SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3czm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_1
(PROTEIN (ADENOSINE
KINASE))		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 ASP A 143
GLY A 288
GLY A 193
ASN A 165
ASP A 168
 None
 0.94A 1bx4A-3czmA:
2.4		 1bx4A-3czmA:
21.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 9 GLY A  27
ASP A  53
ALA A  98
ILE A 119
GLU A 122
 NAD  A 401 ( 3.8A)
NAD  A 401 (-2.9A)
NAD  A 401 (-3.4A)
NAD  A 401 (-3.9A)
NAD  A 401 (-3.4A)
 0.45A 1cetA-3czmA:
44.9		 1cetA-3czmA:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 9 GLY A  27
ASP A  53
TYR A  85
ALA A  98
ILE A 119
 NAD  A 401 ( 3.8A)
NAD  A 401 (-2.9A)
None
NAD  A 401 (-3.4A)
NAD  A 401 (-3.9A)
 0.69A 1cetA-3czmA:
44.9		 1cetA-3czmA:
48.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 8 MET A 219
GLN A 179
GLU A 227
ASP A 178
 None
 1.17A 1dtlA-3czmA:
undetectable		 1dtlA-3czmA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_1
(ADENOSINE KINASE)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 ASP A 143
GLY A 288
GLY A 193
ASN A 165
ASP A 168
 None
 1.04A 1liiA-3czmA:
5.8		 1liiA-3czmA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 7 GLY A 237
ARG A 109
ILE A 239
VAL A 240
 None
OXQ  A 708 (-4.0A)
None
None
 0.92A 1rxcC-3czmA:
undetectable		 1rxcC-3czmA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B17_A_DIFA701_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 10 ALA A 254
ILE A  95
GLY A 162
HIS A 195
ASP A 143
 None
None
None
OXQ  A 708 ( 3.7A)
None
 1.39A 2b17A-3czmA:
undetectable		 2b17A-3czmA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_A_ADNA1301_1
(SUGAR KINASE MJ0406)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 ASP A 143
GLY A 288
GLY A 193
ASN A 165
ASP A 168
 None
 1.04A 2c49A-3czmA:
5.9		 2c49A-3czmA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 9 LEU A 289
ILE A 192
LEU A 305
ILE A 303
TYR A 279
 None
 1.19A 2f7aA-3czmA:
undetectable		 2f7aA-3czmA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 ASP A 143
GLY A 288
GLY A 193
ASN A 165
ASP A 168
 None
 1.04A 2pkkA-3czmA:
6.6		 2pkkA-3czmA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 10 ILE A  23
ILE A  95
VAL A 138
GLY A 162
VAL A 127
 None
None
NAD  A 401 (-4.5A)
None
None
 1.20A 3elzC-3czmA:
undetectable		 3elzC-3czmA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 10 ILE A  23
ILE A  95
VAL A 138
GLY A 162
VAL A 127
 None
None
NAD  A 401 (-4.5A)
None
None
 1.21A 3em0A-3czmA:
undetectable		 3em0A-3czmA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 5 VAL A  54
TYR A  85
ILE A  26
ALA A  98
 NAD  A 401 (-4.2A)
None
None
NAD  A 401 (-3.4A)
 0.91A 3n8yB-3czmA:
undetectable		 3n8yB-3czmA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		3 / 3 ASP A 111
GLU A 324
SER A 103
 None
 0.82A 3p2kA-3czmA:
4.8		 3p2kA-3czmA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROZ_A_NCAA266_0
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 6 ASP A  66
LEU A  51
ALA A 251
LEU A  39
 None
 1.10A 3rozA-3czmA:
undetectable		 3rozA-3czmA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 7 ILE A 255
PHE A 134
MET A 159
GLY A 297
 None
 1.04A 3sj0X-3czmA:
undetectable		 3sj0X-3czmA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_A_ADNA353_1
(ADENOSINE KINASE)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		6 / 12 ASP A 143
GLY A 288
GLY A 193
ASN A 165
ARG A 109
ASP A 168
 None
None
None
None
OXQ  A 708 (-4.0A)
None
 0.99A 3uboA-3czmA:
