SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3d3d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		 3d3d LYSOZYME
(Escherichia
virus
Lambda) 		4 / 8 LEU A  12
LEU A  15
SER A  18
THR A  21
 None
 0.94A 1dvtA-3d3dA:
undetectable
1dvtB-3d3dA:
undetectable		 1dvtA-3d3dA:
19.75
1dvtB-3d3dA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3d3d LYSOZYME
(Escherichia
virus
Lambda) 		5 / 12 ALA A 104
LEU A  12
ALA A  10
LEU A  96
ILE A  99
 None
 1.10A 1g5yB-3d3dA:
undetectable		 1g5yB-3d3dA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3d3d LYSOZYME
(Escherichia
virus
Lambda) 		5 / 9 ASP A  47
VAL A  53
THR A  62
GLN A  68
GLY A  63
 None
 1.41A 4acaB-3d3dA:
undetectable
4acaC-3d3dA:
undetectable		 4acaB-3d3dA:
16.35
4acaC-3d3dA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 3d3d LYSOZYME
(Escherichia
virus
Lambda) 		4 / 6 LEU A  12
LEU A  15
SER A  18
THR A  21
 None
 0.99A 4d7bB-3d3dA:
undetectable		 4d7bB-3d3dA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 3d3d LYSOZYME
(Escherichia
virus
Lambda) 		4 / 6 LEU A  12
LEU A  15
SER A  18
THR A  21
 None
 0.96A 4i89A-3d3dA:
undetectable		 4i89A-3d3dA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 3d3d LYSOZYME
(Escherichia
virus
Lambda) 		3 / 3 ARG A  78
ASP A  75
TRP A  74
 None
 0.98A 4xdqA-3d3dA:
undetectable		 4xdqA-3d3dA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 3d3d LYSOZYME
(Escherichia
virus
Lambda) 		4 / 6 LEU A  12
LEU A  15
SER A  18
THR A  21
 None
 1.00A 5bojA-3d3dA:
undetectable		 5bojA-3d3dA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 3d3d LYSOZYME
(Escherichia
virus
Lambda) 		4 / 7 LEU A  12
LEU A  15
SER A  18
THR A  21
 None
 0.99A 5bojB-3d3dA:
undetectable		 5bojB-3d3dA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 3d3d LYSOZYME
(Escherichia
virus
Lambda) 		4 / 6 LEU A  12
LEU A  15
SER A  18
THR A  21
 None
 1.01A 5l4iA-3d3dA:
undetectable		 5l4iA-3d3dA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 3d3d LYSOZYME
(Escherichia
virus
Lambda) 		4 / 6 LEU A  12
LEU A  15
SER A  18
THR A  21
 None
 0.99A 5l4iB-3d3dA:
undetectable		 5l4iB-3d3dA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3d3d LYSOZYME
(Escherichia
virus
Lambda) 		3 / 3 TYR A  33
ALA A  95
TYR A  67
 None
 0.83A 5uunB-3d3dA:
undetectable		 5uunB-3d3dA:
20.14