SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3d31'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 3d31 SULFATE/MOLYBDATE
ABC TRANSPORTER,
PERMEASE PROTEIN
(Methanosarcina
acetivorans) 		5 / 12 ILE C  41
GLY C  47
PHE C  45
VAL C 246
ALA C 245
 None
 1.11A 1tlsA-3d31C:
undetectable		 1tlsA-3d31C:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 3d31 SULFATE/MOLYBDATE
ABC TRANSPORTER,
PERMEASE PROTEIN
(Methanosarcina
acetivorans) 		5 / 12 ILE C  41
GLY C  47
PHE C  45
VAL C 246
ALA C 245
 None
 1.09A 1tsnA-3d31C:
undetectable		 1tsnA-3d31C:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_B_NCAB901_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 3d31 SULFATE/MOLYBDATE
ABC TRANSPORTER,
PERMEASE PROTEIN
(Methanosarcina
acetivorans) 		4 / 5 ILE C 101
PRO C 153
PHE C 149
VAL C 103
 None
 1.28A 2hjhB-3d31C:
undetectable		 2hjhB-3d31C:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 3d31 SULFATE/MOLYBDATE
ABC TRANSPORTER,
PERMEASE PROTEIN
(Methanosarcina
acetivorans) 		5 / 12 LEU C 238
LEU C  48
GLY C  47
VAL C 246
ALA C 245
 None
 1.17A 2kceB-3d31C:
undetectable		 2kceB-3d31C:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 3d31 SULFATE/MOLYBDATE
ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		4 / 7 ASP A 159
SER A 156
GLU A 153
ASP A 152
 None
 1.25A 3bc9A-3d31A:
undetectable		 3bc9A-3d31A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 3d31 SULFATE/MOLYBDATE
ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		5 / 12 VAL A 181
ILE A 198
ALA A 191
THR A 189
ILE A 193
 None
 1.25A 3ddyA-3d31A:
2.6		 3ddyA-3d31A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 3d31 SULFATE/MOLYBDATE
ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		4 / 7 LEU A 155
GLU A 190
ASP A 187
THR A 162
 None
 1.35A 3dzgB-3d31A:
undetectable		 3dzgB-3d31A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3d31 SULFATE/MOLYBDATE
ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		5 / 9 GLY A  36
GLY A  38
ASN A  13
GLU A 153
ILE A 184
 None
 1.41A 3owxA-3d31A:
undetectable		 3owxA-3d31A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 3d31 SULFATE/MOLYBDATE
ABC TRANSPORTER,
PERMEASE PROTEIN
(Methanosarcina
acetivorans) 		5 / 12 VAL C 144
GLY C  68
ALA C  67
SER C  64
LEU C  63
 None
 1.28A 3pghA-3d31C:
1.2		 3pghA-3d31C:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 3d31 SULFATE/MOLYBDATE
ABC TRANSPORTER,
ATP-BINDING PROTEIN
SULFATE/MOLYBDATE
ABC TRANSPORTER,
PERMEASE PROTEIN
(Methanosarcina
acetivorans) 		5 / 12 LEU A 142
ALA A 137
LEU A 151
ILE A  74
LEU C 177
 None
 1.04A 3q95A-3d31A:
undetectable		 3q95A-3d31A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3d31 SULFATE/MOLYBDATE
ABC TRANSPORTER,
ATP-BINDING PROTEIN
SULFATE/MOLYBDATE
ABC TRANSPORTER,
PERMEASE PROTEIN
(Methanosarcina
acetivorans;
Methanosarcina
acetivorans) 		4 / 4 LEU C 177
GLY C 178
GLY A  96
THR A 144
 None
 0.90A 3si7A-3d31C:
undetectable		 3si7A-3d31C:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)		 3d31 SULFATE/MOLYBDATE
ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		5 / 12 ARG A 348
GLY A 244
GLY A 259
GLU A 262
ALA A 241
 None
 1.22A 3t7sA-3d31A:
undetectable		 3t7sA-3d31A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 3d31 SULFATE/MOLYBDATE
ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		5 / 12 ARG A 348
GLY A 244
GLY A 259
GLU A 262
ALA A 241
 None
 1.26A 3t7sC-3d31A:
undetectable		 3t7sC-3d31A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3d31 SULFATE/MOLYBDATE
ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		5 / 6 GLY A  36
GLY A  38
ASN A  13
GLU A 153
ILE A 184
 None
 1.48A 4fglD-3d31A:
undetectable		 4fglD-3d31A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 3d31 SULFATE/MOLYBDATE
ABC TRANSPORTER,
PERMEASE PROTEIN
(Methanosarcina
acetivorans) 		5 / 12 ILE C  41
GLY C  47
PHE C  45
VAL C 246
ALA C 245
 None
 1.14A 4fqsA-3d31C:
undetectable		 4fqsA-3d31C:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 3d31 SULFATE/MOLYBDATE
ABC TRANSPORTER,
PERMEASE PROTEIN
(Methanosarcina
acetivorans) 		5 / 12 ILE C  41
GLY C  47
PHE C  45
VAL C 246
ALA C 245
 None
 1.15A 4fqsB-3d31C:
undetectable		 4fqsB-3d31C:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 3d31 SULFATE/MOLYBDATE
ABC TRANSPORTER,
PERMEASE PROTEIN
(Methanosarcina
acetivorans) 		3 / 3 PRO C 222
MET C 223
TYR C 221
 None
 1.12A 4qa0B-3d31C:
undetectable		 4qa0B-3d31C:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 3d31 SULFATE/MOLYBDATE
ABC TRANSPORTER,
PERMEASE PROTEIN
(Methanosarcina
acetivorans) 		3 / 3 PRO C 222
MET C 223
TYR C 221
 None
 0.92A 4qa2B-3d31C:
undetectable		 4qa2B-3d31C:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 3d31 SULFATE/MOLYBDATE
ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		4 / 5 LEU A 151
VAL A  23
TYR A  28
ARG A  56
 None
 1.05A 4r7iA-3d31A:
undetectable		 4r7iA-3d31A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 3d31 SULFATE/MOLYBDATE
ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		5 / 11 GLN A 134
SER A 156
ASP A 187
THR A 185
GLU A 153
 None
 1.41A 5jh7D-3d31A:
undetectable		 5jh7D-3d31A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3d31 SULFATE/MOLYBDATE
ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		3 / 3 LEU A 120
THR A 162
ASN A 165
 None
 0.71A 6baaE-3d31A:
6.4		 6baaE-3d31A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3d31 SULFATE/MOLYBDATE
ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		3 / 3 LEU A 120
THR A 162
ASN A 165
 None
 0.71A 6baaF-3d31A:
6.4		 6baaF-3d31A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3d31 SULFATE/MOLYBDATE
ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		3 / 3 LEU A 120
THR A 162
ASN A 165
 None
 0.71A 6baaG-3d31A:
6.4		 6baaG-3d31A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3d31 SULFATE/MOLYBDATE
ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		3 / 3 LEU A 120
THR A 162
ASN A 165
 None
 0.71A 6baaH-3d31A:
6.0		 6baaH-3d31A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 3d31 SULFATE/MOLYBDATE
ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		3 / 3 TYR A  81
PRO A 154
LEU A 151
 None
 0.94A 6beoA-3d31A:
undetectable		 6beoA-3d31A:
3.12