SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3d1r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX
(Escherichia
coli) 		4 / 6 LEU A  66
ILE A  49
ARG A   2
VAL A  12
 None
 1.14A 1db1A-3d1rA:
undetectable		 1db1A-3d1rA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DGM_A_ADNA375_1
(ADENOSINE KINASE)		 3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX
(Escherichia
coli) 		5 / 9 ASN A  48
ILE A  49
GLY A  73
ASN A  45
LEU A 104
 None
 1.30A 1dgmA-3d1rA:
undetectable		 1dgmA-3d1rA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX
(Escherichia
coli) 		4 / 7 ALA A 102
LEU A 104
SER A 281
THR A 283
 None
 0.37A 1dvxA-3d1rA:
undetectable		 1dvxA-3d1rA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_2
(TRANSTHYRETIN)		 3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX
(Escherichia
coli) 		4 / 7 ALA A 102
LEU A 104
SER A 281
THR A 283
 None
 0.40A 1dvxB-3d1rA:
undetectable		 1dvxB-3d1rA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX
(Escherichia
coli) 		5 / 11 LEU A 139
LEU A 233
LEU A 135
VAL A 170
ILE A 208
 None
 1.35A 1ee2A-3d1rA:
2.5		 1ee2A-3d1rA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX
(Escherichia
coli) 		5 / 11 LEU A 139
LEU A 233
LEU A 135
VAL A 170
ILE A 208
 None
 1.31A 1ee2B-3d1rA:
2.4		 1ee2B-3d1rA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX
(Escherichia
coli) 		4 / 8 ALA A 102
GLY A 293
ALA A  17
ILE A 294
 None
 0.70A 1gtnI-3d1rA:
undetectable
1gtnJ-3d1rA:
undetectable		 1gtnI-3d1rA:
15.76
1gtnJ-3d1rA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX
(Escherichia
coli) 		4 / 6 ALA A 102
LEU A 104
SER A 281
THR A 283
 None
 0.78A 1ictB-3d1rA:
undetectable		 1ictB-3d1rA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_1
(ESTROGEN RECEPTOR
BETA)		 3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX
(Escherichia
coli) 		5 / 12 THR A  13
ALA A  16
ILE A  82
ILE A  53
GLY A  56
 None
 0.91A 1qknA-3d1rA:
undetectable		 1qknA-3d1rA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX
(Escherichia
coli) 		4 / 6 ALA A 102
LEU A 104
SER A 281
THR A 283
 None
 0.52A 1tyrA-3d1rA:
undetectable		 1tyrA-3d1rA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX
(Escherichia
coli) 		4 / 6 ALA A 102
LEU A 104
SER A 281
THR A 283
 None
 0.69A 3cfqA-3d1rA:
undetectable		 3cfqA-3d1rA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)		 3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX
(Escherichia
coli) 		4 / 7 ALA A 102
LEU A 104
SER A 281
THR A 283
 None
 0.70A 3cfqA-3d1rA:
undetectable
3cfqB-3d1rA:
undetectable		 3cfqA-3d1rA:
14.97
3cfqB-3d1rA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX
(Escherichia
coli) 		4 / 6 ALA A 102
LEU A 104
SER A 281
THR A 283
 None
 0.85A 3d2tB-3d1rA:
undetectable		 3d2tB-3d1rA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_2
(PROTEASE)		 3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX
(Escherichia
coli) 		5 / 12 LEU A  66
VAL A  54
ILE A  49
VAL A  84
ILE A  53
 None
 0.84A 3pwmB-3d1rA:
undetectable		 3pwmB-3d1rA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX
(Escherichia
coli) 		4 / 7 VAL A 103
LEU A 290
MET A 197
ILE A 193
 None
 1.02A 3rfmA-3d1rA:
undetectable		 3rfmA-3d1rA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX
(Escherichia
coli) 		4 / 7 ARG A  26
ALA A 100
GLY A 293
ILE A 294
 None
 0.83A 3spkB-3d1rA:
undetectable		 3spkB-3d1rA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX
(Escherichia
coli) 		4 / 8 ASP A  50
ILE A  49
GLY A  51
SER A  15
 None
 0.87A 4acbB-3d1rA:
undetectable
4acbC-3d1rA:
undetectable		 4acbB-3d1rA:
23.73
4acbC-3d1rA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX
(Escherichia
coli) 		5 / 11 GLY A  77
ASP A  50
GLY A  75
VAL A  80
VAL A  47
 None
 1.42A 4c5lA-3d1rA:
undetectable		 4c5lA-3d1rA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX
(Escherichia
coli) 		5 / 10 GLY A  77
ASP A  50
GLY A  75
VAL A  80
VAL A  47
 None
 1.43A 4c5lC-3d1rA:
undetectable		 4c5lC-3d1rA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX
(Escherichia
coli) 		4 / 7 ALA A 102
LEU A 104
SER A 281
THR A 283
 None
 0.73A 4d7bA-3d1rA:
undetectable		 4d7bA-3d1rA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX
(Escherichia
coli) 		4 / 6 ALA A 102
LEU A 104
SER A 281
THR A 283
 None
 0.73A 4ikiB-3d1rA:
undetectable		 4ikiB-3d1rA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX
(Escherichia
coli) 		4 / 7 ALA A 102
LEU A 104
SER A 281
THR A 283
 None
 0.62A 4ikjA-3d1rA:
undetectable
4ikjB-3d1rA:
undetectable		 4ikjA-3d1rA:
16.17
4ikjB-3d1rA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX
(Escherichia
coli) 		4 / 7 ALA A 102
LEU A 104
SER A 281
THR A 283
 None
 0.69A 4ikkA-3d1rA:
undetectable
4ikkB-3d1rA:
undetectable		 4ikkA-3d1rA:
16.17
4ikkB-3d1rA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX
(Escherichia
coli) 		5 / 10 LEU A   5
LEU A 307
ARG A   2
ILE A  49
THR A 283
 None
 1.35A 4mk4A-3d1rA:
undetectable		 4mk4A-3d1rA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX
(Escherichia
coli) 		4 / 8 ILE A 124
SER A 200
LEU A 290
LEU A 306
 None
MG  A3504 (-3.9A)
None
None
 0.99A 4xtaB-3d1rA:
undetectable		 4xtaB-3d1rA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX
(Escherichia
coli) 		4 / 7 ALA A 211
ASP A 237
GLY A 249
GLU A 250
 None
 0.90A 5btgA-3d1rA:
undetectable
5btgC-3d1rA:
undetectable
5btgD-3d1rA:
undetectable		 5btgA-3d1rA:
20.74
5btgC-3d1rA:
20.74
5btgD-3d1rA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX
(Escherichia
coli) 		5 / 12 ILE A  53
ASP A  33
ALA A  17
ALA A  16
VAL A  12
 None
CA  A 337 (-2.7A)
None
None
None
 0.96A 5igjA-3d1rA:
undetectable		 5igjA-3d1rA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUO_D_PFLD402_1
(PROTON-GATED ION
CHANNEL)		 3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX
(Escherichia
coli) 		5 / 9 SER A 320
ILE A   7
THR A  13
SER A 281
THR A 283
 None
 1.43A 5muoA-3d1rA:
2.2
5muoB-3d1rA:
2.0
5muoC-3d1rA:
undetectable
5muoD-3d1rA:
undetectable
5muoE-3d1rA:
2.2		 5muoA-3d1rA:
13.10
5muoB-3d1rA:
13.10
5muoC-3d1rA:
13.10
5muoD-3d1rA:
13.10
5muoE-3d1rA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_C_SAMC301_0
(NS5)		 3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX
(Escherichia
coli) 		5 / 12 GLY A 207
GLY A 209
GLY A 214
VAL A 170
ILE A 161
 None
FBP  A3499 ( 4.0A)
None
None
None
 0.94A 5njvC-3d1rA:
undetectable		 5njvC-3d1rA:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX
(Escherichia
coli) 		5 / 11 LEU A 233
ILE A 208
GLY A 209
GLY A 210
VAL A 238
 None
None
FBP  A3499 ( 4.0A)
FBP  A3499 (-3.7A)
None
 0.84A 5twjD-3d1rA:
undetectable		 5twjD-3d1rA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX
(Escherichia
coli) 		3 / 3 LEU A 101
VAL A 189
ASP A 188
 None
None
FBP  A3499 (-2.8A)
 0.58A 5x23A-3d1rA:
undetectable		 5x23A-3d1rA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_K_BO2K301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX
(Escherichia
coli) 		5 / 11 ALA A 234
ALA A 263
GLY A 209
GLY A 210
ALA A 211
 None
None
FBP  A3499 ( 4.0A)
FBP  A3499 (-3.7A)
None
 0.85A 6hwdK-3d1rA:
undetectable
6hwdL-3d1rA:
undetectable		 6hwdK-3d1rA:
13.08
6hwdL-3d1rA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_Y_BO2Y301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX
(Escherichia
coli) 		5 / 11 ALA A 234
ALA A 263
GLY A 209
GLY A 210
ALA A 211
 None
None
FBP  A3499 ( 4.0A)
FBP  A3499 (-3.7A)
None
 0.85A 6hwdY-3d1rA:
undetectable
6hwdZ-3d1rA:
undetectable		 6hwdY-3d1rA:
13.08
6hwdZ-3d1rA:
14.29