6.0		 3uboA-3czmA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_1
(ADENOSINE KINASE)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 ASP A 143
GLY A 288
GLY A 193
ASN A 165
ASP A 168
 None
 0.99A 3uboB-3czmA:
6.1		 3uboB-3czmA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 5 GLY A 295
GLY A 296
MET A 159
ASN A 158
 None
 1.29A 4fglC-3czmA:
5.1		 4fglC-3czmA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 5 GLY A 295
GLY A 297
MET A 159
ASN A 158
 None
 1.12A 4fglC-3czmA:
5.1		 4fglC-3czmA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 6 GLY A 294
GLY A 297
MET A 159
ASN A 158
 None
 0.99A 4fglD-3czmA:
2.1		 4fglD-3czmA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 ASP A 143
GLY A 288
GLY A 193
ASN A 165
ASP A 168
 None
 0.98A 4jksA-3czmA:
6.3		 4jksA-3czmA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 ASP A 143
GLY A 288
GLY A 193
ASN A 165
ASP A 168
 None
 0.98A 4jksB-3czmA:
6.2		 4jksB-3czmA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_A_ADNA500_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 ASP A 143
GLY A 288
GLY A 193
ASN A 165
ASP A 168
 None
 0.99A 4jkuA-3czmA:
6.8		 4jkuA-3czmA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_B_ADNB500_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 ASP A 143
GLY A 288
GLY A 193
ASN A 165
ASP A 168
 None
 1.00A 4jkuB-3czmA:
6.2		 4jkuB-3czmA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_1
(SUGAR KINASE)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 ASP A 143
GLY A 288
GLY A 193
ASN A 165
ASP A 168
 None
 0.99A 4k8cA-3czmA:
6.7		 4k8cA-3czmA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_B_ADNB401_1
(SUGAR KINASE)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 ASP A 143
GLY A 288
GLY A 193
ASN A 165
ASP A 168
 None
 0.98A 4k8cB-3czmA:
3.2		 4k8cB-3czmA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_A_ADNA401_1
(SUGAR KINASE)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 ASP A 143
GLY A 288
GLY A 193
ASN A 165
ASP A 168
 None
 0.97A 4k8kA-3czmA:
6.3		 4k8kA-3czmA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_B_ADNB403_1
(SUGAR KINASE)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 ASP A 143
GLY A 288
GLY A 193
ASN A 165
ASP A 168
 None
 0.97A 4k8kB-3czmA:
6.2		 4k8kB-3czmA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_A_ADNA401_1
(SUGAR KINASE)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 ASP A 143
GLY A 288
GLY A 193
ASN A 165
ASP A 168
 None
 1.01A 4k8pA-3czmA:
3.1		 4k8pA-3czmA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_B_ADNB401_1
(SUGAR KINASE)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 ASP A 143
GLY A 288
GLY A 193
ASN A 165
ASP A 168
 None
 0.99A 4k8pB-3czmA:
3.0		 4k8pB-3czmA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_B_ADNB401_1
(SUGAR KINASE)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 ASP A 143
GLY A 288
GLY A 193
ASN A 165
ASP A 168
 None
 1.00A 4k8tB-3czmA:
6.2		 4k8tB-3czmA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_A_ADNA401_1
(SUGAR KINASE)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 ASP A 143
GLY A 288
GLY A 193
ASN A 165
ASP A 168
 None
 0.98A 4k93A-3czmA:
6.8		 4k93A-3czmA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_B_ADNB402_1
(SUGAR KINASE)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 ASP A 143
GLY A 288
GLY A 193
ASN A 165
ASP A 168
 None
 1.00A 4k93B-3czmA:
6.2		 4k93B-3czmA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_A_ADNA401_1
