SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3d3w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 3d3w L-XYLULOSE REDUCTASE
(Homo
sapiens) 		4 / 8 LEU B  79
ALA B 119
LEU B 122
ILE B 219
 None
 0.92A 3cldB-3d3wB:
undetectable		 3cldB-3d3wB:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 3d3w L-XYLULOSE REDUCTASE
(Homo
sapiens) 		5 / 9 ALA B  36
ILE B 219
VAL B 216
GLY B  20
ILE B  54
 None
 0.97A 4r21B-3d3wB:
undetectable		 4r21B-3d3wB:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 3d3w L-XYLULOSE REDUCTASE
(Homo
sapiens) 		5 / 12 GLN B  25
ALA B  26
LEU B  47
ILE B  54
VAL B  10
 None
 1.32A 5vlmG-3d3wB:
undetectable		 5vlmG-3d3wB:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WQP_A_NCAA302_0
(PROBABLE
DEHYDROGENASE)		 3d3w L-XYLULOSE REDUCTASE
(Homo
sapiens) 		5 / 8 SER B 136
GLN B 137
TYR B 149
TRP B 191
MET B 186
 NAP  B1245 ( 3.0A)
PO4  B 245 (-4.0A)
NAP  B1245 (-4.5A)
PO4  B 245 ( 4.3A)
NAP  B1245 ( 3.8A)
 1.29A 5wqpA-3d3wB:
22.5		 5wqpA-3d3wB:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3d3w L-XYLULOSE REDUCTASE
(Homo
sapiens) 		4 / 6 LEU B  11
VAL B  37
LEU B  61
VAL B  57
 None
None
NAP  B1245 (-3.8A)
None
 0.94A 5x7zA-3d3wB:
undetectable		 5x7zA-3d3wB:
24.08