SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3czp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)		 3czp PUTATIVE
POLYPHOSPHATE KINASE
2
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 450
VAL A 448
TRP A 408
 None
 0.89A 1grmA-3czpA:
undetectable		 1grmA-3czpA:
3.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)		 3czp PUTATIVE
POLYPHOSPHATE KINASE
2
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 450
VAL A 448
TRP A 408
 None
 0.89A 1grmB-3czpA:
undetectable		 1grmB-3czpA:
3.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XR2_B_C2FB1201_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 3czp PUTATIVE
POLYPHOSPHATE KINASE
2
(Pseudomonas
aeruginosa) 		4 / 8 LYS A 311
TRP A 408
SER A 364
ARG A 363
 GOL  A 610 (-4.9A)
None
None
None
 1.25A 1xr2B-3czpA:
undetectable		 1xr2B-3czpA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 3czp PUTATIVE
POLYPHOSPHATE KINASE
2
(Pseudomonas
aeruginosa) 		4 / 5 VAL A  58
THR A  57
VAL A 223
GLY A 224
 None
 1.13A 2p2fA-3czpA:
undetectable		 2p2fA-3czpA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 3czp PUTATIVE
POLYPHOSPHATE KINASE
2
(Pseudomonas
aeruginosa) 		4 / 4 VAL A  58
THR A  57
VAL A 223
GLY A 224
 None
 1.14A 2p2fB-3czpA:
undetectable		 2p2fB-3czpA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)		 3czp PUTATIVE
POLYPHOSPHATE KINASE
2
(Pseudomonas
aeruginosa) 		5 / 9 PHE A 148
ILE A 226
LEU A  61
PHE A 150
THR A 101
 ACT  A 608 ( 4.5A)
None
None
None
None
 1.36A 2tsrD-3czpA:
undetectable		 2tsrD-3czpA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 3czp PUTATIVE
POLYPHOSPHATE KINASE
2
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 370
ILE A 390
ALA A 386
ARG A 340
GLU A 339
 None
 1.25A 2v0mC-3czpA:
undetectable		 2v0mC-3czpA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)		 3czp PUTATIVE
POLYPHOSPHATE KINASE
2
(Pseudomonas
aeruginosa) 		3 / 3 TRP A 444
GLN A 446
TRP A 438
 None
 1.30A 2vqyA-3czpA:
undetectable		 2vqyA-3czpA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3czp PUTATIVE
POLYPHOSPHATE KINASE
2
(Pseudomonas
aeruginosa) 		5 / 12 PHE A  91
GLN A 111
SER A 110
LEU A 147
LEU A  76
 None
 1.11A 3adxA-3czpA:
undetectable		 3adxA-3czpA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3czp PUTATIVE
POLYPHOSPHATE KINASE
2
(Pseudomonas
aeruginosa) 		5 / 12 PHE A  91
GLN A 111
SER A 110
PHE A 104
LEU A  76
 None
 1.26A 3adxA-3czpA:
undetectable		 3adxA-3czpA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 3czp PUTATIVE
POLYPHOSPHATE KINASE
2
(Pseudomonas
aeruginosa) 		4 / 8 LEU A 159
ILE A  49
HIS A 153
GLY A 194
 None
 0.96A 3b9lA-3czpA:
undetectable		 3b9lA-3czpA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 3czp PUTATIVE
POLYPHOSPHATE KINASE
2
(Pseudomonas
aeruginosa) 		5 / 12 GLN A 342
PHE A 104
ILE A 103
GLY A 102
VAL A  72
 None
 1.01A 3fpjA-3czpA:
undetectable		 3fpjA-3czpA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)		 3czp PUTATIVE
POLYPHOSPHATE KINASE
2
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 481
GLY A 313
ALA A 314
ILE A 329
VAL A 480
 None
 1.04A 3ucbA-3czpA:
undetectable		 3ucbA-3czpA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)		 3czp PUTATIVE
POLYPHOSPHATE KINASE
2
(Pseudomonas
aeruginosa) 		5 / 12 TYR A 366
VAL A 300
ALA A 301
PHE A 393
SER A 364
 None
 1.26A 4mm6A-3czpA:
undetectable		 4mm6A-3czpA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 3czp PUTATIVE
POLYPHOSPHATE KINASE
2
(Pseudomonas
aeruginosa) 		4 / 7 ALA A 206
GLY A 144
ALA A 145
GLU A 143
 None
 0.81A 4r1zB-3czpA:
undetectable		 4r1zB-3czpA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3czp PUTATIVE
POLYPHOSPHATE KINASE
2
(Pseudomonas
aeruginosa) 		4 / 6 TYR A 109
ASN A  47
GLU A 137
PHE A  91
 None
 1.43A 4twdG-3czpA:
undetectable
4twdH-3czpA:
0.8		 4twdG-3czpA:
18.77
4twdH-3czpA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 3czp PUTATIVE
POLYPHOSPHATE KINASE
2
(Pseudomonas
aeruginosa) 		4 / 5 ARG A 477
GLY A 313
ALA A 314
GLY A 310
 None
None
None
GOL  A 610 (-3.5A)
 0.86A 4u9uA-3czpA:
2.0		 4u9uA-3czpA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 3czp PUTATIVE
POLYPHOSPHATE KINASE
2
(Pseudomonas
aeruginosa) 		4 / 5 ARG A 477
GLY A 313
ALA A 314
GLY A 310
 None
None
None
GOL  A 610 (-3.5A)
 0.89A 4u9uB-3czpA:
2.4		 4u9uB-3czpA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3czp PUTATIVE
POLYPHOSPHATE KINASE
2
(Pseudomonas
aeruginosa) 		5 / 10 ALA A 301
ILE A 360
TYR A 327
GLY A 312
PHE A 303
 None
None
None
GOL  A 610 ( 4.5A)
None
 1.16A 5i6xA-3czpA:
0.4		 5i6xA-3czpA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3czp PUTATIVE
POLYPHOSPHATE KINASE
2
(Pseudomonas
aeruginosa) 		5 / 12 ASN A 107
GLY A 106
LEU A 227
GLY A 102
ILE A  43
 None
 1.14A 5vooB-3czpA:
undetectable		 5vooB-3czpA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3czp PUTATIVE
POLYPHOSPHATE KINASE
2
(Pseudomonas
aeruginosa) 		5 / 10 LYS A  54
TYR A 109
GLY A  48
TRP A 108
LEU A  45
 None
 1.42A 6bsiA-3czpA:
undetectable		 6bsiA-3czpA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3czp PUTATIVE
POLYPHOSPHATE KINASE
2
(Pseudomonas
aeruginosa) 		5 / 10 LYS A  54
TYR A 109
GLY A  48
TRP A 108
LEU A  45
 None
 1.31A 6bsjA-3czpA:
undetectable		 6bsjA-3czpA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 3czp PUTATIVE
POLYPHOSPHATE KINASE
2
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 278
GLY A 313
VAL A 318
LEU A 481
ILE A 484
 None
 1.02A 6ecxA-3czpA:
undetectable		 6ecxA-3czpA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 3czp PUTATIVE
POLYPHOSPHATE KINASE
2
(Pseudomonas
aeruginosa) 		3 / 3 TRP A 151
GLU A   6
GLU A 195
 None
 1.01A 6fhwA-3czpA:
undetectable		 6fhwA-3czpA:
10.08