SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3d43'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		5 / 12 ALA A 167
ALA A 166
VAL A 234
ILE A 246
HIS A  74
 None
 1.03A 1fm6U-3d43A:
undetectable		 1fm6U-3d43A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		5 / 12 SER A 137
GLY A 258
GLY A   9
ALA A 252
VAL A 189
 None
 1.05A 1jg4A-3d43A:
undetectable		 1jg4A-3d43A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		4 / 8 ASN A  47
GLY A  77
THR A 237
GLY A  89
 None
 0.69A 1jr1B-3d43A:
undetectable		 1jr1B-3d43A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		5 / 10 GLY A  72
VAL A  37
LEU A  44
LEU A  80
ALA A 101
 None
 0.93A 1pbcA-3d43A:
2.1		 1pbcA-3d43A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_C_SAMC303_0
(HEMK PROTEIN)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		5 / 12 ILE A  10
VAL A 234
SER A 232
PRO A 254
ALA A 252
 None
 1.11A 1sg9C-3d43A:
undetectable		 1sg9C-3d43A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_2
(POL POLYPROTEIN)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		5 / 12 ALA A  97
ASP A  96
GLY A  92
PRO A 254
ILE A  30
 None
 0.95A 2f80B-3d43A:
undetectable		 2f80B-3d43A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_1
(POL POLYPROTEIN)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		5 / 12 ALA A  97
ASP A  96
GLY A  92
PRO A 254
ILE A  30
 None
 0.96A 2f81A-3d43A:
undetectable		 2f81A-3d43A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_2
(POL POLYPROTEIN)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		5 / 12 ALA A  97
ASP A  96
GLY A  92
PRO A 254
ILE A  30
 None
 0.93A 2f81B-3d43A:
undetectable		 2f81B-3d43A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_1
(PROTEASE)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		5 / 12 ALA A  97
ASP A  96
GLY A  92
PRO A 254
ILE A  30
 None
 1.11A 2o4lA-3d43A:
undetectable		 2o4lA-3d43A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_3
(PROTEASE RETROPEPSIN)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		6 / 12 LEU A 162
ASN A 154
VAL A 153
ILE A 220
VAL A 164
ILE A 163
 None
 1.36A 2q64B-3d43A:
undetectable		 2q64B-3d43A:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_2
(PROTEASE RETROPEPSIN)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		5 / 12 ALA A  97
ASP A  96
GLY A  92
PRO A 254
ILE A  30
 None
 1.06A 2qhcB-3d43A:
undetectable		 2qhcB-3d43A:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_1
(HIV-1 PROTEASE)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		5 / 12 ALA A  97
ASP A  96
GLY A  92
PRO A 254
ILE A  30
 None
 1.05A 3cyxA-3d43A:
undetectable		 3cyxA-3d43A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_2
(HIV-1 PROTEASE)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		5 / 12 ALA A  97
ASP A  96
GLY A  92
PRO A 254
ILE A  30
 None
 0.94A 3d1zB-3d43A:
undetectable		 3d1zB-3d43A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_2
(HIV-1 PROTEASE)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		5 / 12 ALA A  97
ASP A  96
GLY A  92
PRO A 254
ILE A  30
 None
 0.91A 3d20B-3d43A:
undetectable		 3d20B-3d43A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		4 / 8 GLY A 231
GLY A   9
ILE A  10
THR A  78
 None
 0.68A 3d41A-3d43A:
2.7		 3d41A-3d43A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_2
(PROTEASE)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		5 / 11 ALA A  97
ASP A  96
GLY A  92
PRO A 254
ILE A  30
 None
 0.94A 3ektD-3d43A:
undetectable		 3ektD-3d43A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_2
(PROTEASE)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		5 / 9 ALA A  97
ASP A  96
GLY A  92
PRO A 254
ILE A  30
 None
 1.08A 3em4B-3d43A:
undetectable		 3em4B-3d43A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		5 / 12 GLY A  77
SER A 236
THR A 237
ILE A  30
ASP A  43
 None
 1.29A 3iv6B-3d43A:
2.6		 3iv6B-3d43A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		6 / 12 GLY A 303
ALA A 190
ASP A 299
ALA A 294
ILE A 227
