SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3d1c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 3d1c FLAVIN-CONTAINING
PUTATIVE
MONOOXYGENASE
(Staphylococcus
aureus) 		5 / 12 ILE A 157
ALA A 180
PHE A 163
PRO A 260
ILE A 152
 SO4  A 370 (-4.7A)
None
SO4  A 370 ( 4.3A)
None
None
 1.04A 1cd2A-3d1cA:
undetectable		 1cd2A-3d1cA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 3d1c FLAVIN-CONTAINING
PUTATIVE
MONOOXYGENASE
(Staphylococcus
aureus) 		5 / 11 ILE A 157
ALA A 180
PHE A 163
PRO A 260
ILE A 152
 SO4  A 370 (-4.7A)
None
SO4  A 370 ( 4.3A)
None
None
 1.07A 1dg5A-3d1cA:
undetectable		 1dg5A-3d1cA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 3d1c FLAVIN-CONTAINING
PUTATIVE
MONOOXYGENASE
(Staphylococcus
aureus) 		5 / 11 ILE A 157
ALA A 180
PHE A 163
PRO A 260
ILE A 152
 SO4  A 370 (-4.7A)
None
SO4  A 370 ( 4.3A)
None
None
 1.02A 1dyrA-3d1cA:
undetectable		 1dyrA-3d1cA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E71_M_ASCM995_0
(MYROSINASE MA1)		 3d1c FLAVIN-CONTAINING
PUTATIVE
MONOOXYGENASE
(Staphylococcus
aureus) 		4 / 7 ILE A  27
TYR A 133
PHE A 135
PHE A 303
 None
 1.22A 1e71M-3d1cA:
undetectable		 1e71M-3d1cA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E72_M_ASCM995_0
(MYROSINASE MA1)		 3d1c FLAVIN-CONTAINING
PUTATIVE
MONOOXYGENASE
(Staphylococcus
aureus) 		4 / 7 ILE A  27
TYR A 133
PHE A 135
PHE A 303
 None
 1.19A 1e72M-3d1cA:
undetectable		 1e72M-3d1cA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 3d1c FLAVIN-CONTAINING
PUTATIVE
MONOOXYGENASE
(Staphylococcus
aureus) 		3 / 3 ARG A 218
TYR A 182
LYS A 186
 None
 0.35A 1uujB-3d1cA:
undetectable		 1uujB-3d1cA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)		 3d1c FLAVIN-CONTAINING
PUTATIVE
MONOOXYGENASE
(Staphylococcus
aureus) 		5 / 12 GLY A  12
GLY A  39
THR A 138
ALA A 137
ALA A  13
 FAD  A 500 (-3.5A)
None
FAD  A 500 (-4.1A)
None
FAD  A 500 (-3.5A)
 1.01A 2gluB-3d1cA:
undetectable		 2gluB-3d1cA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 3d1c FLAVIN-CONTAINING
PUTATIVE
MONOOXYGENASE
(Staphylococcus
aureus) 		3 / 3 ASN A  59
TYR A  92
SER A  55
 None
 0.80A 2gvcB-3d1cA:
15.7		 2gvcB-3d1cA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 3d1c FLAVIN-CONTAINING
PUTATIVE
MONOOXYGENASE
(Staphylococcus
aureus) 		3 / 3 ASN A  59
TYR A  92
SER A  55
 None
 0.82A 2gvcE-3d1cA:
23.3		 2gvcE-3d1cA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_1
(PROTEASE)		 3d1c FLAVIN-CONTAINING
PUTATIVE
MONOOXYGENASE
(Staphylococcus
aureus) 		5 / 11 LEU A 280
GLY A  10
ILE A   8
ILE A 113
ILE A 276
 None
FAD  A 500 (-3.3A)
None
None
None
 1.12A 3ebzA-3d1cA:
undetectable		 3ebzA-3d1cA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3d1c FLAVIN-CONTAINING
PUTATIVE
MONOOXYGENASE
(Staphylococcus
aureus) 		5 / 12 LEU A  93
TYR A  89
SER A  70
PHE A 322
PHE A 326
 None
None
None
FAD  A 500 ( 4.8A)
None
 1.47A 3r43A-3d1cA:
undetectable		 3r43A-3d1cA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6I_A_JMSA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3d1c FLAVIN-CONTAINING
PUTATIVE
MONOOXYGENASE
(Staphylococcus
aureus) 		5 / 12 LEU A  93
TYR A  89
SER A  70
PHE A 322
PHE A 326
 None
None
None
FAD  A 500 ( 4.8A)
None
 1.49A 3r6iA-3d1cA:
undetectable		 3r6iA-3d1cA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R7M_A_SUZA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3d1c FLAVIN-CONTAINING
PUTATIVE
MONOOXYGENASE
(Staphylococcus
aureus) 		5 / 10 LEU A  93
TYR A  89
SER A  70
PHE A 322
PHE A 326
 None
None
None
FAD  A 500 ( 4.8A)
None
 1.45A 3r7mA-3d1cA:
undetectable		 3r7mA-3d1cA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_1
(PROTEASE)		 3d1c FLAVIN-CONTAINING
PUTATIVE
MONOOXYGENASE
(Staphylococcus
aureus) 		5 / 9 ALA A   7
ILE A 113
VAL A 136
GLY A  10
