SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3d4e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3d4e PUTATIVE
BETA-LACTAMASE
INHIBITOR PROTEIN
(Streptococcus
mutans) 		3 / 3 SER A 163
GLU A 169
GLU A 170
 ACT  A   1 (-2.7A)
None
None
 0.58A 1eqbD-3d4eA:
undetectable		 1eqbD-3d4eA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3d4e PUTATIVE
BETA-LACTAMASE
INHIBITOR PROTEIN
(Streptococcus
mutans) 		3 / 3 SER A 163
GLU A 169
GLU A 170
 ACT  A   1 (-2.7A)
None
None
 0.58A 1eqbB-3d4eA:
undetectable		 1eqbB-3d4eA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3d4e PUTATIVE
BETA-LACTAMASE
INHIBITOR PROTEIN
(Streptococcus
mutans) 		4 / 7 TRP A 175
PHE A 127
VAL A 151
ARG A  52
 None
 1.24A 5uo9A-3d4eA:
undetectable
5uo9B-3d4eA:
undetectable		 5uo9A-3d4eA:
16.06
5uo9B-3d4eA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV9_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3d4e PUTATIVE
BETA-LACTAMASE
INHIBITOR PROTEIN
(Streptococcus
mutans) 		4 / 7 VAL A 151
ARG A  52
TRP A 175
PHE A 127
 None
 1.27A 5vv9A-3d4eA:
undetectable
5vv9B-3d4eA:
undetectable		 5vv9A-3d4eA:
15.51
5vv9B-3d4eA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVA_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3d4e PUTATIVE
BETA-LACTAMASE
INHIBITOR PROTEIN
(Streptococcus
mutans) 		4 / 7 VAL A 151
ARG A  52
TRP A 175
PHE A 127
 None
 1.26A 5vvaA-3d4eA:
undetectable
5vvaB-3d4eA:
undetectable		 5vvaA-3d4eA:
15.51
5vvaB-3d4eA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIF_C_H4BC502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3d4e PUTATIVE
BETA-LACTAMASE
INHIBITOR PROTEIN
(Streptococcus
mutans) 		4 / 7 VAL A 151
ARG A  52
TRP A 175
PHE A 127
 None
 1.18A 6cifC-3d4eA:
undetectable
6cifD-3d4eA:
undetectable		 6cifC-3d4eA:
17.39
6cifD-3d4eA:
17.39