ALA A 283
 None
None
CA  A 312 (-3.3A)
None
None
None
 1.33A 3jb1A-3d43A:
undetectable		 3jb1A-3d43A:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		5 / 12 ALA A 166
VAL A  75
GLY A  77
ALA A  76
LEU A  99
 None
 1.04A 3ln1A-3d43A:
undetectable		 3ln1A-3d43A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		5 / 12 ALA A 166
VAL A  75
GLY A  77
ALA A  76
LEU A  99
 None
 1.03A 3ln1B-3d43A:
undetectable		 3ln1B-3d43A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		5 / 12 ALA A 166
VAL A  75
GLY A  77
ALA A  76
LEU A  99
 None
 1.04A 3ln1C-3d43A:
undetectable		 3ln1C-3d43A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		5 / 12 ALA A 166
VAL A  75
GLY A  77
ALA A  76
LEU A  99
 None
 1.03A 3ln1D-3d43A:
undetectable		 3ln1D-3d43A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_2
(HIV-1 PROTEASE)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		5 / 12 ALA A  97
ASP A  96
GLY A  92
PRO A 254
ILE A  30
 None
 0.94A 3lzsB-3d43A:
undetectable		 3lzsB-3d43A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_1
(HIV-1 PROTEASE)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		5 / 12 ALA A  97
ASP A  96
GLY A  92
PRO A 254
ILE A  30
 None
 0.95A 3lzuA-3d43A:
undetectable		 3lzuA-3d43A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		3 / 3 ASP A 125
ARG A 121
ALA A 124
 None
 0.80A 3mbgC-3d43A:
undetectable		 3mbgC-3d43A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		3 / 3 LYS A 159
ARG A 121
LYS A  52
 None
 1.35A 3okxA-3d43A:
undetectable		 3okxA-3d43A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_1
(HIV-1 PROTEASE)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		5 / 12 ALA A  97
ASP A  96
GLY A  92
PRO A 254
ILE A  30
 None
 0.99A 3oxxA-3d43A:
undetectable		 3oxxA-3d43A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_2
(HIV-1 PROTEASE)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		5 / 11 ALA A  97
ASP A  96
GLY A  92
PRO A 254
ILE A  30
 None
 1.00A 3oxxD-3d43A:
undetectable		 3oxxD-3d43A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_1
(HIV-1 PROTEASE)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		5 / 10 ALA A  97
ASP A  96
GLY A  92
PRO A 254
ILE A  30
 None
 0.98A 3ttpA-3d43A:
undetectable		 3ttpA-3d43A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_2
(HIV-1 PROTEASE)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		5 / 10 ALA A  97
ASP A  96
GLY A  92
PRO A 254
ILE A  30
 None
 0.96A 3ttpB-3d43A:
undetectable		 3ttpB-3d43A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1001_1
(HEMOLYTIC LECTIN
CEL-III)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		4 / 5 ASP A 205
VAL A 203
GLY A 291
TYR A 172
 None
 1.49A 3w9tA-3d43A:
undetectable		 3w9tA-3d43A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB503_1
(HEMOLYTIC LECTIN
CEL-III)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		4 / 5 ASP A 205
VAL A 203
GLY A 291
TYR A 172
 None
 1.48A 3w9tB-3d43A:
undetectable		 3w9tB-3d43A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1001_1
(HEMOLYTIC LECTIN
CEL-III)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		4 / 5 ASP A 205
VAL A 203
GLY A 291
TYR A 172
 None
 1.49A 3w9tC-3d43A:
undetectable		 3w9tC-3d43A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD502_1
(HEMOLYTIC LECTIN
CEL-III)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		4 / 5 ASP A 205
VAL A 203
GLY A 291
TYR A 172
 None
 1.47A 3w9tD-3d43A:
undetectable		 3w9tD-3d43A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE504_1
(HEMOLYTIC LECTIN
CEL-III)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		4 / 5 ASP A 205
VAL A 203
GLY A 291
TYR A 172
 None
 1.48A 3w9tE-3d43A:
undetectable		 3w9tE-3d43A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF504_1
(HEMOLYTIC LECTIN
CEL-III)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		4 / 5 ASP A 205
VAL A 203
GLY A 291
TYR A 172
 None
 1.48A 3w9tF-3d43A:
undetectable		 3w9tF-3d43A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG504_1
(HEMOLYTIC LECTIN
