SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3d3u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 3d3u 4-HYDROXYBUTYRATE
COA-TRANSFERASE
(Porphyromonas
gingivalis) 		4 / 7 ILE A 217
LEU A 277
GLY A 273
PHE A 272
 None
 0.89A 1rtsB-3d3uA:
undetectable		 1rtsB-3d3uA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2001_1
(SERUM ALBUMIN)		 3d3u 4-HYDROXYBUTYRATE
COA-TRANSFERASE
(Porphyromonas
gingivalis) 		5 / 12 LEU A 213
ILE A 310
CYH A 203
GLY A 200
LEU A 225
 None
 1.26A 2bxeB-3d3uA:
undetectable		 2bxeB-3d3uA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 3d3u 4-HYDROXYBUTYRATE
COA-TRANSFERASE
(Porphyromonas
gingivalis) 		5 / 10 ILE A 178
ALA A  17
VAL A 119
VAL A 121
VAL A 151
 None
 1.01A 2nnjA-3d3uA:
undetectable		 2nnjA-3d3uA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 3d3u 4-HYDROXYBUTYRATE
COA-TRANSFERASE
(Porphyromonas
gingivalis) 		4 / 8 ASP A  64
SER A  41
HIS A  67
GLU A 155
 None
 1.14A 3sg9B-3d3uA:
undetectable		 3sg9B-3d3uA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3d3u 4-HYDROXYBUTYRATE
COA-TRANSFERASE
(Porphyromonas
gingivalis) 		3 / 3 TYR A 393
HIS A 415
ARG A 419
 None
 1.08A 4e7bC-3d3uA:
undetectable		 4e7bC-3d3uA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3d3u 4-HYDROXYBUTYRATE
COA-TRANSFERASE
(Porphyromonas
gingivalis) 		4 / 6 PHE A  62
VAL A 187
MET A 240
ILE A 217
 None
 0.97A 5iwuA-3d3uA:
undetectable		 5iwuA-3d3uA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 3d3u 4-HYDROXYBUTYRATE
COA-TRANSFERASE
(Porphyromonas
gingivalis) 		4 / 6 SER A 125
GLY A 131
ASN A 128
ILE A 169
 None
 1.12A 5j4nA-3d3uA:
undetectable		 5j4nA-3d3uA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3d3u 4-HYDROXYBUTYRATE
COA-TRANSFERASE
(Porphyromonas
gingivalis) 		3 / 3 ASP A 140
ASN A 167
PHE A  30
 None
 0.87A 5jglB-3d3uA:
2.2		 5jglB-3d3uA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 3d3u 4-HYDROXYBUTYRATE
COA-TRANSFERASE
(Porphyromonas
gingivalis) 		5 / 12 ILE A 253
GLY A 252
LEU A 213
LEU A 215
LEU A 225
 None
 1.00A 5nfjA-3d3uA:
undetectable		 5nfjA-3d3uA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 3d3u 4-HYDROXYBUTYRATE
COA-TRANSFERASE
(Porphyromonas
gingivalis) 		5 / 12 ALA A  17
LEU A  51
ILE A  54
VAL A 121
PHE A  30
 None
 1.39A 5vlmE-3d3uA:
undetectable		 5vlmE-3d3uA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 3d3u 4-HYDROXYBUTYRATE
COA-TRANSFERASE
(Porphyromonas
gingivalis) 		4 / 5 PRO A  24
GLY A  25
THR A  26
ASN A  53
 None
 1.08A 5x23A-3d3uA:
undetectable		 5x23A-3d3uA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 3d3u 4-HYDROXYBUTYRATE
COA-TRANSFERASE
(Porphyromonas
gingivalis) 		4 / 6 PRO A  24
GLY A  25
THR A  26
ASN A  53
 None
 0.98A 5x24A-3d3uA:
undetectable		 5x24A-3d3uA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA502_1
(CYTOCHROME P450 2C9)		 3d3u 4-HYDROXYBUTYRATE
COA-TRANSFERASE
(Porphyromonas
gingivalis) 		4 / 6 PRO A  24
GLY A  25
THR A  26
ASN A  53
 None
 0.94A 5xxiA-3d3uA:
undetectable		 5xxiA-3d3uA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 3d3u 4-HYDROXYBUTYRATE
COA-TRANSFERASE
(Porphyromonas
gingivalis) 		5 / 12 GLY A 337
LYS A 101
SER A 138
ALA A 144
PHE A 110
 None
 1.27A 5zvgB-3d3uA:
2.7		 5zvgB-3d3uA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_1
(NS3 PROTEASE)		 3d3u 4-HYDROXYBUTYRATE
COA-TRANSFERASE
(Porphyromonas
gingivalis) 		5 / 9 VAL A 180
ALA A  17
VAL A  19
SER A  21
ASP A  15
 None
 1.43A 6c2mA-3d3uA:
undetectable		 6c2mA-3d3uA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBF_A_ACTA507_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 3d3u 4-HYDROXYBUTYRATE
COA-TRANSFERASE
(Porphyromonas
gingivalis) 		3 / 3 LYS A 346
SER A 309
SER A 353
 None
 1.14A 6gbfA-3d3uA:
undetectable		 6gbfA-3d3uA:
23.09