SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cyv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 3cyv UROPORPHYRINOGEN
DECARBOXYLASE
(Shigella
flexneri) 		4 / 5 GLY A 146
LEU A 151
THR A 150
VAL A 189
 None
 0.84A 1ekjF-3cyvA:
undetectable
1ekjG-3cyvA:
undetectable		 1ekjF-3cyvA:
21.47
1ekjG-3cyvA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1433_1
(CHITINASE)		 3cyv UROPORPHYRINOGEN
DECARBOXYLASE
(Shigella
flexneri) 		4 / 5 TYR A 123
MET A  47
ASP A  77
PHE A 144
 None
 0.95A 2a3bA-3cyvA:
9.7		 2a3bA-3cyvA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 3cyv UROPORPHYRINOGEN
DECARBOXYLASE
(Shigella
flexneri) 		5 / 9 GLY A 339
GLU A 336
ILE A 304
ALA A 344
VAL A 308
 None
 1.20A 2drdA-3cyvA:
undetectable		 2drdA-3cyvA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3cyv UROPORPHYRINOGEN
DECARBOXYLASE
(Shigella
flexneri) 		4 / 6 THR A 249
ASP A 270
THR A 272
ASP A 293
 None
 0.99A 2okcB-3cyvA:
undetectable		 2okcB-3cyvA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 3cyv UROPORPHYRINOGEN
DECARBOXYLASE
(Shigella
flexneri) 		5 / 12 LEU A 235
LEU A 151
ILE A 197
VAL A  81
ILE A  78
 None
 0.83A 3frqB-3cyvA:
undetectable		 3frqB-3cyvA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 3cyv UROPORPHYRINOGEN
DECARBOXYLASE
(Shigella
flexneri) 		5 / 10 ILE A 167
LEU A 178
THR A 153
ASP A 208
GLY A 211
 None
 1.23A 4bwlC-3cyvA:
6.4		 4bwlC-3cyvA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_ACTA402_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 3cyv UROPORPHYRINOGEN
DECARBOXYLASE
(Shigella
flexneri) 		3 / 3 LYS A  37
TYR A  36
ARG A  40
 None
 1.41A 4gc9A-3cyvA:
undetectable		 4gc9A-3cyvA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 3cyv UROPORPHYRINOGEN
DECARBOXYLASE
(Shigella
flexneri) 		4 / 8 VAL A 139
PRO A  22
GLN A  28
ILE A 142
 None
 1.01A 4iilA-3cyvA:
2.2		 4iilA-3cyvA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3cyv UROPORPHYRINOGEN
DECARBOXYLASE
(Shigella
flexneri) 		5 / 12 SER A 223
GLY A 253
GLY A 252
LEU A 269
ASP A 274
 None
 1.13A 4pghD-3cyvA:
undetectable		 4pghD-3cyvA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3cyv UROPORPHYRINOGEN
DECARBOXYLASE
(Shigella
flexneri) 		4 / 8 SER A 223
TRP A 149
ALA A 152
LEU A 151
 None
 1.05A 4rkuA-3cyvA:
undetectable
4rkuJ-3cyvA:
undetectable		 4rkuA-3cyvA:
20.09
4rkuJ-3cyvA:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 3cyv UROPORPHYRINOGEN
DECARBOXYLASE
(Shigella
flexneri) 		4 / 7 SER A 223
TRP A 149
ALA A 152
LEU A 151
 None
 1.03A 4xk8A-3cyvA:
undetectable		 4xk8A-3cyvA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_C_SAMC301_0
(NS5)		 3cyv UROPORPHYRINOGEN
DECARBOXYLASE
(Shigella
flexneri) 		5 / 12 GLY A 212
GLY A 252
VAL A 245
ASP A 208
ILE A 206
 None
 0.88A 5njvC-3cyvA:
undetectable		 5njvC-3cyvA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 3cyv UROPORPHYRINOGEN
DECARBOXYLASE
(Shigella
flexneri) 		4 / 6 ARG A   8
ARG A  11
ALA A  12
PRO A  22
 None
 1.43A 5odqA-3cyvA:
2.1		 5odqA-3cyvA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 3cyv UROPORPHYRINOGEN
DECARBOXYLASE
(Shigella
flexneri) 		4 / 7 GLY A 251
TRP A 210
TYR A 154
ASP A 208
 None
 1.15A 5vlmG-3cyvA:
undetectable		 5vlmG-3cyvA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 3cyv UROPORPHYRINOGEN
DECARBOXYLASE
(Shigella
flexneri) 		5 / 12 ARG A  27
GLY A 328
THR A 249
GLY A 211
GLY A 212
 None
 1.21A 6brdB-3cyvA:
undetectable		 6brdB-3cyvA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 3cyv UROPORPHYRINOGEN
DECARBOXYLASE
(Shigella
flexneri) 		4 / 8 LEU A  61
LEU A  64
LEU A  74
GLY A 143
 None
 0.83A 6ce2A-3cyvA:
undetectable		 6ce2A-3cyvA:
14.33