SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3d36'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 3d36 SPORULATION KINASE B
SPORULATION KINASE
INHIBITOR SDA
(Geobacillus
stearothermophil
us;
Geobacillus
stearothermophil
us) 		3 / 3 GLU A 249
ILE A 245
ARG C  36
 None
 0.82A 1cd2A-3d36A:
undetectable		 1cd2A-3d36A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 3d36 SPORULATION KINASE B
(Geobacillus
stearothermophil
us) 		4 / 8 ARG A 282
ARG A 311
LEU A 274
GLU A 272
 None
 0.96A 1cmaA-3d36A:
undetectable
1cmaB-3d36A:
undetectable		 1cmaA-3d36A:
18.18
1cmaB-3d36A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 3d36 SPORULATION KINASE B
(Geobacillus
stearothermophil
us) 		4 / 7 SER A 391
GLU A 310
GLU A 269
GLU A 312
 None
 1.09A 1knyA-3d36A:
undetectable
1knyB-3d36A:
undetectable		 1knyA-3d36A:
20.49
1knyB-3d36A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_0
(PROTEIN (METHIONINE
REPRESSOR))		 3d36 SPORULATION KINASE B
(Geobacillus
stearothermophil
us) 		5 / 9 GLU A 279
ARG A 282
ARG A 311
LEU A 274
GLU A 272
 None
 1.41A 1mj2A-3d36A:
undetectable		 1mj2A-3d36A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_0
(PROTEIN (METHIONINE
REPRESSOR))		 3d36 SPORULATION KINASE B
(Geobacillus
stearothermophil
us) 		5 / 9 GLU A 279
ARG A 282
ARG A 311
LEU A 274
GLU A 272
 None
 1.42A 1mj2C-3d36A:
undetectable		 1mj2C-3d36A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 3d36 SPORULATION KINASE B
(Geobacillus
stearothermophil
us) 		5 / 11 GLU A 279
ARG A 282
ARG A 311
LEU A 274
GLU A 272
 None
 1.35A 1mjlA-3d36A:
undetectable
1mjlB-3d36A:
undetectable		 1mjlA-3d36A:
18.61
1mjlB-3d36A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_0
(METHIONINE REPRESSOR)		 3d36 SPORULATION KINASE B
(Geobacillus
stearothermophil
us) 		5 / 9 GLU A 279
ARG A 282
ARG A 311
LEU A 274
GLU A 272
 None
 1.41A 1mjoA-3d36A:
undetectable		 1mjoA-3d36A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_1
(METHIONINE REPRESSOR)		 3d36 SPORULATION KINASE B
(Geobacillus
stearothermophil
us) 		5 / 9 GLU A 279
ARG A 282
ARG A 311
LEU A 274
GLU A 272
 None
 1.43A 1mjoB-3d36A:
undetectable		 1mjoB-3d36A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_0
(METHIONINE REPRESSOR)		 3d36 SPORULATION KINASE B
(Geobacillus
stearothermophil
us) 		5 / 9 GLU A 279
ARG A 282
ARG A 311
LEU A 274
GLU A 272
 None
 1.43A 1mjoC-3d36A:
undetectable		 1mjoC-3d36A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3d36 SPORULATION KINASE B
(Geobacillus
stearothermophil
us) 		4 / 7 TYR A 260
GLY A 381
TYR A 369
ASN A 320
 None
ADP  A 500 (-3.7A)
None
None
 1.01A 2g70A-3d36A:
undetectable		 2g70A-3d36A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3d36 SPORULATION KINASE B
(Geobacillus
stearothermophil
us) 		4 / 7 TYR A 260
GLY A 381
TYR A 369
ASN A 320
 None
ADP  A 500 (-3.7A)
None
None
 1.02A 2g70B-3d36A:
undetectable		 2g70B-3d36A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3d36 SPORULATION KINASE B
(Geobacillus
stearothermophil
us) 		4 / 6 TYR A 260
GLY A 381
TYR A 369
ASN A 320
 None
ADP  A 500 (-3.7A)
None
None
 1.04A 2g72A-3d36A:
undetectable		 2g72A-3d36A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3d36 SPORULATION KINASE B
(Geobacillus
stearothermophil
us) 		4 / 7 TYR A 260
GLY A 381
TYR A 369
ASN A 320
 None
ADP  A 500 (-3.7A)
None
None
 1.08A 2g72B-3d36A:
undetectable		 2g72B-3d36A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 3d36 SPORULATION KINASE B
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A 280
ILE A 410
ILE A 388
LEU A 319
VAL A 337
 None
 1.02A 3fpjB-3d36A:
undetectable		 3fpjB-3d36A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3d36 SPORULATION KINASE B
(Geobacillus
stearothermophil
us) 		4 / 6 MET A 382
VAL A 385
ILE A 398
ILE A 389
 None
 0.90A 3gcsA-3d36A:
undetectable		 3gcsA-3d36A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC2_1
(CYTOCHROME P450 2D6)		 3d36 SPORULATION KINASE B
(Geobacillus
stearothermophil
us) 		5 / 10 THR A 262
THR A 378
LEU A 319
VAL A 321
PHE A 263
 None
ADP  A 500 (-3.7A)
None
None
None
 1.49A 3tbgC-3d36A:
undetectable		 3tbgC-3d36A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD393_1
(TETX2 PROTEIN)		 3d36 SPORULATION KINASE B
(Geobacillus
stearothermophil
us) 		4 / 5 ILE A 398
ILE A 389
TYR A 386
GLU A 390
 None
 1.15A 4a99D-3d36A:
undetectable		 4a99D-3d36A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_2
(ANDROGEN RECEPTOR)		 3d36 SPORULATION KINASE B
(Geobacillus
stearothermophil
us) 		4 / 8 ASN A 320
MET A 357
LEU A 365
ILE A 389
 None
ADP  A 500 (-3.6A)
ADP  A 500 (-4.3A)
None
 1.03A 4ok1A-3d36A:
undetectable		 4ok1A-3d36A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)		 3d36 SPORULATION KINASE B
(Geobacillus
stearothermophil
us) 		4 / 7 ASN A 320
MET A 357
LEU A 365
ILE A 389
 None
ADP  A 500 (-3.6A)
ADP  A 500 (-4.3A)
None
 1.05A 4okwA-3d36A:
undetectable		 4okwA-3d36A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 3d36 SPORULATION KINASE B
(Geobacillus
stearothermophil
us) 		4 / 8 HIS A 213
ASN A 217
GLU A 214
ARG A 252
 None
 1.17A 6b94A-3d36A:
undetectable		 6b94A-3d36A:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_D95A816_0
(GEPHYRIN)		 3d36 SPORULATION KINASE B
SPORULATION KINASE
INHIBITOR SDA
(Geobacillus
stearothermophil
us;
Geobacillus
stearothermophil
us) 		5 / 11 PHE C  25
LEU C  21
LEU C  28
ILE A 245
MET C   1
 None
 1.24A 6fgcA-3d36C:
undetectable		 6fgcA-3d36C:
18.75