SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3d1j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A 326
ALA A 296
ALA A 367
LEU A 261
TYR A 265
 None
 1.20A 1cbrA-3d1jA:
undetectable		 1cbrA-3d1jA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A 326
ALA A 296
ALA A 367
LEU A 261
TYR A 265
 None
 1.20A 1cbrB-3d1jA:
undetectable		 1cbrB-3d1jA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		3 / 3 ASP A 105
LEU A 112
LEU A 108
 None
 0.66A 1ikeA-3d1jA:
undetectable		 1ikeA-3d1jA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA6_0
(MINI-GRAMICIDIN A)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		3 / 3 ALA A 121
VAL A 116
TRP A 115
 None
 0.79A 1kqeA-3d1jA:
undetectable
1kqeE-3d1jA:
undetectable		 1kqeA-3d1jA:
6.49
1kqeE-3d1jA:
6.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB6_0
(MINI-GRAMICIDIN A)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		3 / 3 ALA A 121
VAL A 116
TRP A 115
 None
 0.76A 1kqeB-3d1jA:
undetectable
1kqeD-3d1jA:
undetectable		 1kqeB-3d1jA:
6.49
1kqeD-3d1jA:
6.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_D_DVAD6_0
(MINI-GRAMICIDIN A)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		3 / 3 TRP A 115
ALA A 121
VAL A 116
 None
 0.78A 1kqeB-3d1jA:
undetectable
1kqeD-3d1jA:
undetectable		 1kqeB-3d1jA:
6.49
1kqeD-3d1jA:
6.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_E_DVAE6_0
(MINI-GRAMICIDIN A)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		3 / 3 TRP A 115
ALA A 121
VAL A 116
 None
 0.76A 1kqeA-3d1jA:
undetectable
1kqeE-3d1jA:
undetectable		 1kqeA-3d1jA:
6.49
1kqeE-3d1jA:
6.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q97_B_ADNB486_1
(SR PROTEIN KINASE)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		4 / 4 VAL A 349
ALA A 341
LEU A 311
PHE A 338
 None
 1.22A 1q97B-3d1jA:
0.4		 1q97B-3d1jA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG1_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		3 / 3 TRP A 442
VAL A 292
PRO A 293
 None
 0.84A 1rg1A-3d1jA:
undetectable		 1rg1A-3d1jA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH0_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		3 / 3 TRP A 442
VAL A 292
PRO A 293
 None
 0.84A 1rh0A-3d1jA:
undetectable		 1rh0A-3d1jA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_G_BEZG3385_0
(CES1 PROTEIN)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		3 / 3 SER A 303
VAL A 333
LEU A 334
 None
 0.74A 1yajG-3d1jA:
undetectable		 1yajG-3d1jA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		4 / 5 LEU A  81
LEU A  41
LEU A  14
LEU A  13
 None
 1.02A 2ab2B-3d1jA:
undetectable		 2ab2B-3d1jA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		4 / 8 SER A 156
PHE A 158
LEU A 198
LEU A 232
 None
 0.87A 2bfpA-3d1jA:
undetectable		 2bfpA-3d1jA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		4 / 8 SER A 156
PHE A 158
LEU A 198
LEU A 232
 None
 0.90A 2bfpB-3d1jA:
undetectable		 2bfpB-3d1jA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		4 / 8 SER A 156
PHE A 158
LEU A 198
LEU A 232
 None
 0.91A 2bfpC-3d1jA:
undetectable		 2bfpC-3d1jA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		4 / 8 SER A 156
PHE A 158
LEU A 198
LEU A 232
 None
 0.90A 2bfpD-3d1jA:
undetectable		 2bfpD-3d1jA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A 318
GLY A 350
TYR A 345
ALA A 325
ALA A 296
 None
 1.10A 2br4F-3d1jA:
2.2		 2br4F-3d1jA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_B_ADNB1301_1
(SUGAR KINASE MJ0406)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		4 / 7 ALA A 402
ASP A 403
GLY A 400
GLY A 399
 None
 0.75A 2c49B-3d1jA:
8.1		 2c49B-3d1jA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A   4
VAL A   6
LEU A 113
ILE A  82
MET A 120
 None
 1.03A 2gj5A-3d1jA:
undetectable		 2gj5A-3d1jA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A 326
LEU A 311
ILE A 435
GLY A 316
LEU A 318
 None
 1.04A 2j7xA-3d1jA:
undetectable		 2j7xA-3d1jA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		5 / 12 ALA A 118
ASP A 206
GLY A 201
LEU A 198
LEU A 147
 None
 1.34A 2nv4A-3d1jA:
undetectable		 2nv4A-3d1jA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		5 / 12 ALA A 118
ASP A 206
GLY A 201
LEU A 198
LEU A 147
 None
 1.33A 2nv4B-3d1jA:
undetectable		 2nv4B-3d1jA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		5 / 12 GLY A 247
HIS A 134
LEU A  19
HIS A   5
TYR A 473
 None
 1.38A 2prgA-3d1jA:
0.0		 2prgA-3d1jA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		5 / 10 THR A 398
LEU A 371
VAL A 310
GLY A 306
ARG A 396
 None
 1.10A 2wd9C-3d1jA:
4.3		 2wd9C-3d1jA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		5 / 11 THR A 391
ILE A 370
GLY A 386
TYR A 385
GLY A 365
 None
 1.00A 2y7kA-3d1jA:
undetectable		 2y7kA-3d1jA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		5 / 12 THR A 391
ILE A 370
GLY A 386
TYR A 385
GLY A 365
 None
 0.95A 2y7kC-3d1jA:
undetectable		 2y7kC-3d1jA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		5 / 12 THR A 391
ILE A 370
GLY A 386
TYR A 385
GLY A 365
 None
 0.95A 2y7kD-3d1jA:
undetectable		 2y7kD-3d1jA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		5 / 10 THR A 391
ILE A 370
GLY A 386
TYR A 385
GLY A 365
 None
 0.93A 2y7pA-3d1jA:
undetectable		 2y7pA-3d1jA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_A_SALA1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		5 / 9 THR A 391
ILE A 370
GLY A 386
TYR A 385
GLY A 365
 None
 0.86A 2y7wA-3d1jA:
undetectable		 2y7wA-3d1jA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		3 / 3 ARG A  38
ASP A 131
ASP A  36
 None
 0.86A 3jb3A-3d1jA:
undetectable		 3jb3A-3d1jA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S38_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		3 / 3 HIS A 134
HIS A 136
HIS A   5
 None
 0.78A 3s38A-3d1jA:
undetectable		 3s38A-3d1jA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S39_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		3 / 3 HIS A 134
HIS A 136
HIS A   5
 None
 0.78A 3s39A-3d1jA:
undetectable		 3s39A-3d1jA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3C_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		3 / 3 HIS A 134
HIS A 136
HIS A   5
 None
 0.78A 3s3cA-3d1jA:
undetectable		 3s3cA-3d1jA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_B_017B202_1
(PROTEASE)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		4 / 7 TRP A 128
PRO A 130
ARG A  38
PRO A  27
 None
 1.33A 3ucbB-3d1jA:
undetectable		 3ucbB-3d1jA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		5 / 10 ALA A  54
LEU A  13
LEU A  81
ASP A  83
ILE A  47
 None
 1.14A 3wdmD-3d1jA:
4.3		 3wdmD-3d1jA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_2
(ADENOSINE KINASE)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		4 / 4 LEU A 318
ILE A 435
GLY A 321
PHE A 295
 None
 1.02A 4dc3A-3d1jA:
6.4		 4dc3A-3d1jA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		5 / 12 GLY A  18
GLY A  17
LEU A 245
ASP A 403
GLY A 400
 None
 1.03A 4fzvA-3d1jA:
2.7		 4fzvA-3d1jA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A 241
GLY A 243
ALA A 210
THR A 220
ILE A 219
 None
 1.19A 4hytA-3d1jA:
4.3		 4hytA-3d1jA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A 241
GLY A 243
ALA A 210
THR A 220
ILE A 219
 None
 1.19A 4hytC-3d1jA:
1.8		 4hytC-3d1jA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		5 / 12 GLY A 227
ALA A 225
TYR A 215
LEU A 202
ASN A 162
 None
 1.02A 4pb1A-3d1jA:
undetectable		 4pb1A-3d1jA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD5_A_GEOA501_1
(NUPC FAMILY PROTEIN)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		5 / 12 GLY A 227
