SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3d34'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3d34 SPONDIN-2
(Homo
sapiens) 		4 / 6 VAL A 139
GLY A 138
LEU A 158
TYR A 161
 None
 1.04A 1fduD-3d34A:
undetectable		 1fduD-3d34A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDW_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3d34 SPONDIN-2
(Homo
sapiens) 		5 / 10 VAL A 126
LEU A  80
VAL A  64
PHE A 136
GLU A  73
 None
 1.18A 1fdwA-3d34A:
undetectable		 1fdwA-3d34A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA8_0
(GRAMICIDIN A)		 3d34 SPONDIN-2
(Homo
sapiens) 		3 / 4 VAL A 127
TRP A 135
TRP A  43
 None
 1.21A 1gmkA-3d34A:
undetectable
1gmkB-3d34A:
undetectable		 1gmkA-3d34A:
9.30
1gmkB-3d34A:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 3d34 SPONDIN-2
(Homo
sapiens) 		3 / 4 VAL A 127
TRP A 135
TRP A  43
 None
 1.07A 1gmkC-3d34A:
undetectable
1gmkD-3d34A:
undetectable		 1gmkC-3d34A:
9.30
1gmkD-3d34A:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1470_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 3d34 SPONDIN-2
(Homo
sapiens) 		4 / 5 ARG A 128
ALA A  72
ASP A 134
TRP A 135
 None
None
CA  A 228 (-2.3A)
None
 1.36A 2xrzA-3d34A:
undetectable		 2xrzA-3d34A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		 3d34 SPONDIN-2
(Homo
sapiens) 		4 / 8 ASP A 134
PHE A 169
ASP A 162
GLY A 164
 CA  A 228 (-2.3A)
None
CA  A 228 (-2.1A)
CA  A 228 ( 4.4A)
 0.83A 3c0zB-3d34A:
undetectable		 3c0zB-3d34A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		 3d34 SPONDIN-2
(Homo
sapiens) 		3 / 3 MET A  57
VAL A  97
GLU A  83
 None
 0.86A 3c6gA-3d34A:
undetectable		 3c6gA-3d34A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3d34 SPONDIN-2
(Homo
sapiens) 		5 / 12 GLY A  48
LEU A 158
VAL A 213
ILE A  19
LEU A  68
 None
 1.26A 3g9eA-3d34A:
undetectable		 3g9eA-3d34A:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3d34 SPONDIN-2
(Homo
sapiens) 		4 / 6 PHE A  98
ILE A  19
ALA A 112
THR A 110
 None
 1.12A 3mdrA-3d34A:
undetectable		 3mdrA-3d34A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 3d34 SPONDIN-2
(Homo
sapiens) 		4 / 7 PHE A  98
ILE A 129
LEU A 158
THR A 110
 None
 0.97A 3nxuA-3d34A:
undetectable		 3nxuA-3d34A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 3d34 SPONDIN-2
(Homo
sapiens) 		3 / 3 THR A 170
PRO A 133
ASP A 166
 None
 0.81A 5l8dB-3d34A:
undetectable		 5l8dB-3d34A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 3d34 SPONDIN-2
(Homo
sapiens) 		3 / 3 THR A 170
PRO A 133
ASP A 166
 None
 0.81A 5mwuB-3d34A:
undetectable		 5mwuB-3d34A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3d34 SPONDIN-2
(Homo
sapiens) 		4 / 5 GLN A  42
VAL A 103
TRP A  43
THR A  22
 None
 1.28A 6cduA-3d34A:
undetectable
6cduB-3d34A:
undetectable		 6cduA-3d34A:
20.95
6cduB-3d34A:
20.95