xylanophilus) 		5 / 11 LEU A 314
LEU A 350
GLU A 324
ALA A 304
PHE A 328
 None
 1.27A 4wnuC-3cyjA:
undetectable		 4wnuC-3cyjA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)		 3cyj MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN
(Rubrobacter
xylanophilus) 		4 / 6 TYR A 248
HIS A 295
GLY A 246
GLU A 219
 None
GOL  A 372 (-4.7A)
None
NA  A 371 (-3.1A)
 1.34A 4zbqA-3cyjA:
undetectable		 4zbqA-3cyjA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3cyj MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN
(Rubrobacter
xylanophilus) 		4 / 8 THR A 270
SER A 301
ALA A 299
HIS A 295
 None
None
None
GOL  A 372 (-4.7A)
 0.95A 5eevL-3cyjA:
undetectable
5eevV-3cyjA:
undetectable		 5eevL-3cyjA:
12.19
5eevV-3cyjA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3cyj MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN
(Rubrobacter
xylanophilus) 		4 / 8 THR A 270
SER A 301
ALA A 299
HIS A 295
 None
None
None
GOL  A 372 (-4.7A)
 0.95A 5eewL-3cyjA:
undetectable
5eewV-3cyjA:
undetectable		 5eewL-3cyjA:
12.19
5eewV-3cyjA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3cyj MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN
(Rubrobacter
xylanophilus) 		4 / 8 THR A 270
SER A 301
ALA A 299
HIS A 295
 None
None
None
GOL  A 372 (-4.7A)
 0.95A 5ef3L-3cyjA:
undetectable
5ef3V-3cyjA:
undetectable		 5ef3L-3cyjA:
12.19
5ef3V-3cyjA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 3cyj MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN
(Rubrobacter
xylanophilus) 		4 / 6 THR A 270
SER A 301
VAL A 300
HIS A 320
 None
 1.13A 5ewuA-3cyjA:
undetectable		 5ewuA-3cyjA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 3cyj MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN
(Rubrobacter
xylanophilus) 		3 / 3 GLU A 129
HIS A 127
VAL A 130
 None
 0.92A 5trqB-3cyjA:
undetectable		 5trqB-3cyjA:
20.95