SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3d00'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)		 3d00 TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT E
(Syntrophus
aciditrophicus) 		5 / 9 LEU A 130
ILE A 134
PHE A  84
VAL A  29
GLY A  32
 None
 1.26A 1e7aB-3d00A:
undetectable		 1e7aB-3d00A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3d00 TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT E
(Syntrophus
aciditrophicus) 		3 / 3 ASN A  73
TRP A  75
GLN A  64
 None
 1.43A 1xoqA-3d00A:
undetectable		 1xoqA-3d00A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 3d00 TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT E
(Syntrophus
aciditrophicus) 		5 / 11 LEU A 144
ALA A  39
LYS A  41
LEU A  43
VAL A 147
 None
 1.28A 3e22B-3d00A:
undetectable		 3e22B-3d00A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 3d00 TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT E
(Syntrophus
aciditrophicus) 		3 / 3 PRO A  68
THR A  67
LEU A  76
 None
 0.64A 3ttrA-3d00A:
undetectable		 3ttrA-3d00A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3d00 TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT E
(Syntrophus
aciditrophicus) 		3 / 3 ALA A  39
ASN A  42
LEU A  43
 None
 0.21A 5i1nC-3d00A:
undetectable		 5i1nC-3d00A:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3d00 TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT E
(Syntrophus
aciditrophicus) 		3 / 3 ALA A  39
ASN A  42
LEU A  43
 None
 0.28A 5i1oC-3d00A:
undetectable		 5i1oC-3d00A:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3d00 TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT E
(Syntrophus
aciditrophicus) 		3 / 3 ALA A  39
ASN A  42
LEU A  43
 None
 0.22A 5i1pA-3d00A:
undetectable		 5i1pA-3d00A:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3d00 TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT E
(Syntrophus
aciditrophicus) 		3 / 3 ALA A  39
ASN A  42
LEU A  43
 None
 0.36A 5i1pD-3d00A:
undetectable		 5i1pD-3d00A:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3d00 TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT E
(Syntrophus
aciditrophicus) 		3 / 3 ALA A  51
GLN A  64
THR A  67
 None
 0.71A 5n0oA-3d00A:
undetectable		 5n0oA-3d00A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 3d00 TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT E
(Syntrophus
aciditrophicus) 		4 / 5 PHE A 100
PHE A  84
LEU A 101
LEU A  88
 None
 1.37A 5veuH-3d00A:
undetectable		 5veuH-3d00A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6I_A_8PRA509_1
(ENVELOPE
GLYCOPROTEIN,GP,GP1
ENVELOPE
GLYCOPROTEIN)		 3d00 TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT E
(Syntrophus
aciditrophicus) 		5 / 12 GLU A 133
ALA A 137
GLY A 138
LEU A 142
LEU A 101
 None
 1.17A 6f6iA-3d00A:
undetectable
6f6iB-3d00A:
undetectable		 6f6iA-3d00A:
20.22
6f6iB-3d00A:
18.67