SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3d3l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE
(Homo
sapiens) 		4 / 6 LEU A 241
ASP A 351
MET A 302
LEU A 273
 None
 1.20A 1errB-3d3lA:
undetectable		 1errB-3d3lA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE
(Homo
sapiens) 		4 / 8 TYR A 483
PHE A 482
ILE A 478
LEU A 529
 None
 0.84A 1eupA-3d3lA:
undetectable		 1eupA-3d3lA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE
(Homo
sapiens) 		5 / 9 ALA A 510
PHE A 515
GLY A 506
LEU A 362
LEU A 436
 None
 1.11A 1nr6A-3d3lA:
undetectable		 1nr6A-3d3lA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RKY_A_CUA801_0
(LYSYL OXIDASE)		 3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE
(Homo
sapiens) 		3 / 3 HIS A 365
HIS A 360
HIS A 540
 FE  A 801 (-3.0A)
FE  A 801 (-3.1A)
FE  A 801 (-3.1A)
 0.69A 1rkyA-3d3lA:
undetectable		 1rkyA-3d3lA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_B_EDTB1511_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE
(Homo
sapiens) 		4 / 8 TYR A 651
TRP A 550
TRP A 647
TYR A 230
 None
 1.48A 1zlqB-3d3lA:
0.0		 1zlqB-3d3lA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE
(Homo
sapiens) 		5 / 11 VAL A 315
GLU A 275
ALA A 276
PRO A 248
PHE A 232
 None
 1.28A 2admB-3d3lA:
undetectable		 2admB-3d3lA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE
(Homo
sapiens) 		4 / 5 LEU A 241
ASP A 351
MET A 302
LEU A 273
 None
 1.24A 2jfaA-3d3lA:
undetectable		 2jfaA-3d3lA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE
(Homo
sapiens) 		3 / 3 PRO A 648
ASN A 642
ARG A 641
 None
 1.05A 2qeuB-3d3lA:
undetectable		 2qeuB-3d3lA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE
(Homo
sapiens) 		4 / 8 ILE A 471
PHE A 388
GLY A 608
ILE A 657
 None
 0.92A 2qwxA-3d3lA:
undetectable
2qwxB-3d3lA:
undetectable		 2qwxA-3d3lA:
18.68
2qwxB-3d3lA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE
(Homo
sapiens) 		4 / 5 LEU A 241
ASP A 351
MET A 302
LEU A 273
 None
 1.19A 2qxsA-3d3lA:
undetectable		 2qxsA-3d3lA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE
(Homo
sapiens) 		4 / 5 LEU A 241
ASP A 351
MET A 302
LEU A 273
 None
 1.19A 2qxsB-3d3lA:
undetectable		 2qxsB-3d3lA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE
(Homo
sapiens) 		5 / 11 ILE A 470
ALA A 472
PHE A 627
THR A 537
PRO A 391
 None
 1.23A 2w3aA-3d3lA:
undetectable		 2w3aA-3d3lA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE
(Homo
sapiens) 		4 / 5 ILE A 502
TYR A 438
MET A 531
THR A 530
 None
 1.21A 3abkN-3d3lA:
undetectable
3abkW-3d3lA:
undetectable		 3abkN-3d3lA:
22.99
3abkW-3d3lA:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_A_SAMA206_0
(UPF0217 PROTEIN
MJ1640)		 3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE
(Homo
sapiens) 		4 / 6 GLY A 477
LEU A 525
SER A 521
CYH A 526
 None
 0.75A 3aiaA-3d3lA:
undetectable		 3aiaA-3d3lA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE
(Homo
sapiens) 		3 / 3 SER A 350
GLN A 353
PHE A 352
 None
 0.83A 3g4lC-3d3lA:
undetectable		 3g4lC-3d3lA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_CUB801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE
(Homo
sapiens) 		3 / 3 HIS A 365
HIS A 360
HIS A 540
 FE  A 801 (-3.0A)
FE  A 801 (-3.1A)
FE  A 801 (-3.1A)
 0.73A 3hiiB-3d3lA:
undetectable		 3hiiB-3d3lA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE
(Homo
sapiens) 		4 / 7 HIS A 462
GLU A 643
ARG A 641
GLU A 637
 None
 1.28A 3ql6A-3d3lA:
1.1		 3ql6A-3d3lA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R4X_A_PZAA598_0
(LACTOPEROXIDASE)		 3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE
(Homo
sapiens) 		4 / 5 PHE A 627
ARG A 628
GLU A 632
PRO A 654
 None
 0.97A 3r4xA-3d3lA:
0.0		 3r4xA-3d3lA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE
(Homo
sapiens) 		4 / 6 TYR A 474
VAL A 533
HIS A 392
THR A 530
 None
 0.98A 3tj7A-3d3lA:
undetectable
3tj7B-3d3lA:
undetectable		 3tj7A-3d3lA:
18.88
3tj7B-3d3lA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE
(Homo
sapiens) 		4 / 6 TYR A 474
VAL A 533
HIS A 392
THR A 530
 None
 0.98A 3tj7C-3d3lA:
undetectable
3tj7D-3d3lA:
undetectable		 3tj7C-3d3lA:
18.88
3tj7D-3d3lA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE
(Homo
sapiens) 		4 / 7 TYR A 614
ILE A 390
PHE A 386
MET A 376
 None
 0.95A 3tvxB-3d3lA:
undetectable		 3tvxB-3d3lA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)		 3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE
(Homo
sapiens) 		5 / 12 LEU A 389
THR A 503
ILE A 502
PHE A 519
LEU A 525
 None
 1.09A 3vw1B-3d3lA:
undetectable		 3vw1B-3d3lA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE
(Homo
sapiens) 		4 / 5 LEU A 631
HIS A 609
HIS A 392
HIS A 610
 None
 1.27A 4a7bB-3d3lA:
undetectable		 4a7bB-3d3lA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE
(Homo
sapiens) 		3 / 3 LYS A 653
PRO A 654
SER A 655
 None
 0.41A 4k50I-3d3lA:
undetectable		 4k50I-3d3lA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OES_A_EDTA601_0
(NIKA PROTEIN)		 3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE
(Homo
sapiens) 		4 / 6 TYR A 651
TRP A 550
TRP A 647
TYR A 230
 None
 1.40A 4oesA-3d3lA:
0.0		 4oesA-3d3lA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA603_1
(SERUM ALBUMIN)		 3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE
(Homo
sapiens) 		5 / 11 LEU A 241
ARG A 242
LEU A 273
LEU A 452
LEU A 303
 None
 1.30A 4or0A-3d3lA:
1.8		 4or0A-3d3lA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)		 3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE
(Homo
sapiens) 		5 / 11 LEU A 241
ARG A 242
LEU A 273
LEU A 452
LEU A 303
 None
 1.32A 4or0B-3d3lA:
2.1		 4or0B-3d3lA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE
(Homo
sapiens) 		5 / 12 GLU A 504
VAL A 505
ARG A 500
HIS A 383
PHE A 519
 None
 1.36A 4q15A-3d3lA:
undetectable		 4q15A-3d3lA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE
(Homo
sapiens) 		4 / 8 ILE A 471
PHE A 388
GLY A 608
ILE A 657
 None
 0.92A 4qogA-3d3lA:
undetectable
4qogB-3d3lA:
undetectable		 4qogA-3d3lA:
18.68
4qogB-3d3lA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE
(Homo
sapiens) 		3 / 3 ARG A 450
ASP A 446
TYR A 460
 None
 0.90A 4yo9B-3d3lA:
undetectable		 4yo9B-3d3lA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE
(Homo
sapiens) 		3 / 3 PRO A 558
LEU A 296
SER A 345
 None
 0.60A 5fsaB-3d3lA:
1.9		 5fsaB-3d3lA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE
(Homo
sapiens) 		5 / 12 PHE A 534
GLY A 608
ARG A 628
LEU A 652
ALA A 538
 None
 1.04A 5h5fA-3d3lA:
undetectable		 5h5fA-3d3lA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_B_RBFB201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE
(Homo
sapiens) 		5 / 12 GLY A 235
ASN A 237
ALA A 557
ASN A 556
TYR A 230
 None
 1.40A 5kbwB-3d3lA:
1.4		 5kbwB-3d3lA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE
(Homo
sapiens) 		3 / 3 LEU A 338
LEU A 342
TRP A 346
 None
 0.94A 5nwuA-3d3lA:
undetectable		 5nwuA-3d3lA:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_C_9UQC202_0
(CEREBLON ISOFORM 4)		 3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE
(Homo
sapiens) 		4 / 8 GLU A 650
TRP A 550
TRP A 647
TYR A 230
 None
 1.37A 5oh1C-3d3lA:
undetectable		 5oh1C-3d3lA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA810_1
(CATALASE-PEROXIDASE)		 3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE
(Homo
sapiens) 		4 / 6 ARG A 641
HIS A 462
LEU A 467
PRO A 654
 None
 1.46A 5syjA-3d3lA:
undetectable		 5syjA-3d3lA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)		 3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE
(Homo
sapiens) 		5 / 12 LEU A 183
SER A 440
ARG A 430
GLN A 427
LEU A 280
 None
 1.23A 6ew0F-3d3lA:
undetectable		 6ew0F-3d3lA:
8.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_A_H98A501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE
(Homo
sapiens) 		5 / 12 VAL A 367
ASP A 512
PHE A 515
PHE A 528
VAL A 517
 None
 1.28A 6iblA-3d3lA:
undetectable		 6iblA-3d3lA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_B_H98B501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE
(Homo
sapiens) 		5 / 12 VAL A 367
ASP A 512
PHE A 515
PHE A 528
VAL A 517
 None
 1.25A 6iblB-3d3lA:
undetectable		 6iblB-3d3lA:
22.34