SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3d2z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3d2z N-ACETYLMURAMOYL-L-A
LANINE AMIDASE AMID
(Escherichia
coli) 		4 / 7 ARG A 235
ALA A 249
PRO A 180
ALA A 253
 None
 1.00A 2ejfA-3d2zA:
undetectable		 2ejfA-3d2zA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		 3d2z N-ACETYLMURAMOYL-L-A
LANINE AMIDASE AMID
(Escherichia
coli) 		4 / 4 ALA A  61
VAL A  59
PHE A 122
THR A  37
 None
 1.34A 2pkkA-3d2zA:
undetectable		 2pkkA-3d2zA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3d2z N-ACETYLMURAMOYL-L-A
LANINE AMIDASE AMID
(Escherichia
coli) 		3 / 3 LYS A 144
GLU A 146
TRP A  90
 None
 1.25A 3v4tH-3d2zA:
undetectable		 3v4tH-3d2zA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3d2z N-ACETYLMURAMOYL-L-A
LANINE AMIDASE AMID
(Escherichia
coli) 		3 / 3 ASP A 161
ARG A 158
LYS A 159
 ZN  A 262 ( 2.2A)
None
ZN  A 262 ( 4.9A)
 1.03A 3wipG-3d2zA:
undetectable		 3wipG-3d2zA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3d2z N-ACETYLMURAMOYL-L-A
LANINE AMIDASE AMID
(Escherichia
coli) 		4 / 6 LYS A 135
ILE A 138
VAL A 148
LEU A  32
 None
 0.99A 4em2A-3d2zA:
undetectable		 4em2A-3d2zA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_B_MZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3d2z N-ACETYLMURAMOYL-L-A
LANINE AMIDASE AMID
(Escherichia
coli) 		5 / 10 HIS A 151
VAL A 149
VAL A  33
LEU A  96
ALA A  89
 ZN  A 262 ( 3.0A)
None
None
None
None
 1.33A 4yhaB-3d2zA:
undetectable		 4yhaB-3d2zA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 3d2z N-ACETYLMURAMOYL-L-A
LANINE AMIDASE AMID
(Escherichia
coli) 		4 / 7 VAL A 198
GLN A 248
LEU A 203
GLU A 205
 None
 0.82A 4zphA-3d2zA:
undetectable
4zphB-3d2zA:
undetectable		 4zphA-3d2zA:
18.88
4zphB-3d2zA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_F_EZLF302_1
(ALPHA-CARBONIC
ANHYDRASE)		 3d2z N-ACETYLMURAMOYL-L-A
LANINE AMIDASE AMID
(Escherichia
coli) 		4 / 8 HIS A 151
VAL A 149
VAL A  33
LEU A  96
 ZN  A 262 ( 3.0A)
None
None
None
 0.83A 5tt3F-3d2zA:
undetectable		 5tt3F-3d2zA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 3d2z N-ACETYLMURAMOYL-L-A
LANINE AMIDASE AMID
(Escherichia
coli) 		3 / 3 TYR A 212
HIS A 233
MET A 232
 None
 1.00A 6af6A-3d2zA:
undetectable		 6af6A-3d2zA:
20.10