SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3d2l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		4 / 7 LEU A 132
ALA A 239
PHE A 214
VAL A 216
 None
 0.79A 1epbA-3d2lA:
undetectable		 1epbA-3d2lA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		4 / 8 LEU A 132
ALA A 239
PHE A 214
VAL A 216
 None
 0.81A 1epbB-3d2lA:
undetectable		 1epbB-3d2lA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		5 / 12 GLY A  42
SER A  62
MET A  65
SER A 105
LEU A 109
 None
 0.93A 1kiaD-3d2lA:
22.7		 1kiaD-3d2lA:
26.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		5 / 12 GLY A  42
THR A  43
SER A  62
MET A  65
HIS A 195
 None
 1.12A 1nbiC-3d2lA:
22.1		 1nbiC-3d2lA:
26.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		5 / 12 GLY A  42
THR A  43
SER A  62
MET A  65
SER A 105
 None
 0.89A 1nbiC-3d2lA:
22.1		 1nbiC-3d2lA:
26.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		5 / 12 GLY A  42
THR A  43
SER A  62
MET A  65
HIS A 195
 None
 1.13A 1nbiD-3d2lA:
22.2		 1nbiD-3d2lA:
26.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		5 / 12 GLY A  42
THR A  43
SER A  62
MET A  65
SER A 105
 None
 0.89A 1nbiD-3d2lA:
22.2		 1nbiD-3d2lA:
26.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		5 / 12 GLY A  40
GLY A  42
ASP A  86
SER A 105
TYR A 108
 None
 1.08A 1ri4A-3d2lA:
19.2		 1ri4A-3d2lA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		5 / 12 THR A 100
ILE A 101
ASN A 107
TYR A 205
TRP A  25
 None
 1.18A 1wsvA-3d2lA:
undetectable		 1wsvA-3d2lA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		5 / 12 THR A 100
ILE A 101
ASN A 107
TYR A 205
TRP A  25
 None
 1.15A 1wsvB-3d2lA:
undetectable		 1wsvB-3d2lA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		5 / 12 LEU A  27
VAL A  23
THR A  57
GLY A  33
LEU A 125
 None
 1.08A 2cbrA-3d2lA:
undetectable		 2cbrA-3d2lA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		4 / 7 GLY A  42
TYR A  19
ASP A  60
ASP A  86
 None
 0.86A 2g72B-3d2lA:
14.7		 2g72B-3d2lA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		4 / 7 GLY A  42
ASP A  60
ASP A  86
ARG A  88
 None
 0.50A 2uyqA-3d2lA:
11.9		 2uyqA-3d2lA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		4 / 5 TYR A 205
MET A 142
PRO A 139
ASN A 107
 None
 1.28A 2wekA-3d2lA:
7.5		 2wekA-3d2lA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		4 / 6 TYR A 205
MET A 142
PRO A 139
ASN A 107
 None
 1.26A 2wekB-3d2lA:
7.8		 2wekB-3d2lA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		4 / 6 ASP A  86
LEU A  90
ASP A  60
LEU A  66
 None
 1.25A 3bj8C-3d2lA:
undetectable
3bj8D-3d2lA:
undetectable		 3bj8C-3d2lA:
20.95
3bj8D-3d2lA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		9 / 12 GLY A  42
LEU A  61
SER A  62
MET A  65
MET A  87
ARG A  88
SER A 105
TYR A 108
LEU A 109
 None
 0.81A 3bxoA-3d2lA:
26.4		 3bxoA-3d2lA:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_0
(N,N-DIMETHYLTRANSFER
ASE)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		7 / 12 GLY A  42
LEU A  61
SER A  62
MET A  65
MET A  87
ARG A  88
SER A 105
 None
 0.78A 3bxoB-3d2lA:
26.3		 3bxoB-3d2lA:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_0
(N,N-DIMETHYLTRANSFER
ASE)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		6 / 12 GLY A  42
LEU A  61
SER A  62
MET A  87
SER A 105
TYR A 108
 None
 0.68A 3bxoB-3d2lA:
26.3		 3bxoB-3d2lA:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		4 / 6 THR A 118
ILE A 101
SER A 105
LEU A 106
 None
 0.77A 3deuB-3d2lA:
undetectable		 3deuB-3d2lA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		5 / 12 TYR A  19
GLY A  40
GLY A  42
SER A  62
ASP A  86
 None
 0.53A 3dlcA-3d2lA:
16.9		 3dlcA-3d2lA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		5 / 12 GLY A  42
LEU A  61
SER A  62
MET A  87
SER A 105
 None
 0.73A 3g2oA-3d2lA:
20.0		 3g2oA-3d2lA:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		5 / 12 GLY A  42
LEU A  61
ASP A  86
MET A  87
SER A 105
 None
 0.56A 3g2oB-3d2lA:
20.6		 3g2oB-3d2lA:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		5 / 12 GLY A  40
CYH A  41
LEU A  48
VAL A  80
LYS A  72
 None
 1.25A 3g9eA-3d2lA:
undetectable		 3g9eA-3d2lA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		5 / 12 ALA A 123
GLN A 117
PHE A 119
ILE A 101
LEU A 106
 None
 1.27A 3ia4C-3d2lA:
2.3		 3ia4C-3d2lA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		3 / 3 GLY A  42
ASP A  60
ASP A  86