(SUGAR KINASE)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 ASP A 143
GLY A 288
GLY A 193
ASN A 165
ASP A 168
 None
 0.99A 4k9cA-3czmA:
6.2		 4k9cA-3czmA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_B_ADNB401_1
(SUGAR KINASE)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 ASP A 143
GLY A 288
GLY A 193
ASN A 165
ASP A 168
 None
 1.00A 4k9cB-3czmA:
6.2		 4k9cB-3czmA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_A_ADNA401_1
(SUGAR KINASE)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 ASP A 143
GLY A 288
GLY A 193
ASN A 165
ASP A 168
 None
 0.98A 4k9iA-3czmA:
6.2		 4k9iA-3czmA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_B_ADNB401_1
(SUGAR KINASE)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 ASP A 143
GLY A 288
GLY A 193
ASN A 165
ASP A 168
 None
 0.98A 4k9iB-3czmA:
6.2		 4k9iB-3czmA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 ASP A 143
GLY A 288
GLY A 193
ASN A 165
ASP A 168
 None
 0.98A 4kadA-3czmA:
2.5		 4kadA-3czmA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 ASP A 143
GLY A 288
GLY A 193
ASN A 165
ASP A 168
 None
 0.97A 4kadB-3czmA:
6.9		 4kadB-3czmA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 ASP A 143
GLY A 288
GLY A 193
ASN A 165
ASP A 168
 None
 0.98A 4kahA-3czmA:
6.8		 4kahA-3czmA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 ASP A 143
GLY A 288
GLY A 193
ASN A 165
ASP A 168
 None
 0.99A 4kahB-3czmA:
6.3		 4kahB-3czmA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 ASP A 143
GLY A 288
GLY A 193
ASN A 165
ASP A 168
 None
 1.00A 4kalA-3czmA:
6.1		 4kalA-3czmA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 ASP A 143
GLY A 288
GLY A 193
ASN A 165
ASP A 168
 None
 0.97A 4kalB-3czmA:
6.2		 4kalB-3czmA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 ASP A 143
GLY A 288
GLY A 193
ASN A 165
ASP A 168
 None
 0.98A 4kanA-3czmA:
6.9		 4kanA-3czmA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 ASP A 143
GLY A 288
GLY A 193
ASN A 165
ASP A 168
 None
 0.99A 4kanB-3czmA:
6.3		 4kanB-3czmA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 ASP A 143
GLY A 288
GLY A 193
ASN A 165
ASP A 168
 None
 0.99A 4kbeA-3czmA:
6.8		 4kbeA-3czmA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 ASP A 143
GLY A 288
GLY A 193
ASN A 165
ASP A 168
 None
 0.99A 4kbeB-3czmA:
6.8		 4kbeB-3czmA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 ASP A 143
GLY A 288
GLY A 193
ASN A 165
ASP A 168
 None
 0.97A 4lbgA-3czmA:
6.4		 4lbgA-3czmA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 ASP A 143
GLY A 288
GLY A 193
ASN A 165
ASP A 168
 None
 0.98A 4lbgB-3czmA:
6.2		 4lbgB-3czmA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 ASP A 143
GLY A 288
GLY A 193
ASN A 165
ASP A 168
 None
 0.98A 4lbxA-3czmA:
6.3		 4lbxA-3czmA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 ASP A 143
GLY A 288
GLY A 193
ASN A 165
ASP A 168
 None
 1.00A 4lbxB-3czmA:
6.2		 4lbxB-3czmA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 ASP A 143
GLY A 288
GLY A 193
ASN A 165
ASP A 168
 None
 0.99A 4lc4A-3czmA:
6.2		 4lc4A-3czmA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 ASP A 143
GLY A 288
GLY A 193
ASN A 165
ASP A 168
 None
 0.98A 4lc4B-3czmA:
6.1		 4lc4B-3czmA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 ASP A 143
GLY A 288
GLY A 193
ASN A 165
ASP A 168
 None
 1.00A 4lcaA-3czmA:
6.2		 4lcaA-3czmA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 ASP A 143
GLY A 288
GLY A 193
ASN A 165
ASP A 168
 None
 0.99A 4lcaB-3czmA:
6.3		 4lcaB-3czmA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_1
(ADENOSINE KINASE)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 ASP A 143
GLY A 288
GLY A 193
ASN A 165
ASP A 168
 None
 1.00A 4n09B-3czmA:
5.9		 4n09B-3czmA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_1
(ADENOSINE KINASE)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 ASP A 143
GLY A 288
GLY A 193
ASN A 165
ASP A 168
 None
 0.99A 4n09D-3czmA:
5.9		 4n09D-3czmA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		3 / 3 ASP A 111
ASN A 140
SER A 103
 None
OXQ  A 708 ( 3.4A)
None
 0.83A 4obwA-3czmA:
4.8		 4obwA-3czmA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKN_B_KANB403_1
(L-LACTATE
DEHYDROGENASE A
CHAIN)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 9 ASP A  53
VAL A  54
TYR A  85
ALA A  98
ILE A 119
 NAD  A 401 (-2.9A)
NAD  A 401 (-4.2A)
None
NAD  A 401 (-3.4A)
NAD  A 401 (-3.9A)
 0.66A 4oknB-3czmA:
38.6		 4oknB-3czmA:
29.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 ILE A  95
ALA A 251
THR A  70
VAL A  76
LEU A  51
 None
 1.24A 4qzuA-3czmA:
undetectable		 4qzuA-3czmA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 PHE A 115
GLY A  99
ALA A  98
ASN A 140
PRO A 114
 None
NAD  A 401 (-4.4A)
NAD  A 401 (-3.4A)
OXQ  A 708 ( 3.4A)
None
 1.11A 4rtpA-3czmA:
4.2		 4rtpA-3czmA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 ASP A 143
GLY A 288
GLY A 193
ASN A 165
ASP A 168
 None
 1.04A 4ubeA-3czmA:
7.1		 4ubeA-3czmA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		3 / 3 TYR A 205
THR A 207
THR A 190
 None
 0.72A 5aoxB-3czmA:
undetectable		 5aoxB-3czmA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_F_ACTF1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		3 / 3 TYR A 205
THR A 207
THR A 190
 None
 0.69A 5aoxE-3czmA:
undetectable		 5aoxE-3czmA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 GLY A  37
ALA A  46
ALA A  24
LEU A  51
ALA A  69
 None
 1.06A 5bw4B-3czmA:
4.7		 5bw4B-3czmA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 6 SER A  67
GLY A  27
ASP A  53
GLY A  32
 None
NAD  A 401 ( 3.8A)
NAD  A 401 (-2.9A)
None
 0.93A 5cdpA-3czmA:
undetectable
5cdpB-3czmA:
undetectable		 5cdpA-3czmA:
20.20
5cdpB-3czmA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 ASN A 110
ASP A 143
LEU A 281
PHE A 315
ILE A 287
 None
 1.05A 5dv4A-3czmA:
undetectable		 5dv4A-3czmA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYI_B_NIZB806_1
(CATALASE-PEROXIDASE)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 5 ARG A 109
HIS A 195
PRO A 250
SER A 245
 OXQ  A 708 (-4.0A)
OXQ  A 708 ( 3.7A)
NAD  A 401 ( 4.5A)
OXQ  A 708 (-3.0A)
 1.48A 5syiB-3czmA:
undetectable		 5syiB-3czmA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA810_1
(CATALASE-PEROXIDASE)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 6 ARG A 109
HIS A 195
PRO A 250
SER A 245
 OXQ  A 708 (-4.0A)
OXQ  A 708 ( 3.7A)
NAD  A 401 ( 4.5A)
OXQ  A 708 (-3.0A)
 1.48A 5syjA-3czmA:
undetectable		 5syjA-3czmA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB810_1
(CATALASE-PEROXIDASE)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 6 ARG A 109
HIS A 195
PRO A 250
SER A 245
 OXQ  A 708 (-4.0A)
OXQ  A 708 ( 3.7A)
NAD  A 401 ( 4.5A)
OXQ  A 708 (-3.0A)
 1.49A 5syjB-3czmA:
undetectable		 5syjB-3czmA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 6 GLY A  37
TYR A  38
LEU A  45
VAL A  76
 None
 0.98A 5x80A-3czmA:
undetectable
5x80B-3czmA:
undetectable		 5x80A-3czmA:
21.43
5x80B-3czmA:
21.43