SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3d3m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 3d3m EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		5 / 11 VAL A 887
LEU A 848
LEU A 777
HIS A 854
GLU A 805
 None
 1.34A 1mmtA-3d3mA:
undetectable		 1mmtA-3d3mA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3d3m EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		4 / 7 ILE A 861
MET A 773
THR A 774
LEU A 777
 None
 0.84A 1v55A-3d3mA:
undetectable
1v55J-3d3mA:
undetectable		 1v55A-3d3mA:
15.54
1v55J-3d3mA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3d3m EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		4 / 8 ILE A 861
MET A 773
THR A 774
LEU A 777
 None
 0.78A 2einA-3d3mA:
undetectable
2einJ-3d3mA:
undetectable		 2einA-3d3mA:
15.54
2einJ-3d3mA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3d3m EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		4 / 6 ILE A 861
MET A 773
THR A 774
LEU A 777
 None
 0.85A 2einN-3d3mA:
undetectable
2einW-3d3mA:
undetectable		 2einN-3d3mA:
15.54
2einW-3d3mA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 3d3m EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		4 / 7 VAL A 828
TYR A 832
ASN A 770
GLY A 767
 None
 0.89A 2y05A-3d3mA:
undetectable
2y05B-3d3mA:
undetectable		 2y05A-3d3mA:
18.01
2y05B-3d3mA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3d3m EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		4 / 6 ILE A 861
MET A 773
THR A 774
LEU A 777
 None
 0.84A 3ag1N-3d3mA:
undetectable
3ag1W-3d3mA:
undetectable		 3ag1N-3d3mA:
15.54
3ag1W-3d3mA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3d3m EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		4 / 6 GLU A 864
PHE A 866
HIS A 821
VAL A 769
 None
 1.08A 4a97E-3d3mA:
2.0		 4a97E-3d3mA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3d3m EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		4 / 4 ASN A 770
SER A 759
LEU A 762
THR A 774
 None
 1.14A 4an2A-3d3mA:
undetectable		 4an2A-3d3mA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3d3m EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		4 / 6 GLN A 817
PHE A 776
LEU A 772
PHE A 768
 None
 1.10A 5b1bC-3d3mA:
undetectable
5b1bJ-3d3mA:
undetectable		 5b1bC-3d3mA:
21.29
5b1bJ-3d3mA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 3d3m EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		4 / 7 ILE A 750
ILE A 758
SER A 775
PHE A 776
 None
 0.75A 5fukA-3d3mA:
undetectable
5fukB-3d3mA:
undetectable		 5fukA-3d3mA:
20.68
5fukB-3d3mA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 3d3m EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		4 / 7 ILE A 758
ILE A 771
SER A 775
PHE A 776
 None
 0.62A 5fukA-3d3mA:
undetectable
5fukB-3d3mA:
undetectable		 5fukA-3d3mA:
20.68
5fukB-3d3mA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3d3m EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		4 / 6 GLN A 817
PHE A 776
LEU A 772
PHE A 768
 None
 1.06A 5z86C-3d3mA:
undetectable
5z86J-3d3mA:
undetectable		 5z86C-3d3mA:
21.29
5z86J-3d3mA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3d3m EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		4 / 6 GLN A 817
PHE A 776
LEU A 772
PHE A 768
 None
 1.11A 5z86P-3d3mA:
undetectable
5z86W-3d3mA:
undetectable		 5z86P-3d3mA:
21.29
5z86W-3d3mA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3d3m EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		4 / 6 GLN A 817
PHE A 776
LEU A 772
PHE A 768
 None
 1.13A 5zcoP-3d3mA:
undetectable
5zcoW-3d3mA:
undetectable		 5zcoP-3d3mA:
21.29
5zcoW-3d3mA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3d3m EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens) 		4 / 6 GLN A 817
PHE A 776
LEU A 772
PHE A 768
 None
 1.06A 5zcpC-3d3mA:
undetectable
5zcpJ-3d3mA:
undetectable		 5zcpC-3d3mA:
21.29
5zcpJ-3d3mA:
17.20