 None
 0.40A 3ou7C-3d2lA:
17.4		 3ou7C-3d2lA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		7 / 12 GLY A  42
LEU A  61
SER A  62
MET A  65
ASP A  86
MET A  87
SER A 105
 None
 0.69A 3pfgA-3d2lA:
26.2		 3pfgA-3d2lA:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		5 / 12 GLY A  40
GLY A  42
VAL A  59
LEU A  61
SER A 105
 None
 0.84A 4f84A-3d2lA:
18.2		 4f84A-3d2lA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		5 / 12 GLY A  40
GLY A  42
MET A  65
ASP A  86
SER A 105
 None
 0.58A 4iv0B-3d2lA:
17.8		 4iv0B-3d2lA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		6 / 12 GLY A  40
GLY A  42
ASP A  60
MET A  65
ASP A  86
LEU A 109
 None
 0.62A 4iv8A-3d2lA:
17.9		 4iv8A-3d2lA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		6 / 12 GLY A  40
GLY A  42
ASP A  60
MET A  65
ASP A  86
LEU A 109
 None
 0.66A 4iv8B-3d2lA:
17.9		 4iv8B-3d2lA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		5 / 12 GLY A  40
GLY A  42
LEU A  61
SER A  62
ASP A  86
 None
 0.61A 4krhA-3d2lA:
17.9		 4krhA-3d2lA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		5 / 12 GLY A  40
GLY A  42
MET A  65
SER A 105
LEU A 109
 None
 0.51A 4mwzA-3d2lA:
17.9		 4mwzA-3d2lA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		5 / 11 GLY A  40
ASP A  60
LEU A  61
ASP A  86
MET A  87
 None
 0.91A 4pghA-3d2lA:
16.6		 4pghA-3d2lA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		5 / 12 ASP A  38
GLY A  40
ASP A  60
ASP A  86
MET A  87
 None
 0.71A 4pghB-3d2lA:
16.5		 4pghB-3d2lA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		5 / 12 ASP A  38
GLY A  40
ASP A  60
LEU A  61
MET A  87
 None
 1.03A 4pghB-3d2lA:
16.5		 4pghB-3d2lA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		5 / 12 ASP A  38
GLY A  40
ASP A  86
MET A  87
ILE A 101
 None
 1.11A 4pghB-3d2lA:
16.5		 4pghB-3d2lA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_C_SAMC401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		5 / 11 GLY A  40
ASP A  60
ASP A  86
MET A  87
TRP A  22
 None
 1.08A 4pghC-3d2lA:
16.9		 4pghC-3d2lA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		5 / 12 GLY A  40
GLY A  42
SER A  62
MET A  65
LEU A 102
 None
 0.86A 4qdjA-3d2lA:
17.3		 4qdjA-3d2lA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		5 / 12 GLY A  40
GLY A  42
SER A  62
MET A  65
MET A  87
 None
 0.69A 4qtuB-3d2lA:
18.0		 4qtuB-3d2lA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		5 / 12 GLY A  40
GLY A  42
SER A  62
MET A  65
MET A  87
 None
 0.71A 4qtuD-3d2lA:
18.7		 4qtuD-3d2lA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		5 / 12 TYR A  54
GLU A  31
GLY A  33
LEU A 126
LEU A 132
 None
 1.24A 4wcxC-3d2lA:
2.2		 4wcxC-3d2lA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		5 / 12 TYR A  19
GLY A  40
ASP A  60
LEU A  61
SER A  62
 None
 0.71A 5dpdB-3d2lA:
16.9		 5dpdB-3d2lA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		4 / 4 ASP A  38
GLY A  42
ASP A  60
ASP A  86
 None
 0.78A 5e72A-3d2lA:
17.0		 5e72A-3d2lA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		5 / 12 GLY A  42
SER A  62
MET A  65
SER A 105
LEU A 109
 None
 0.69A 5gwxA-3d2lA:
21.6		 5gwxA-3d2lA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		5 / 12 GLY A  42
SER A  62
MET A  65
ASP A  86
ARG A  88
 None
 0.93A 5hikA-3d2lA:
21.6		 5hikA-3d2lA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		5 / 12 GLY A  42
SER A  62
MET A  65
ASP A  86
SER A 105
 None
 0.77A 5hikA-3d2lA:
21.6		 5hikA-3d2lA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		4 / 6 GLU A 193
THR A  43
TYR A  10
TYR A 108
 None
 1.35A 5lrbA-3d2lA:
2.8		 5lrbA-3d2lA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		4 / 8 THR A 194
LEU A 177
VAL A   9
TYR A  10
 None
 1.16A 5ov9B-3d2lA:
undetectable		 5ov9B-3d2lA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_0
(CARNOSINE
N-METHYLTRANSFERASE)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		5 / 12 GLY A  40
GLY A  42
SER A  62
MET A  65
CYH A 103
 None
 1.00A 5yf0A-3d2lA:
11.8		 5yf0A-3d2lA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		5 / 11 GLY A  40
GLY A  42
ASP A  60
ASP A  86
MET A  87
 None
 0.75A 6i5zD-3d2lA:
14.4		 6i5zD-3d2lA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 3d2l SAM-DEPENDENT
METHYLTRANSFERASE
(Exiguobacterium
sibiricum) 		5 / 11 GLY A  40
GLY A  42
ASP A  86
MET A  87
TRP A  22
 None
 1.26A 6i5zD-3d2lA:
14.4		 6i5zD-3d2lA:
21.20