SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3d4j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 3d4j DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Homo
sapiens) 		4 / 5 GLU A 239
ARG A 228
LEU A 255
ASP A 259
 None
 1.09A 1n13B-3d4jA:
undetectable
1n13C-3d4jA:
undetectable		 1n13B-3d4jA:
14.57
1n13C-3d4jA:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 3d4j DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Homo
sapiens) 		4 / 5 LEU A 138
LEU A 148
CYH A  12
THR A  11
 None
 1.42A 2oaxD-3d4jA:
undetectable		 2oaxD-3d4jA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3d4j DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Homo
sapiens) 		4 / 7 LEU A 255
ASP A 259
GLU A 239
ARG A 228
 None
 1.06A 2qqdA-3d4jA:
undetectable
2qqdE-3d4jA:
undetectable		 2qqdA-3d4jA:
8.90
2qqdE-3d4jA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 3d4j DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Homo
sapiens) 		6 / 10 LEU A 395
GLY A  69
GLY A 391
LEU A 390
LEU A 389
ALA A 113
 None
 1.47A 2v3kA-3d4jA:
undetectable		 2v3kA-3d4jA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3d4j DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Homo
sapiens) 		5 / 11 VAL A 319
PHE A 249
PHE A 252
TRP A 192
ILE A 199
 None
 1.45A 3owxA-3d4jA:
undetectable
3owxB-3d4jA:
undetectable		 3owxA-3d4jA:
18.99
3owxB-3d4jA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3d4j DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Homo
sapiens) 		3 / 3 PHE A 263
CYH A 267
HIS A 264
 None
 0.83A 3u9fF-3d4jA:
undetectable		 3u9fF-3d4jA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3d4j DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Homo
sapiens) 		3 / 3 PHE A 263
CYH A 267
HIS A 264
 None
 0.92A 3u9fG-3d4jA:
undetectable		 3u9fG-3d4jA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3d4j DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Homo
sapiens) 		3 / 3 PHE A 263
CYH A 267
HIS A 264
 None
 0.89A 3u9fL-3d4jA:
undetectable		 3u9fL-3d4jA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3d4j DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Homo
sapiens) 		3 / 3 PHE A 263
CYH A 267
HIS A 264
 None
 0.99A 3u9fS-3d4jA:
undetectable		 3u9fS-3d4jA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 3d4j DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Homo
sapiens) 		4 / 6 ALA A 135
ALA A  14
PRO A  15
LEU A 163
 None
 0.90A 4dtzA-3d4jA:
undetectable		 4dtzA-3d4jA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 3d4j DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Homo
sapiens) 		4 / 7 ALA A 135
ALA A  14
PRO A  15
LEU A 163
 None
 0.87A 4du2B-3d4jA:
undetectable		 4du2B-3d4jA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 3d4j DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Homo
sapiens) 		4 / 7 LEU A 315
ALA A 301
VAL A 197
ILE A  21
 None
 0.95A 4eyrA-3d4jA:
undetectable		 4eyrA-3d4jA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3d4j DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Homo
sapiens) 		4 / 7 GLU A  30
GLU A  29
ARG A  27
GLY A 178
 None
 1.02A 4fgzA-3d4jA:
undetectable		 4fgzA-3d4jA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3d4j DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Homo
sapiens) 		4 / 8 GLU A  30
GLU A  29
ARG A  27
GLY A 178
 None
 0.82A 4fgzA-3d4jA:
undetectable
4fgzB-3d4jA:
undetectable		 4fgzA-3d4jA:
19.40
4fgzB-3d4jA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 3d4j DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Homo
sapiens) 		5 / 12 TYR A 131
SER A 114
VAL A 112
ILE A  65
LEU A  83
 None
 1.25A 4k36A-3d4jA:
undetectable		 4k36A-3d4jA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 3d4j DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Homo
sapiens) 		5 / 12 TYR A 142
GLU A 145
VAL A 151
CYH A  82
LEU A  83
 None
 1.48A 4k36A-3d4jA:
undetectable		 4k36A-3d4jA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 3d4j DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Homo
sapiens) 		5 / 12 TYR A 142
GLU A 145
VAL A 151
CYH A  82
LEU A  83
 None
 1.48A 4k36B-3d4jA:
undetectable		 4k36B-3d4jA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME
KP18CYS PEPTIDE)		 3d4j DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Homo
sapiens) 		5 / 12 TYR A 131
SER A 114
VAL A 112
ILE A  65
LEU A  83
 None
 1.25A 4k38A-3d4jA:
undetectable
4k38D-3d4jA:
undetectable		 4k38A-3d4jA:
21.03
4k38D-3d4jA:
3.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 3d4j DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Homo
sapiens) 		5 / 12 TYR A 131
SER A 114
VAL A 112
ILE A  65
LEU A  83
 None
 1.21A 4k39A-3d4jA:
undetectable		 4k39A-3d4jA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3d4j DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Homo
sapiens) 		5 / 11 VAL A 319
PHE A 249
PHE A 252
TRP A 192
ILE A 199
 None
 1.39A 4zvmA-3d4jA:
undetectable
4zvmB-3d4jA:
undetectable		 4zvmA-3d4jA:
18.78
4zvmB-3d4jA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 3d4j DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Homo
sapiens) 		4 / 7 GLU A 205
SER A 203
GLY A 366
ALA A 279
 None
 0.96A 5e26A-3d4jA:
undetectable
5e26B-3d4jA:
undetectable		 5e26A-3d4jA:
20.80
5e26B-3d4jA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3d4j DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Homo
sapiens) 		4 / 5 TYR A 276
VAL A  16
MET A 215
GLY A 214
 None
None
SO4  A 401 ( 4.7A)
None
 1.10A 6hd4A-3d4jA:
undetectable		 6hd4A-3d4jA:
10.43