CEL-III)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		4 / 5 ASP A 205
VAL A 203
GLY A 291
TYR A 172
 None
 1.48A 3w9tG-3d43A:
undetectable		 3w9tG-3d43A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		4 / 8 LEU A 140
SER A 250
THR A  73
ASP A  67
 None
 1.07A 4drjB-3d43A:
undetectable		 4drjB-3d43A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		4 / 8 ASN A  47
GLY A  77
THR A 237
GLY A  89
 None
 0.69A 4fo4B-3d43A:
undetectable		 4fo4B-3d43A:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		4 / 8 ASN A  38
LEU A  99
LEU A  44
TRP A 238
 None
 0.90A 4jjkA-3d43A:
1.9		 4jjkA-3d43A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_1
(PROTEASE)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		5 / 12 ALA A  97
ASP A  96
GLY A  92
PRO A 254
ILE A  30
 None
 1.07A 4njvA-3d43A:
undetectable		 4njvA-3d43A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		3 / 3 ASP A  67
ASN A 240
SER A 108
 None
 0.55A 4obwA-3d43A:
undetectable		 4obwA-3d43A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		5 / 12 ALA A 186
ALA A 117
ILE A 120
LEU A 140
MET A 138
 CA  A 316 (-4.2A)
None
None
None
None
 0.99A 4r38A-3d43A:
undetectable		 4r38A-3d43A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		5 / 12 ALA A 186
ALA A 117
ILE A 120
LEU A 140
MET A 138
 CA  A 316 (-4.2A)
None
None
None
None
 0.98A 4r38C-3d43A:
undetectable		 4r38C-3d43A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		5 / 12 ALA A 186
ALA A 117
ILE A 120
LEU A 140
MET A 138
 CA  A 316 (-4.2A)
None
None
None
None
 0.98A 4r38D-3d43A:
undetectable		 4r38D-3d43A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		5 / 12 ALA A 186
ALA A 117
ILE A 120
LEU A 140
MET A 138
 CA  A 316 (-4.2A)
None
None
None
None
 1.04A 4r3aA-3d43A:
undetectable		 4r3aA-3d43A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		4 / 6 LEU A 105
ASP A  53
ILE A 149
PRO A  60
 None
 1.10A 4xi3C-3d43A:
undetectable		 4xi3C-3d43A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		4 / 5 LEU A 275
ALA A 261
LEU A 162
VAL A  93
 None
 1.20A 5cr1A-3d43A:
undetectable		 5cr1A-3d43A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		3 / 3 GLY A  24
ASP A  96
ASN A  46
 None
 0.60A 5jglA-3d43A:
2.1		 5jglA-3d43A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		5 / 12 ALA A 166
VAL A  75
GLY A  77
ALA A  76
LEU A  99
 None
 1.05A 5jw1A-3d43A:
undetectable		 5jw1A-3d43A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		3 / 3 GLN A 221
THR A 214
ASP A 224
 CA  A 313 (-2.9A)
CA  A 313 (-4.9A)
CA  A 313 (-2.9A)
 0.77A 5k9dA-3d43A:
undetectable		 5k9dA-3d43A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		5 / 12 ALA A 166
VAL A  75
GLY A  77
ALA A  76
LEU A  99
 None
 1.00A 5kirA-3d43A:
undetectable		 5kirA-3d43A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		5 / 12 ASP A 205
ALA A 191
SER A 232
ARG A 202
GLY A 290
 None
 1.15A 5m54E-3d43A:
2.8		 5m54E-3d43A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		5 / 12 VAL A 189
GLU A 226
LEU A 140
ALA A 165
GLY A 223
 None
 1.17A 5m5cB-3d43A:
undetectable		 5m5cB-3d43A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		5 / 10 VAL A 189
GLU A 226
LEU A 140
ALA A 165
GLY A 223
 None
 1.17A 5m5cE-3d43A:
2.1		 5m5cE-3d43A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_1
(PROTEASE)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		5 / 12 ALA A  97
ASP A  96
GLY A  92
PRO A 254
ILE A  30
 None
 1.03A 5t2zA-3d43A:
undetectable		 5t2zA-3d43A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_0
(HIV-1 PROTEASE)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		5 / 12 ALA A  97
ASP A  96
GLY A  92
PRO A 254
ILE A  30
 None
 1.05A 6difA-3d43A:
undetectable		 6difA-3d43A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_B_GM4B301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3d43 SPHERICASE
(Lysinibacillus
sphaericus) 		5 / 11 VAL A 189
ALA A 252
LEU A 279
ALA A 229
LEU A 192
 None
 1.26A 6dk1B-3d43A:
undetectable		 6dk1B-3d43A:
21.28