ALA A 225
TYR A 215
LEU A 202
ASN A 162
 None
 1.01A 4pd5A-3d1jA:
undetectable		 4pd5A-3d1jA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		5 / 11 LEU A 326
LEU A 311
ILE A 435
GLY A 316
LEU A 318
 None
 1.01A 4pxmB-3d1jA:
undetectable		 4pxmB-3d1jA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		4 / 8 ALA A 200
ALA A 135
SER A 156
ALA A 145
 None
 0.77A 4twdF-3d1jA:
undetectable
4twdG-3d1jA:
undetectable
4twdH-3d1jA:
undetectable
4twdI-3d1jA:
undetectable
4twdJ-3d1jA:
undetectable		 4twdF-3d1jA:
21.69
4twdG-3d1jA:
21.69
4twdH-3d1jA:
21.69
4twdI-3d1jA:
21.69
4twdJ-3d1jA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		4 / 7 ARG A  38
GLN A   2
PRO A 130
ASP A 125
 None
 1.04A 4w5oA-3d1jA:
3.6		 4w5oA-3d1jA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		5 / 11 LEU A 179
PHE A 169
GLY A 114
LEU A 113
ALA A 200
 None
 1.08A 4wnuA-3d1jA:
undetectable		 4wnuA-3d1jA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		5 / 11 LEU A 179
PHE A 169
GLY A 114
LEU A 113
ALA A 200
 None
 1.21A 4wnuC-3d1jA:
undetectable		 4wnuC-3d1jA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		4 / 7 ARG A  38
GLN A   2
PRO A 130
ASP A 125
 None
 1.05A 4z4eA-3d1jA:
3.1		 4z4eA-3d1jA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		4 / 7 ARG A  38
GLN A   2
PRO A 130
ASP A 125
 None
 1.04A 4z4gA-3d1jA:
3.3		 4z4gA-3d1jA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		4 / 5 ARG A  38
GLN A   2
PRO A 130
ASP A 125
 None
 1.06A 4z4hA-3d1jA:
3.7		 4z4hA-3d1jA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		4 / 5 ALA A 143
TYR A 146
HIS A  66
PHE A  63
 None
 1.35A 4ze2A-3d1jA:
undetectable		 4ze2A-3d1jA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A 326
LEU A 311
ILE A 435
GLY A 316
LEU A 318
 None
 1.10A 5gtrA-3d1jA:
undetectable		 5gtrA-3d1jA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		4 / 5 ILE A  47
LEU A  19
HIS A   5
VAL A  39
 None
 1.22A 5jmnB-3d1jA:
undetectable		 5jmnB-3d1jA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		4 / 8 ILE A  47
ALA A  20
ILE A  23
GLU A   9
 None
 0.70A 5mvmA-3d1jA:
undetectable
5mvmB-3d1jA:
undetectable		 5mvmA-3d1jA:
9.73
5mvmB-3d1jA:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		5 / 10 ARG A 150
ALA A 118
GLY A 123
ILE A  47
LEU A  13
 None
 1.22A 5oy01-3d1jA:
undetectable
5oy07-3d1jA:
undetectable		 5oy01-3d1jA:
11.83
5oy07-3d1jA:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A 326
LEU A 311
ILE A 435
LEU A 431
LEU A 318
 None
 1.16A 5toaB-3d1jA:
undetectable		 5toaB-3d1jA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VNC_C_GCSC801_1
(GLYCOGEN [STARCH]
SYNTHASE ISOFORM 2)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		5 / 10 HIS A 161
VAL A 211
ASN A 246
GLU A 377
GLY A 380
 None
 0.99A 5vncC-3d1jA:
16.7		 5vncC-3d1jA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VNC_C_GCSC801_1
(GLYCOGEN [STARCH]
SYNTHASE ISOFORM 2)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		5 / 10 VAL A 211
ASN A 246
GLU A 377
PRO A 378
GLY A 380
 None
 1.12A 5vncC-3d1jA:
16.7		 5vncC-3d1jA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VNC_C_GCSC801_1
(GLYCOGEN [STARCH]
SYNTHASE ISOFORM 2)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		5 / 10 VAL A 211
ASN A 246
LYS A 305
GLU A 377
GLY A 380
 None
 0.84A 5vncC-3d1jA:
16.7		 5vncC-3d1jA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		5 / 12 ILE A  23
LEU A  41
GLY A 141
ALA A 140
LEU A 113
 None
 1.20A 5zwrA-3d1jA:
undetectable		 5zwrA-3d1jA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		5 / 12 GLU A 357
LEU A 307
LEU A 326
LEU A 301
THR A 302
 None
 0.84A 6b0cD-3d1jA:
3.1		 6b0cD-3d1jA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		5 / 10 VAL A 372
GLY A 386
LEU A 387
GLN A 383