ILE A 122
 None
None
None
FAD  A 500 (-3.3A)
None
 0.99A 3s43A-3d1cA:
undetectable		 3s43A-3d1cA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3d1c FLAVIN-CONTAINING
PUTATIVE
MONOOXYGENASE
(Staphylococcus
aureus) 		5 / 12 ALA A  13
TYR A 100
TYR A  89
GLY A  12
ILE A  16
 FAD  A 500 (-3.5A)
None
None
FAD  A 500 (-3.5A)
None
 1.37A 3vwqA-3d1cA:
undetectable		 3vwqA-3d1cA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3d1c FLAVIN-CONTAINING
PUTATIVE
MONOOXYGENASE
(Staphylococcus
aureus) 		5 / 12 HIS A 153
ASP A 140
GLY A 268
LEU A 316
GLY A 306
 None
UNL  A 501 ( 4.7A)
UNL  A 501 ( 4.0A)
None
FAD  A 500 (-3.5A)
 0.94A 4blvB-3d1cA:
undetectable		 4blvB-3d1cA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3d1c FLAVIN-CONTAINING
PUTATIVE
MONOOXYGENASE
(Staphylococcus
aureus) 		3 / 3 ARG A  50
TRP A  45
GLY A  86
 None
FAD  A 500 (-4.1A)
None
 0.93A 4e7cA-3d1cA:
0.5		 4e7cA-3d1cA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 3d1c FLAVIN-CONTAINING
PUTATIVE
MONOOXYGENASE
(Staphylococcus
aureus) 		5 / 10 ILE A 157
ALA A 180
PHE A 163
PRO A 260
ILE A 152
 SO4  A 370 (-4.7A)
None
SO4  A 370 ( 4.3A)
None
None
 0.98A 4g8zX-3d1cA:
undetectable		 4g8zX-3d1cA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOS_A_4KOA201_1
(UNCHARACTERIZED
PROTEIN)		 3d1c FLAVIN-CONTAINING
PUTATIVE
MONOOXYGENASE
(Staphylococcus
aureus) 		5 / 12 PRO A  75
ASN A  59
ILE A  20
TYR A 100
LEU A  93
 None
 1.23A 4kosA-3d1cA:
undetectable		 4kosA-3d1cA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3d1c FLAVIN-CONTAINING
PUTATIVE
MONOOXYGENASE
(Staphylococcus
aureus) 		4 / 7 TYR A 129
VAL A 110
ILE A 113
ILE A 134
 SO4  A 371 (-4.7A)
FAD  A 500 ( 3.9A)
None
None
 0.88A 4lv9A-3d1cA:
undetectable		 4lv9A-3d1cA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3d1c FLAVIN-CONTAINING
PUTATIVE
MONOOXYGENASE
(Staphylococcus
aureus) 		4 / 7 TYR A 129
VAL A 110
ILE A 113
ILE A 134
 SO4  A 371 (-4.7A)
FAD  A 500 ( 3.9A)
None
None
 0.89A 4lv9B-3d1cA:
undetectable		 4lv9B-3d1cA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 3d1c FLAVIN-CONTAINING
PUTATIVE
MONOOXYGENASE
(Staphylococcus
aureus) 		5 / 9 ALA A 266
ILE A 152
GLY A 151
ILE A 240
ILE A 191
 UNL  A 501 ( 4.7A)
None
None
None
None
 1.13A 4nptA-3d1cA:
undetectable		 4nptA-3d1cA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3d1c FLAVIN-CONTAINING
PUTATIVE
MONOOXYGENASE
(Staphylococcus
aureus) 		4 / 8 ILE A  52
LEU A 184
LEU A 219
ILE A 229
 FAD  A 500 ( 4.0A)
None
None
None
 0.70A 4r38A-3d1cA:
undetectable		 4r38A-3d1cA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_A_ADNA401_1
(ADENOSINE KINASE)		 3d1c FLAVIN-CONTAINING
PUTATIVE
MONOOXYGENASE
(Staphylococcus
aureus) 		6 / 12 THR A 128
ILE A 302
ALA A   7
HIS A 130
ALA A 131
ILE A 134
 None
 1.37A 5kb6A-3d1cA:
undetectable		 5kb6A-3d1cA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 3d1c FLAVIN-CONTAINING
PUTATIVE
MONOOXYGENASE
(Staphylococcus
aureus) 		4 / 7 TRP A  45
TYR A 141
ASP A 179
TYR A 182
 FAD  A 500 (-4.1A)
FAD  A 500 (-4.7A)
None
None
 1.10A 5vlmG-3d1cA:
undetectable		 5vlmG-3d1cA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 3d1c FLAVIN-CONTAINING
PUTATIVE
MONOOXYGENASE
(Staphylococcus
aureus) 		3 / 3 PHE A 269
ASP A 270
LYS A 145
 UNL  A 501 (-4.4A)
None
None
 0.85A 6awtD-3d1cA:
undetectable		 6awtD-3d1cA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 3d1c FLAVIN-CONTAINING
PUTATIVE
MONOOXYGENASE
(Staphylococcus
aureus) 		5 / 12 LEU A 193
VAL A 169
THR A 259
PHE A 251
VAL A 237
 None
 1.43A 6drxA-3d1cA:
undetectable		 6drxA-3d1cA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 3d1c FLAVIN-CONTAINING
PUTATIVE
MONOOXYGENASE
(Staphylococcus
aureus) 		4 / 7 ILE A  20
GLU A 101
HIS A  99
VAL A  96
 None
 1.06A 6j20A-3d1cA:
0.0		 6j20A-3d1cA:
20.37