SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3d3o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		 3d3o PUTATIVE
TRANSCRIPTIONAL
REGULATOR, ICIR
FAMILY
(Acinetobacter
sp.
ADP1) 		5 / 12 LEU A 159
GLY A 161
MET A 138
MET A  64
LEU A 126
 None
 1.41A 1nhzA-3d3oA:
undetectable		 1nhzA-3d3oA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		 3d3o PUTATIVE
TRANSCRIPTIONAL
REGULATOR, ICIR
FAMILY
(Acinetobacter
sp.
ADP1) 		5 / 12 LEU A 159
GLY A 161
VAL A  10
MET A 138
LEU A 126
 None
 1.35A 1nhzA-3d3oA:
undetectable		 1nhzA-3d3oA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3d3o PUTATIVE
TRANSCRIPTIONAL
REGULATOR, ICIR
FAMILY
(Acinetobacter
sp.
ADP1) 		3 / 3 ASN A  61
ILE A 101
MET A  69
 SO4  A 176 ( 4.9A)
None
None
 0.61A 2h42C-3d3oA:
undetectable		 2h42C-3d3oA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD302_0
(GLUTATHIONE
TRANSFERASE GTE1)		 3d3o PUTATIVE
TRANSCRIPTIONAL
REGULATOR, ICIR
FAMILY
(Acinetobacter
sp.
ADP1) 		3 / 3 TYR A  34
PHE A 117
ARG A  54
 SO4  A 177 ( 4.5A)
SO4  A 177 (-4.6A)
SO4  A 177 (-3.7A)
 1.16A 4g19D-3d3oA:
undetectable		 4g19D-3d3oA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 3d3o PUTATIVE
TRANSCRIPTIONAL
REGULATOR, ICIR
FAMILY
(Acinetobacter
sp.
ADP1) 		3 / 3 MET A  66
GLN A 107
TYR A 109
 None
 1.04A 4udcA-3d3oA:
undetectable		 4udcA-3d3oA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 3d3o PUTATIVE
TRANSCRIPTIONAL
REGULATOR, ICIR
FAMILY
(Acinetobacter
sp.
ADP1) 		5 / 12 LEU A 159
GLY A 161
VAL A  10
MET A  64
LEU A 126
 None
 1.40A 5uc3B-3d3oA:
undetectable		 5uc3B-3d3oA:
18.39