VAL A 369
 None
 1.14A 6czmE-3d1jA:
1.5
6czmF-3d1jA:
undetectable		 6czmE-3d1jA:
23.54
6czmF-3d1jA:
23.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GNE_A_ACRA602_1
(-)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		6 / 12 GLY A  17
GLY A  18
VAL A  22
ASP A 137
VAL A 211
ASN A 246
 None
 0.68A 6gneA-3d1jA:
43.2		 6gneA-3d1jA:
31.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GNE_B_ACRB602_1
(-)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		7 / 12 GLU A   9
GLY A  17
GLY A  18
VAL A  22
ASP A 137
VAL A 211
ASN A 246
 None
 0.75A 6gneB-3d1jA:
31.3		 6gneB-3d1jA:
31.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GNE_B_ACRB602_2
(-)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		4 / 8 TRP A 138
HIS A 161
TYR A 165
GLU A 377
 None
 0.99A 6gneB-3d1jA:
31.3		 6gneB-3d1jA:
31.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GNF_A_QPSA602_1
(-)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		5 / 12 VAL A  22
ASP A 137
HIS A 139
ASN A 246
GLY A 380
 None
 0.89A 6gnfA-3d1jA:
41.2		 6gnfA-3d1jA:
30.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GNF_A_QPSA602_2
(-)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		6 / 9 THR A  16
GLY A  17
GLY A  18
TYR A  95
HIS A 161
VAL A 211
 None
 0.75A 6gnfA-3d1jA:
41.2		 6gnfA-3d1jA:
30.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GNF_A_QPSA602_2
(-)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		6 / 9 THR A  16
GLY A  18
TYR A  95
TRP A 138
HIS A 161
VAL A 211
 None
 0.71A 6gnfA-3d1jA:
41.2		 6gnfA-3d1jA:
30.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GNF_C_QPSC602_1
(-)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		7 / 10 THR A  16
GLY A  18
LEU A  19
TYR A  95
TRP A 138
HIS A 161
VAL A 211
 None
 0.73A 6gnfC-3d1jA:
41.6		 6gnfC-3d1jA:
30.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GNF_C_QPSC602_2
(-)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		5 / 12 VAL A  22
ASP A 137
HIS A 139
ASN A 246
GLY A 380
 None
 0.89A 6gnfC-3d1jA:
41.7		 6gnfC-3d1jA:
30.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		5 / 12 THR A  16
ASP A 137
HIS A 139
ASN A 162
ASN A 246
 None
 1.00A 6gngA-3d1jA:
40.8		 6gngA-3d1jA:
29.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		7 / 12 THR A  16
GLY A  17
LEU A  19
VAL A  22
ASP A 137
HIS A 139
ASN A 246
 None
 0.77A 6gngA-3d1jA:
40.8		 6gngA-3d1jA:
29.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		7 / 12 GLU A   9
GLY A  18
TYR A  95
TRP A 138
HIS A 161
TYR A 165
VAL A 211
 None
 0.75A 6gngA-3d1jA:
40.8		 6gngA-3d1jA:
29.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		5 / 12 GLY A  18
TRP A 138
TYR A 165
VAL A 211
PRO A 378
 None
 0.94A 6gngA-3d1jA:
40.8		 6gngA-3d1jA:
29.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		5 / 12 TRP A 138
HIS A 161
TYR A 165
VAL A 211
GLY A 380
 None
 0.92A 6gngA-3d1jA:
40.8		 6gngA-3d1jA:
29.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		5 / 12 TRP A 138
TYR A 165
VAL A 211
PRO A 378
GLY A 380
 None
 1.24A 6gngA-3d1jA:
40.8		 6gngA-3d1jA:
29.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		7 / 12 THR A  16
VAL A  22
TYR A  95
TRP A 138
HIS A 161
TYR A 165
VAL A 211
 None
 0.71A 6gngB-3d1jA:
40.8		 6gngB-3d1jA:
29.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		5 / 12 VAL A  22
HIS A 161
VAL A 211
GLU A 377
GLY A 380
 None
 0.93A 6gngB-3d1jA:
40.8		 6gngB-3d1jA:
29.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		6 / 12 VAL A  22
TRP A 138
HIS A 161
TYR A 165
VAL A 211
GLY A 380
 None
 1.00A 6gngB-3d1jA:
40.8		 6gngB-3d1jA:
29.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 3d1j GLYCOGEN SYNTHASE
(Escherichia
coli) 		5 / 12 GLU A   9
GLY A  17
GLY A  18
LEU A  19
HIS A 139
 None
 0.78A 6gngB-3d1jA:
40.8		 6gngB-3d1jA:
29.94