SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3d0c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3d0c DIHYDRODIPICOLINATE
SYNTHASE
(Oceanobacillus
iheyensis) 		4 / 4 ILE A  28
LEU A  33
VAL A  72
ALA A  80
 None
 0.98A 1mz9A-3d0cA:
undetectable		 1mz9A-3d0cA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3d0c DIHYDRODIPICOLINATE
SYNTHASE
(Oceanobacillus
iheyensis) 		4 / 5 ILE A  28
LEU A  33
VAL A  72
ALA A  80
 None
 0.94A 1mz9C-3d0cA:
undetectable		 1mz9C-3d0cA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3d0c DIHYDRODIPICOLINATE
SYNTHASE
(Oceanobacillus
iheyensis) 		4 / 6 LEU A  60
VAL A  47
VAL A  72
ILE A  16
 None
 0.94A 2hyyA-3d0cA:
undetectable		 2hyyA-3d0cA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3d0c DIHYDRODIPICOLINATE
SYNTHASE
(Oceanobacillus
iheyensis) 		4 / 6 LEU A  60
VAL A  47
VAL A  72
ILE A  16
 None
 0.98A 2hyyB-3d0cA:
undetectable		 2hyyB-3d0cA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 3d0c DIHYDRODIPICOLINATE
SYNTHASE
(Oceanobacillus
iheyensis) 		4 / 8 GLY A  52
ILE A 262
ASN A 215
GLU A  56
 None
 0.89A 2x0pA-3d0cA:
undetectable		 2x0pA-3d0cA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 3d0c DIHYDRODIPICOLINATE
SYNTHASE
(Oceanobacillus
iheyensis) 		3 / 3 ASP A 242
THR A  12
GLU A 195
 None
 0.76A 2zifB-3d0cA:
undetectable		 2zifB-3d0cA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3d0c DIHYDRODIPICOLINATE
SYNTHASE
(Oceanobacillus
iheyensis) 		4 / 6 LEU A  60
VAL A  47
VAL A  72
ILE A  16
 None
 1.03A 3k5vA-3d0cA:
undetectable		 3k5vA-3d0cA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3d0c DIHYDRODIPICOLINATE
SYNTHASE
(Oceanobacillus
iheyensis) 		4 / 6 LEU A  60
VAL A  47
VAL A  72
ILE A  16
 None
 0.99A 3k5vB-3d0cA:
undetectable		 3k5vB-3d0cA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3d0c DIHYDRODIPICOLINATE
SYNTHASE
(Oceanobacillus
iheyensis) 		4 / 4 LYS A   8
PHE A  10
PHE A 189
VAL A 181
 None
 1.08A 3rv5A-3d0cA:
0.0
3rv5B-3d0cA:
undetectable		 3rv5A-3d0cA:
16.39
3rv5B-3d0cA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 3d0c DIHYDRODIPICOLINATE
SYNTHASE
(Oceanobacillus
iheyensis) 		4 / 7 TYR A 166
ILE A 152
GLY A 163
PHE A 189
 None
 0.87A 4iqqA-3d0cA:
undetectable		 4iqqA-3d0cA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 3d0c DIHYDRODIPICOLINATE
SYNTHASE
(Oceanobacillus
iheyensis) 		4 / 4 VAL A 151
ALA A 121
ILE A 118
THR A 119
 None
 1.08A 5e4dB-3d0cA:
undetectable		 5e4dB-3d0cA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 3d0c DIHYDRODIPICOLINATE
SYNTHASE
(Oceanobacillus
iheyensis) 		4 / 7 TYR A 166
ILE A 152
GLY A 163
PHE A 189
 None
 0.86A 5nooA-3d0cA:
undetectable		 5nooA-3d0cA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)		 3d0c DIHYDRODIPICOLINATE
SYNTHASE
(Oceanobacillus
iheyensis) 		4 / 6 ILE A  18
ASP A  34
LEU A  33
GLY A  32
 None
 0.90A 5x5qE-3d0cA:
undetectable		 5x5qE-3d0cA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 3d0c DIHYDRODIPICOLINATE
SYNTHASE
(Oceanobacillus
iheyensis) 		5 / 12 PRO A 137
ILE A 139
VAL A 108
VAL A  83
ASP A 106
 None
 1.02A 6emuC-3d0cA:
undetectable		 6emuC-3d0cA:
20.95