SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3d0q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 3d0q PROTEIN CALG3
(Micromonospora
echinospora) 		6 / 12 ILE A 227
LEU A 259
PRO A 260
VAL A 263
LEU A 246
ILE A 253
 None
 1.39A 1df7A-3d0qA:
undetectable		 1df7A-3d0qA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 3d0q PROTEIN CALG3
(Micromonospora
echinospora) 		5 / 12 VAL A 282
ILE A 234
GLY A 238
ALA A 237
LEU A 337
 None
 0.96A 1eqhA-3d0qA:
undetectable		 1eqhA-3d0qA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 3d0q PROTEIN CALG3
(Micromonospora
echinospora) 		5 / 12 VAL A 282
ILE A 234
GLY A 238
ALA A 237
LEU A 337
 None
 0.97A 1eqhB-3d0qA:
undetectable		 1eqhB-3d0qA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3d0q PROTEIN CALG3
(Micromonospora
echinospora) 		4 / 5 GLY A  86
GLN A  88
TRP A  85
VAL A  74
 None
 1.21A 1p6kB-3d0qA:
undetectable		 1p6kB-3d0qA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG1_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 3d0q PROTEIN CALG3
(Micromonospora
echinospora) 		3 / 3 TRP A 191
VAL A 192
PRO A 193
 None
 0.57A 1rg1A-3d0qA:
undetectable		 1rg1A-3d0qA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH0_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 3d0q PROTEIN CALG3
(Micromonospora
echinospora) 		3 / 3 TRP A 191
VAL A 192
PRO A 193
 None
 0.57A 1rh0A-3d0qA:
undetectable		 1rh0A-3d0qA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3d0q PROTEIN CALG3
(Micromonospora
echinospora) 		4 / 5 GLY A  86
GLN A  88
TRP A  85
VAL A  74
 None
 1.19A 1rs6B-3d0qA:
undetectable		 1rs6B-3d0qA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 3d0q PROTEIN CALG3
(Micromonospora
echinospora) 		3 / 3 ASP A  81
GLU A 183
ARG A 320
 None
 0.78A 1wopA-3d0qA:
undetectable		 1wopA-3d0qA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3d0q PROTEIN CALG3
(Micromonospora
echinospora) 		4 / 6 ARG A  23
GLY A  26
ALA A  25
HIS A  -2
 None
 0.95A 1wrqA-3d0qA:
undetectable		 1wrqA-3d0qA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3d0q PROTEIN CALG3
(Micromonospora
echinospora) 		4 / 6 ARG A  23
GLY A  26
ALA A  25
HIS A  -2
 None
 0.94A 1wrqB-3d0qA:
undetectable		 1wrqB-3d0qA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_E_9CRE1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3d0q PROTEIN CALG3
(Micromonospora
echinospora) 		5 / 12 ILE A 233
ALA A 236
ALA A 237
ALA A 334
LEU A 246
 None
 0.94A 1xdkE-3d0qA:
undetectable		 1xdkE-3d0qA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		 3d0q PROTEIN CALG3
(Micromonospora
echinospora) 		5 / 12 ILE A 233
ALA A 236
ALA A 237
ALA A 334
LEU A 246
 None
 0.93A 1xiuA-3d0qA:
undetectable		 1xiuA-3d0qA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_A_9CRA801_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3d0q PROTEIN CALG3
(Micromonospora
echinospora) 		5 / 12 ILE A 233
ALA A 236
ALA A 237
ALA A 334
LEU A 246
 None
 0.94A 1xlsA-3d0qA:
undetectable		 1xlsA-3d0qA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3d0q PROTEIN CALG3
(Micromonospora
echinospora) 		5 / 12 ILE A 233
ALA A 236
ALA A 237
ALA A 334
LEU A 246
 None
 0.95A 1xlsB-3d0qA:
undetectable		 1xlsB-3d0qA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_C_9CRC803_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3d0q PROTEIN CALG3
(Micromonospora
echinospora) 		5 / 12 ILE A 233
ALA A 236
ALA A 237
ALA A 334
LEU A 246
 None
 0.94A 1xlsC-3d0qA:
undetectable		 1xlsC-3d0qA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3d0q PROTEIN CALG3
(Micromonospora
echinospora) 		5 / 12 ILE A 233
ALA A 236
ALA A 237
ALA A 334
LEU A 246
 None
 0.95A 1xlsD-3d0qA:
undetectable		 1xlsD-3d0qA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3d0q PROTEIN CALG3
(Micromonospora
echinospora) 		4 / 5 GLY A  86
GLN A  88
TRP A  85
VAL A  74
 None
 1.20A 1zzqB-3d0qA:
undetectable		 1zzqB-3d0qA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3d0q PROTEIN CALG3
(Micromonospora
echinospora) 		4 / 5 GLY A  86
GLN A  88
TRP A  85
VAL A  74
 None
 1.24A 1zzuA-3d0qA:
undetectable		 1zzuA-3d0qA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3d0q PROTEIN CALG3
(Micromonospora
echinospora) 		4 / 5 GLY A  86
GLN A  88
TRP A  85
VAL A  74
 None
 1.21A 1zzuB-3d0qA:
undetectable		 1zzuB-3d0qA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 3d0q PROTEIN CALG3
(Micromonospora
echinospora) 		5 / 12 PHE A 174
MET A 291
ILE A 294
ARG A 321
GLN A 311
 None
