SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3d3f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3d3f YVGN PROTEIN
(Bacillus
subtilis) 		4 / 5 THR A 122
THR A  90
THR A  77
HIS A 112
 None
None
None
NDP  A   1 (-4.0A)
 1.10A 1d4fB-3d3fA:
undetectable		 1d4fB-3d3fA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		 3d3f YVGN PROTEIN
(Bacillus
subtilis) 		3 / 3 ASP A 121
TYR A  87
GLU A 127
 None
 0.86A 1vm1A-3d3fA:
undetectable		 1vm1A-3d3fA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3d3f YVGN PROTEIN
(Bacillus
subtilis) 		3 / 3 ASN A 142
TRP A 189
GLN A 144
 NDP  A   1 (-3.3A)
NDP  A   1 (-3.3A)
None
 1.42A 1xoqA-3d3fA:
undetectable		 1xoqA-3d3fA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3d3f YVGN PROTEIN
(Bacillus
subtilis) 		4 / 7 ARG A  71
LEU A 103
GLN A 102
LEU A 106
 None
 1.06A 2eijC-3d3fA:
undetectable
2eijJ-3d3fA:
undetectable		 2eijC-3d3fA:
20.40
2eijJ-3d3fA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3d3f YVGN PROTEIN
(Bacillus
subtilis) 		4 / 7 ARG A  71
LEU A 103
GLN A 102
LEU A 106
 None
 1.05A 2einC-3d3fA:
undetectable
2einJ-3d3fA:
undetectable		 2einC-3d3fA:
20.40
2einJ-3d3fA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3d3f YVGN PROTEIN
(Bacillus
subtilis) 		4 / 6 ARG A  71
LEU A 103
GLN A 102
LEU A 106
 None
 1.01A 2einP-3d3fA:
undetectable
2einW-3d3fA:
undetectable		 2einP-3d3fA:
20.40
2einW-3d3fA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 3d3f YVGN PROTEIN
(Bacillus
subtilis) 		4 / 6 LEU A 198
TRP A 221
MET A 255
LEU A 261
 NDP  A   1 (-4.8A)
None
None
None
 1.32A 2oz7A-3d3fA:
undetectable		 2oz7A-3d3fA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3d3f YVGN PROTEIN
(Bacillus
subtilis) 		4 / 8 ALA A 188
ASP A 222
ILE A 218
THR A 229
 None
 0.79A 2w9sE-3d3fA:
undetectable		 2w9sE-3d3fA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X08_A_ASCA1253_0
(CYTOCHROME C
PEROXIDASE,
MITOCHONDRIAL)		 3d3f YVGN PROTEIN
(Bacillus
subtilis) 		5 / 9 ALA A 260
ASP A 259
ILE A 258
PRO A 168
HIS A 225
 None
 1.27A 2x08A-3d3fA:
0.0		 2x08A-3d3fA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X08_A_ASCA1253_0
(CYTOCHROME C
PEROXIDASE,
MITOCHONDRIAL)		 3d3f YVGN PROTEIN
(Bacillus
subtilis) 		5 / 9 ASP A 259
ILE A 258
PRO A 168
HIS A 225
ARG A 176
 None
 1.03A 2x08A-3d3fA:
0.0		 2x08A-3d3fA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 3d3f YVGN PROTEIN
(Bacillus
subtilis) 		5 / 11 ILE A 135
ALA A 125
ILE A 111
VAL A  80
GLY A 139
 None
 0.86A 3kw4A-3d3fA:
undetectable		 3kw4A-3d3fA:
21.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG8_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3d3f YVGN PROTEIN
(Bacillus
subtilis) 		5 / 12 TYR A  54
TRP A  81
HIS A 112
ASN A 142
SER A 190
 NDP  A   1 (-4.8A)
None
NDP  A   1 (-4.0A)
NDP  A   1 (-3.3A)
NDP  A   1 (-2.7A)
 0.44A 3ug8A-3d3fA:
38.4		 3ug8A-3d3fA:
39.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 3d3f YVGN PROTEIN
(Bacillus
subtilis) 		4 / 8 THR A  50
LEU A 103
LEU A 101
GLY A  61
 None
 0.87A 4c9nA-3d3fA:
undetectable		 4c9nA-3d3fA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3d3f YVGN PROTEIN
(Bacillus
subtilis) 		3 / 3 SER A 213
ASP A   7
ASP A 244
 NDP  A   1 ( 4.9A)
None
None
 0.78A 4uckA-3d3fA:
undetectable		 4uckA-3d3fA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 3d3f YVGN PROTEIN
(Bacillus
subtilis) 		5 / 12 THR A  50
ALA A  51
ILE A 230
GLY A  23
LEU A 110
 None
None
NDP  A   1 (-4.6A)
NDP  A   1 (-2.9A)
None
 0.84A 5nfjA-3d3fA:
undetectable		 5nfjA-3d3fA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 3d3f YVGN PROTEIN
(Bacillus
subtilis) 		4 / 7 GLN A  85
GLY A 115
GLN A 172
TRP A 113
 None
None
None
NDP  A   1 ( 4.2A)
 1.06A 5vlmC-3d3fA:
undetectable		 5vlmC-3d3fA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB503_0
(AMINE OXIDASE LKCE)		 3d3f YVGN PROTEIN
(Bacillus
subtilis) 		3 / 3 VAL A  27
GLU A  28
ILE A 234
 None
None
NDP  A   1 (-4.1A)
 0.40A 6f7lB-3d3fA:
undetectable		 6f7lB-3d3fA:
21.10