 1.34A 2rctA-3d0qA:
undetectable		 2rctA-3d0qA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)		 3d0q PROTEIN CALG3
(Micromonospora
echinospora) 		3 / 3 TRP A 191
GLN A 300
TRP A 268
 None
 1.14A 2vqyA-3d0qA:
undetectable		 2vqyA-3d0qA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3d0q PROTEIN CALG3
(Micromonospora
echinospora) 		5 / 12 ILE A 215
ALA A 247
ASN A 262
LEU A 248
VAL A 332
 None
 1.11A 3dzuA-3d0qA:
undetectable		 3dzuA-3d0qA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 3d0q PROTEIN CALG3
(Micromonospora
echinospora) 		5 / 10 ILE A 341
ALA A 236
ILE A 215
VAL A 282
VAL A 213
 None
 1.10A 3me6A-3d0qA:
undetectable		 3me6A-3d0qA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_1
(PROTEASE)		 3d0q PROTEIN CALG3
(Micromonospora
echinospora) 		5 / 9 LEU A 246
ALA A 237
VAL A 282
LEU A 301
ILE A 215
 None
 1.02A 3wsjA-3d0qA:
undetectable		 3wsjA-3d0qA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 3d0q PROTEIN CALG3
(Micromonospora
echinospora) 		4 / 8 LEU A 259
ILE A 234
GLY A 228
ILE A 227
 None
 0.90A 3wxoA-3d0qA:
undetectable		 3wxoA-3d0qA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		 3d0q PROTEIN CALG3
(Micromonospora
echinospora) 		4 / 7 LEU A 271
ALA A 214
VAL A 213
ALA A 296
 None
 0.70A 4g77A-3d0qA:
undetectable		 4g77A-3d0qA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3d0q PROTEIN CALG3
(Micromonospora
echinospora) 		5 / 12 VAL A 130
VAL A 371
ALA A 124
LEU A  18
VAL A 168
 None
 1.28A 4ib4A-3d0qA:
undetectable		 4ib4A-3d0qA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3d0q PROTEIN CALG3
(Micromonospora
echinospora) 		4 / 4 GLY A  86
GLN A  88
TRP A  85
VAL A  74
 None
 1.23A 4kcnB-3d0qA:
0.0		 4kcnB-3d0qA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3d0q PROTEIN CALG3
(Micromonospora
echinospora) 		5 / 12 VAL A 130
VAL A 371
ALA A 124
LEU A  18
VAL A 168
 None
 1.30A 4nc3A-3d0qA:
undetectable		 4nc3A-3d0qA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 3d0q PROTEIN CALG3
(Micromonospora
echinospora) 		4 / 8 LEU A 360
THR A 362
PRO A 363
VAL A 192
 None
 1.02A 4qknA-3d0qA:
undetectable		 4qknA-3d0qA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 3d0q PROTEIN CALG3
(Micromonospora
echinospora) 		5 / 12 VAL A  33
GLU A  35
LEU A  45
ALA A  40
GLY A  10
 None
 1.20A 5m5cB-3d0qA:
2.1		 5m5cB-3d0qA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 3d0q PROTEIN CALG3
(Micromonospora
echinospora) 		5 / 10 VAL A  33
GLU A  35
LEU A  45
ALA A  40
GLY A  10
 None
 1.17A 5m5cE-3d0qA:
2.0		 5m5cE-3d0qA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_A_9CRA503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3d0q PROTEIN CALG3
(Micromonospora
echinospora) 		5 / 12 ILE A 233
ALA A 236
ALA A 237
ALA A 334
LEU A 246
 None
 0.85A 5uanA-3d0qA:
undetectable		 5uanA-3d0qA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3d0q PROTEIN CALG3
(Micromonospora
echinospora) 		4 / 5 GLY A  86
GLN A  88
TRP A  85
VAL A  74
 None
 1.22A 5vunA-3d0qA:
undetectable		 5vunA-3d0qA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3d0q PROTEIN CALG3
(Micromonospora
echinospora) 		4 / 4 GLY A  86
GLN A  88
TRP A  85
VAL A  74
 None
 1.20A 5vunB-3d0qA:
0.0		 5vunB-3d0qA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3d0q PROTEIN CALG3
(Micromonospora
echinospora) 		4 / 4 GLY A  86
GLN A  88
TRP A  85
VAL A  74
 None
 1.22A 5vuoA-3d0qA:
0.0		 5vuoA-3d0qA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3d0q PROTEIN CALG3
(Micromonospora
echinospora) 		4 / 8 VAL A 213
GLN A 300
GLY A 324
LEU A 325
 None
 0.87A 5w3jB-3d0qA:
4.0		 5w3jB-3d0qA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 3d0q PROTEIN CALG3
(Micromonospora
echinospora) 		5 / 12 ALA A 303
PRO A 304
GLY A 285
LEU A 256
LEU A 246
 None
 1.15A 5wwsA-3d0qA:
3.6		 5wwsA-3d0qA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3d0q PROTEIN CALG3
(Micromonospora
echinospora) 		5 / 12 ILE A 233
ALA A 236
ALA A 237
ALA A 334
LEU A 246
 None
 0.88A 6a5zL-3d0qA:
undetectable		 6a5zL-3d0qA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3d0q PROTEIN CALG3
(Micromonospora
echinospora) 		4 / 4 GLY A  86
GLN A  88
TRP A  85
VAL A  74
 None
 1.21A 6auuB-3d0qA:
0.0		 6auuB-3d0qA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 3d0q PROTEIN CALG3
(Micromonospora
echinospora) 		5 / 11 ILE A 323
HIS A 283
ALA A 314
GLY A 287
ALA A 293
 None
 1.25A 6ieyA-3d0qA:
5.4
6ieyB-3d0qA:
4.2		 6ieyA-3d0qA:
24.24
6ieyB-3d0qA:
24.24